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1.
Leder K, Torresi J, Libman MD, Cramer JP, Castelli F, Schlagenhauf P, Wilder-Smith A, Wilson ME, Keystone JS, Schwartz E, Barnett ED, von Sonnenburg F, Brownstein JS, Cheng AC, Sotir MJ, Esposito DH, Freedman DO, 2013. GeoSentinel Surveillance Network. GeoSentinel surveillance of illness in returned travelers, 2007–2011. Ann Intern Med 158: 456–468.
-
2.
Centers for Disease Control and Prevention (CDC), 2013. Ongoing dengue epidemic - Angola, June 2013. MMWR Morb Mortal Wkly Rep 62: 504–507.
-
3.
Amarasinghe A, Kuritsk JN, Letson GW, Margolis HS, 2011. Dengue virus infection in Africa. Emerg Infect Dis 17: 1349–1354.
-
4.
Potts JA, Rothman AL, 2008. Clinical and laboratory features that distinguish dengue from other febrile illnesses in endemic populations. Trop Med Int Health 13: 1328–1340.
-
5.
Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, Viramitrachai W, Ratanachu-eke S, Kiatpolpoj S, Innis BL, Rothman AL, Nisalak A, Ennis FA, 1997. Early clinical and laboratory indicators of acute dengue illness. J Infect Dis 176: 313.
-
6.
Kain KC, Harrington MA, Tennyson S, Keystone JS, 1998. Imported malaria: prospective analysis of problems in diagnosis and management. Clin Infect Dis 27: 142–149.
-
7.
WHO, 2009. WHO Guidelines Approved by the Guidelines Review Committee. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition. Geneva: World Health Organization.
-
8.
Taylor SM, Molyneux ME, Simel DL, Meshnick SR, Juliano JJ, 2010. Does this patient have malaria? JAMA 304: 2048–2056.
-
9.
Abro AH, Ustadi AM, Abro HA, Abdou AS, Younis NJ, Akaila SI, 2009. Jaundice with hepatic dysfunction in P. falciparum malaria. J Coll Physicians Surg Pak 19: 363–366.
-
10.
Krüger S, Ewig S, Papassotiriou J, Kunde J, Marre R, von Baum H, Suttor N, Welte T; CAPNETZ Study Group, 2009. Inflammatory parameters predict etiologic patterns but do not allow for individual prediction of etiology in patients with CAP: results from the German competence network CAPNETZ. Respir Res 10: 65.
-
11.
Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J, 2004. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis 39: 206.
-
12.
Hurt N, Smith T, Tanner M, Mwankusye S, Bordmann G, Weiss NA, Teuscher T, 1994. Evaluation of C-reactive protein and haptoglobin as malaria episode markers in an area of high transmission in Africa. Trans R Soc Trop Med Hyg 88: 182–186.
-
13.
Paul R, Sinha PK, Bhattacharya R, Banerjee AK, Raychaudhuri P, Mondal J, 2012. Study of C reactive protein as a prognostic marker in malaria from Eastern India. Adv Biomed Res 1: 41.
-
14.
Gillespie SH, Dow C, Raynes JG, Behrens RH, Chiodini PL, McAdam KP, 1991. Measurement of acute phase proteins for assessing severity of Plasmodium falciparum malaria. J Clin Pathol 44: 228–231.
-
15.
Premaratna R, Bailey MS, Ratnasena BG, de Silva HJ, 2007. Dengue fever mimicking acute appendicitis. Trans R Soc Trop Med Hyg 101: 683–685.
-
16.
Amexo M, Tolhurst R, Barnish G, Bates I, 2004. Malaria misdiagnosis: effects on the poor and vulnerable. Lancet 364: 1896–1898.
-
17.
