• 1.

    Guzman MG, Halstead SB, Artsob H, Buchy P, Farrar J, Gubler DJ, Hunsperger E, Kroeger A, Margolis HS, Martinez E, Nathan MB, Pelegrino JL, Simmons C, Yoksan S, Peeling RW, 2010. Dengue: a continuing global threat. Nat Rev Microbiol 8: S7S16.

    • Search Google Scholar
    • Export Citation
  • 2.

    Kyle JL, Harris E, 2008. Global spread and persistence of dengue. Annu Rev Microbiol 62: 7192.

  • 3.

    Ross TM, 2010. Dengue virus. Clin Lab Med 30: 149160.

  • 4.

    Halstead SB, 2008. Dengue virus-mosquito interactions. Annu Rev Entomol 53: 273291.

  • 5.

    Gubler DJ, 1998. Dengue and dengue hemorrhagic fever. Clin Microbiol Rev 11: 480496.

  • 6.

    Gubler DJ, 2002. Epidemic dengue/dengue hemorrhagic fever as a public health, social and economic problem in the 21st century. Trends Microbiol 10: 100103.

    • Search Google Scholar
    • Export Citation
  • 7.

    Holmes EC, Burch SS, 2000. The causes and consequences of genetic variation in dengue virus. Trends Microbiol 8: 7477.

  • 8.

    Vasilakis N, Weaver SC, 2008. The history and evolution of human dengue emergence. Adv Virus Res 72: 176.

  • 9.

    Chevillon C, Failloux AB, 2003. Questions on viral population biology to complete dengue puzzle. Trends Microbiol 11: 415421.

  • 10.

    Holmes EC, 2003. Patterns of intra- and interhost nonsynonymous variation reveal strong purifying selection in dengue virus. J Virol 77: 1129611298.

    • Search Google Scholar
    • Export Citation
  • 11.

    Parameswaran P, Charlebois P, Tellez Y, Nunez A, Ryan EM, Malboeuf CM, Levin JZ, Lennon NJ, Balmaseda A, Harris E, Henn MR, 2012. Genome-wide patterns of intrahuman dengue virus diversity reveal associations with viral phylogenetic clade and interhost diversity. J Virol 86: 85468558.

    • Search Google Scholar
    • Export Citation
  • 12.

    Anderson JR, Rico-Hesse R, 2006. Aedes aegypti vectorial capacity is determined by the infecting genotype of dengue virus. Am J Trop Med Hyg 75: 886892.

    • Search Google Scholar
    • Export Citation
  • 13.

    Armstrong PM, Rico-Hesse R, 2001. Differential susceptibility of Aedes aegypti to infection by the American and Southeast Asian genotypes of dengue type 2 virus. Vector-Borne Zoonotic Dis 1: 159168.

    • Search Google Scholar
    • Export Citation
  • 14.

    Armstrong PM, Rico-Hesse R, 2003. Efficiency of dengue serotype 2 virus strains to infect and disseminate in Aedes aegypti. Am J Trop Med Hyg 68: 539544.

    • Search Google Scholar
    • Export Citation
  • 15.

    Lambrechts L, Chevillon C, Albright RG, Thaisomboonsuk B, Richardson JH, Jarman RG, Scott TW, 2009. Genetic specificity and potential for local adaptation between dengue viruses and mosquito vectors. BMC Evol Biol 9: 160.

    • Search Google Scholar
    • Export Citation
  • 16.

    Bennett KE, Olson KE, Munoz MD, Fernandez-Salas I, Farfan-Ale JA, Higgs S, Black WC, Beaty BJ, 2002. Variation in vector competence for dengue 2 virus among 24 collections of Aedes aegypti from Mexico and the United States. Am J Trop Med Hyg 67: 8592.

    • Search Google Scholar
    • Export Citation
  • 17.

    Gubler DJ, Nalim S, Tan R, Saipan H, Suliantisaroso J, 1979. Variation in susceptibility to oral infection with dengue viruses among geographic strains of Aedes aegypti. Am J Trop Med Hyg 28: 10451052.

    • Search Google Scholar
    • Export Citation
  • 18.

    Vazeille-Falcoz M, Mousson L, Rodhain F, Chungue E, Failloux AB, 1999. Variation in oral susceptibility to dengue type 2 virus of populations of Aedes aegypti from the islands of Tahiti and Moorea, French Polynesia. Am J Trop Med Hyg 60: 292299.

    • Search Google Scholar
    • Export Citation
  • 19.

    Rosen L, Roseboom LE, Gubler DJ, Lien JC, Chaniotis BN, 1985. Comparative susceptibility of mosquito species and strains to oral and parenteral infection with dengue and Japanese encephalitis viruses. Am J Trop Med Hyg 34: 603615.

