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Molecular Detection of Hepatitis E Virus in Rivers in the Philippines

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  • Department of Virology II, National Institute of Infectious Diseases, Gakuen 4-7-1, Musashi-Murayama, Tokyo 208-0011, Japan; Department of Clinical Laboratory, Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China; Department of Virology, Tohoku University Graduate School of Medicine, Miyagi 980-8575, Japan; RITM-Tohoku Collaborating Research Center on Emerging and Re-Emerging Infectious Diseases, Filinvest Corporate City, Alabang, Muntinlupa City 1781, the Philippines; Research Institute for Tropical Medicine, Department of Health Compound, FILINVEST Corporate City, Alabang, Muntinlupa City 1781, the Philippines

To understand the hepatitis E virus (HEV)-pollution status in the environment in the Philippines, a total of 12 water samples were collected from rivers in Manila City for detection of HEV RNA. Three of 12 samples were positive for HEV RNA indicating that HEV is circulating in the Philippines. Phylogenetic analysis classified all of the HEV sequences into genotype 3.

Author Notes

* Address correspondence to Koji Ishii, Department of Virology II, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashi-Murayama, Tokyo 208-0011, Japan. E-mail: litc@nih.go.jp

Financial support: This work was supported in part by grants from the Ministry of Health, Labor and Welfare of Japan, and the Japan Initiative for Global Research Network on Infectious Diseases (J-GRID) from the Ministries of Education, Culture, Sports, Science and Technology of Japan.

Authors' addresses: Tian-Cheng Li, Tomoyuki Shiota, Sayaka Yoshizaki, Takaji Wakita, and Koji Ishii, Department of Virology II, National Institute of Infectious Diseases, Tokyo, Japan, E-mails: litc@nih.go.jp, t-shiota@nih.go.jp, yoshizak@nih.go.jp, wakita@nih.go.jp, and kishii@nih.go.jp. Tingting Yang, Department of Clinical Laboratory, Affiliated Hospital of Qingdao University Medical College, Qingdao, China, E-mail: ttyang629@126.com. Hiromu Yoshida, Mariko Saito, Toshifumi Imagawa, and Hitoshi Oshitani, Department of Virology, Tohoku University Graduate School of Medicine, Miyagi, Japan, E-mails: hyoshida@nih.go.jp, saitom@med.tohoku.ac.jp, imagawat@med.tohoku.ac.jp, and oshitanih@med.tohoku.ac.jp. Fidelino F. Malbas and Socorro P. Lupisan, RITM-Tohoku Collaborating Research Center on Emerging and Re-Emerging Infectious Diseases, Filinvest Corporate City, Alabang, Muntinlupa City 1781, the Philippines, E-mails: fidelmalbas@yahoo.com and socorrolupisan@yahoo.com.

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