National Collaborating Centre for Women's and Children's Health (United Kingdom), 2007. Feverish Illness in Children: Assessment and Initial Management in Children Younger Than 5 Years. NICE Clinical Guidelines, No. 47. London, UK: RCOG Press.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1074 | 947 | 345 |
| Full Text Views | 354 | 13 | 1 |
| PDF Downloads | 134 | 14 | 2 |
The Usefulness of Serum C-Reactive Protein and Total Bilirubin Levels for Distinguishing Between Dengue Fever and Malaria in Returned Travelers
Satoshi Kutsuna
Satoshi Kutsuna
National Center for Global Health and Medicine, Disease Control and Prevention Center, Tokyo, Japan
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Kayoko Hayakawa
Kayoko Hayakawa
National Center for Global Health and Medicine, Disease Control and Prevention Center, Tokyo, Japan
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Yasuyuki Kato
Yasuyuki Kato
National Center for Global Health and Medicine, Disease Control and Prevention Center, Tokyo, Japan
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Yoshihiro Fujiya
Yoshihiro Fujiya
National Center for Global Health and Medicine, Disease Control and Prevention Center, Tokyo, Japan
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Momoko Mawatari
Momoko Mawatari
National Center for Global Health and Medicine, Disease Control and Prevention Center, Tokyo, Japan
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Nozomi Takeshita
Nozomi Takeshita
National Center for Global Health and Medicine, Disease Control and Prevention Center, Tokyo, Japan
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Shuzo Kanagawa
Shuzo Kanagawa
National Center for Global Health and Medicine, Disease Control and Prevention Center, Tokyo, Japan
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Norio Ohmagari
Norio Ohmagari
National Center for Global Health and Medicine, Disease Control and Prevention Center, Tokyo, Japan
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The clinical manifestations of dengue fever (DF) and malaria are similar. Specific diagnostic tests are not always available. A retrospective study to compare the laboratory results of malaria and DF was conducted at the National Center for Global Health and Medicine in Japan from January of 2005 to March of 2013. Febrile returned travelers from overseas diagnosed with malaria or DF were included; 86 malaria and 85 DF cases were identified. C-reactive protein (CRP) and total bilirubin (T-bil) had high area under the receiver operating characteristic curves (> 0.9). A cutoff value of CRP > 2.4 mg/dL to predict malaria as opposed to DF had a sensitivity of 91.9% (95% confidence interval [95% CI] = 83.9–96.7%) and specificity of 90.6% (95% CI = 82.3–95.8%). A cutoff value of T-bil > 0.9 mg/dL to predict malaria as opposed to DF had a sensitivity of 73.8% (95% CI = 62.7–83%) and a specificity of 95.1% (95% CI = 88–98.6%). CRP and T-bil are useful to distinguish between DF and malaria in returned travelers.
Author Notes
Financial support: This work was partly supported by funding from the Research on Emerging and Re-Emerging Infectious Diseases by the Ministry of Health, Labour, and Welfare, Japan (H23-shinkou-ippan-006).
Authors' addresses: Satoshi Kutsuna, Kayoko Hayakawa, Yasuyuki Kato, Yoshihiro Fujiya, Momoko Mawatari, Nozomi Takeshita, Shuzo Kanagawa, and Norio Ohmagari, National Center for Global Health and Medicine, Disease Control and Prevention Center, Toyko, Japan, E-mails: sonare.since1192@gmail.com, kayokohayakawa@gmail.com, katodcc@gmail.com, ilvtkfm@yahoo.co.jp, mawatamo@gmail.com, nozomitake@gmail.com, skanagaw@hosp.ncgm.go.jp, and lukenorioom@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
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-
1.
Leder K, Torresi J, Libman MD, Cramer JP, Castelli F, Schlagenhauf P, Wilder-Smith A, Wilson ME, Keystone JS, Schwartz E, Barnett ED, von Sonnenburg F, Brownstein JS, Cheng AC, Sotir MJ, Esposito DH, Freedman DO, 2013. GeoSentinel Surveillance Network. GeoSentinel surveillance of illness in returned travelers, 2007–2011. Ann Intern Med 158: 456–468.
-
2.