    • Search Google Scholar
    • Export Citation
  • 20.

    Hanna JN, Ritchie SA, 2009. Outbreaks of dengue in North Queensland, 1990–2008. Commun Dis Intell 33: 3233.

  • 21.

    Van Den Hurk AF, Craig SB, Tulsiani SM, Jansen CC, 2010. Emerging tropical diseases in Australia. Part 4. Mosquitoborne diseases. Ann Trop Med Parasitol 104: 623640.

    • Search Google Scholar
    • Export Citation
  • 22.

    Queensland-Health, 2012. Dengue in North Queensland. Available at: http://www.health.qld.gov.au/dengue/outbreaks/previous.asp. Accessed July 20, 2013.

    • Search Google Scholar
    • Export Citation
  • 23.

    Beebe NW, Whelan PI, van den Hurk A, Ritchie S, Cooper RD, 2005. Genetic diversity of the dengue vector Aedes aegypti in Australia and implications for future surveillance and mainland incursion monitoring. Commun Dis Intell 29: 299304.

    • Search Google Scholar
    • Export Citation
  • 24.

    Endersby NM, Hoffmann AA, White VL, Lowenstein S, Ritchie S, Johnson PH, Rapley LP, Ryan PA, Nam VS, Yen NT, Kittayapong P, Weeks AR, 2009. Genetic structure of Aedes aegypti in Australia and Vietnam revealed by microsatellite and exon primed intron crossing markers suggests feasibility of local control options. J Med Entomol 46: 10741083.

    • Search Google Scholar
    • Export Citation
  • 25.

    Knox TB, Kay BH, Hall RA, Ryan PA, 2003. Enhanced vector competence of Aedes aegypti (Diptera: Culicidae) from the Torres Strait compared with mainland Australia for dengue 2 and 4 viruses. J Med Entomol 40: 950956.

    • Search Google Scholar
    • Export Citation
  • 26.

    Beebe NW, Cooper RD, Mottram P, Sweeney AW, 2009. Australia's dengue risk driven by human adaptation to climate change. PLoS Negl Trop Dis 3: e429.

    • Search Google Scholar
    • Export Citation
  • 27.

    Moreira LA, Saig E, Turley AP, Ribeiro JM, O'Neill SL, McGraw EA, 2009. Human probing behavior of Aedes aegypti when infected with a life-shortening strain of Wolbachia. PLoS Negl Trop Dis 3: e568.

    • Search Google Scholar
    • Export Citation
  • 28.

    Frentiu FD, Robinson J, Young PR, McGraw EA, O'Neill SL, 2010. Wolbachia-mediated resistance to dengue virus infection and death at the cellular level. PLoS One 5: e13398.

    • Search Google Scholar
    • Export Citation
  • 29.

    Warrilow D, Northill JA, Pyke A, Smith GA, 2002. Single rapid TaqMan fluorogenic probe based PCR assay that detects all four dengue serotypes. J Med Virol 66: 524528.

    • Search Google Scholar
    • Export Citation
  • 30.

    Kien DTH, Tuan TV, Hanh TNT, Chau TNB, Huy HLA, Wills BA, Simmons CP, 2011. Validation of an internally controlled one-step real-time multiplex RT-PCR assay for the detection and quantitation of dengue virus RNA in plasma. J Med Virol 177: 168173.

    • Search Google Scholar
    • Export Citation
  • 31.

    Lambrechts L, Scott TW, 2009. Mode of transmission and the evolution of arbovirus virulence in mosquito vectors. Proc Biol Sci 276: 13691378.

    • Search Google Scholar
    • Export Citation
  • 32.

    Xi Z, Ramirez JL, Dimopoulos G, 2008. The Aedes aegypti toll pathway controls dengue virus infection. PLoS Pathog 4: e1000098.

  • 33.

    Ye YH, Chenoweth SF, McGraw EA, 2009. Effective but costly, evolved mechanisms of defense against a virulent opportunistic pathogen in Drosophila melanogaster. PLoS Pathog 5: e1000385.

    • Search Google Scholar
    • Export Citation
  • 34.

    Yoon IK, Getis A, Aldstadt J, Rothman AL, Tannitisupawong D, Koenraadt CJ, Fansiri T, Jones JW, Morrison AC, Jarman RG, Nisalak A, Mammen MP Jr, Thammapalo S, Srikiatkhachorn A, Green S, Libraty DH, Gibbons RV, Endy T, Pimgate C, Scott TW, 2012. Fine scale spatiotemporal clustering of dengue virus transmission in children and Aedes aegypti in rural Thai villages. PLoS Neglect Trop Dis 6: e1730.