Centers for Disease Control and Prevention (CDC), 2013. Ongoing dengue epidemic - Angola, June 2013. MMWR Morb Mortal Wkly Rep 62: 504–507.
-
3.
Amarasinghe A, Kuritsk JN, Letson GW, Margolis HS, 2011. Dengue virus infection in Africa. Emerg Infect Dis 17: 1349–1354.
-
4.
Potts JA, Rothman AL, 2008. Clinical and laboratory features that distinguish dengue from other febrile illnesses in endemic populations. Trop Med Int Health 13: 1328–1340.
-
5.
Kalayanarooj S, Vaughn DW, Nimmannitya S, Green S, Suntayakorn S, Kunentrasai N, Viramitrachai W, Ratanachu-eke S, Kiatpolpoj S, Innis BL, Rothman AL, Nisalak A, Ennis FA, 1997. Early clinical and laboratory indicators of acute dengue illness. J Infect Dis 176: 313.
-
6.
Kain KC, Harrington MA, Tennyson S, Keystone JS, 1998. Imported malaria: prospective analysis of problems in diagnosis and management. Clin Infect Dis 27: 142–149.
-
7.
WHO, 2009. WHO Guidelines Approved by the Guidelines Review Committee. Dengue: Guidelines for Diagnosis, Treatment, Prevention and Control: New Edition. Geneva: World Health Organization.
-
8.
Taylor SM, Molyneux ME, Simel DL, Meshnick SR, Juliano JJ, 2010. Does this patient have malaria? JAMA 304: 2048–2056.
-
9.
Abro AH, Ustadi AM, Abro HA, Abdou AS, Younis NJ, Akaila SI, 2009. Jaundice with hepatic dysfunction in P. falciparum malaria. J Coll Physicians Surg Pak 19: 363–366.
-
10.
Krüger S, Ewig S, Papassotiriou J, Kunde J, Marre R, von Baum H, Suttor N, Welte T; CAPNETZ Study Group, 2009. Inflammatory parameters predict etiologic patterns but do not allow for individual prediction of etiology in patients with CAP: results from the German competence network CAPNETZ. Respir Res 10: 65.
-
11.
Simon L, Gauvin F, Amre DK, Saint-Louis P, Lacroix J, 2004. Serum procalcitonin and C-reactive protein levels as markers of bacterial infection: a systematic review and meta-analysis. Clin Infect Dis 39: 206.
-
12.
Hurt N, Smith T, Tanner M, Mwankusye S, Bordmann G, Weiss NA, Teuscher T, 1994. Evaluation of C-reactive protein and haptoglobin as malaria episode markers in an area of high transmission in Africa. Trans R Soc Trop Med Hyg 88: 182–186.
-
13.
Paul R, Sinha PK, Bhattacharya R, Banerjee AK, Raychaudhuri P, Mondal J, 2012. Study of C reactive protein as a prognostic marker in malaria from Eastern India. Adv Biomed Res 1: 41.
-
14.
Gillespie SH, Dow C, Raynes JG, Behrens RH, Chiodini PL, McAdam KP, 1991. Measurement of acute phase proteins for assessing severity of Plasmodium falciparum malaria. J Clin Pathol 44: 228–231.
-
15.
Premaratna R, Bailey MS, Ratnasena BG, de Silva HJ, 2007. Dengue fever mimicking acute appendicitis. Trans R Soc Trop Med Hyg 101: 683–685.
-
16.
Amexo M, Tolhurst R, Barnish G, Bates I, 2004. Malaria misdiagnosis: effects on the poor and vulnerable. Lancet 364: 1896–1898.
-
17.
National Collaborating Centre for Women's and Children's Health (United Kingdom), 2007. Feverish Illness in Children: Assessment and Initial Management in Children Younger Than 5 Years. NICE Clinical Guidelines, No. 47. London, UK: RCOG Press.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1074 | 947 | 345 |
| Full Text Views | 354 | 13 | 1 |
| PDF Downloads | 134 | 14 | 2 |