    • Search Google Scholar
    • Export Citation
  • 35.

    Neff JM, Morris L, Gonzalez R, Coleman PH, Lyss SB, Negron H, 1967. Dengue fever in a Puerto Rican community. Am J Epidemiol 86: 162184.

  • 36.

    Halstead SB, Nimmannitta S, Margiotta MR, 1969. Dengue and Chikungunya virus infection in man in Thailand, 1962–1964: II. Observations on disease in outpatients. Am J Trop Med Hyg 18: 972983.

    • Search Google Scholar
    • Export Citation
  • 37.

    Failloux AB, Darius H, Pasteur N, 1995. Genetic differentiation of Aedes aegypti, the vector of dengue virus in French Polynesia. J Am Mosq Control Assoc 11: 457462.

    • Search Google Scholar
    • Export Citation
  • 38.

    Huber K, Loan LL, Chantha N, Failloux AB, 2004. Human transportation influences Aedes aegypti gene flow in Southeast Asia. Acta Trop 90: 2329.

  • 39.

    Paupy C, Vazeille-Falcoz M, Mousson L, Rodhain F, Failloux AB, 2000. Aedes aegypti in Tahiti and Moorea (French Polynesia): isoenzyme differentiation in the mosquito population according to human population density. Am J Trop Med Hyg 62: 217224.

    • Search Google Scholar
    • Export Citation
  • 40.

    Bosio CF, Beaty BJ, Black WC 4th, 1998. Quantitative genetics of vector competence for dengue-2 virus in Aedes aegypti. Am J Trop Med Hyg 59: 965970.

    • Search Google Scholar
    • Export Citation
  • 41.

    Forrester NL, Guerbois M, Seymour RL, Spratt H, Weaver SC, 2012. Vector-borne transmission imposes a severe bottleneck on an RNA virus population. PLoS Pathog 8: e1002897.

    • Search Google Scholar
    • Export Citation

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 

Comparative Susceptibility of Mosquito Populations in North Queensland, Australia to Oral Infection with Dengue Virus

View More View Less
  • School of Biological Sciences, Monash University, Clayton, Victoria, Australia; Institute for Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia; Public Health Virology, Forensic and Scientific Services, Department of Health, Coopers Plains, Queensland, Australia; School of Biological Sciences, University of Queensland, St. Lucia, Queensland, Australia

Dengue is the most prevalent arthropod-borne virus, with at least 40% of the world's population at risk of infection each year. In Australia, dengue is not endemic, but viremic travelers trigger outbreaks involving hundreds of cases. We compared the susceptibility of Aedes aegypti mosquitoes from two geographically isolated populations to two strains of dengue virus serotype 2. We found, interestingly, that mosquitoes from a city with no history of dengue were more susceptible to virus than mosquitoes from an outbreak-prone region, particularly with respect to one dengue strain. These findings suggest recent evolution of population-based differences in vector competence or different historical origins. Future genomic comparisons of these populations could reveal the genetic basis of vector competence and the relative role of selection and stochastic processes in shaping their differences. Lastly, we show the novel finding of a correlation between midgut dengue titer and titer in tissues colonized after dissemination.

Author Notes

* Address correspondence to Elizabeth A. McGraw, School of Biological Sciences, Monash University, Building 53, Clayton, VIC, Australia 3800. E-mail: beth.mcgraw@monash.edu† These authors contributed equally.

Financial support: This work was supported by grants from the National Health and Medical Research Council Australia.

Authors' addresses: Yixin H. Ye, Tat Siong Ng, Thomas Walker, and Elizabeth A. McGraw, School of Biological Sciences, Monash University, Clayton, VIC, Australia, E-mails: henry.ye@monash.edu, tatsiong.ng@uqconnect.edu.au, thomas_walker79@hotmail.com, and beth.mcgraw@monash.edu. Francesca D. Frentiu, Institute for Health and Biomedical Innovation, Queensland University of Technology, Brisbane, QLD, Australia, E-mail: francesca.frentiu@qut.edu.au. Andrew F. van den Hurk, Virology, Queensland Health Forensic and Scientific Services, Coopers Plains, QLD, Australia, E-mail: andrew_hurk@health.qld.gov.au. Scott L. O'Neill, Faculty of Science, School of Biological Sciences, Monash University, Clayton, VIC, Australia, and Institute of Molecular Biosciences, University of Queensland, St. Lucia, QLD, Australia, E-mail: scott.oneill@monash.edu. Nigel W. Beebe, School of Biological Sciences, University of Queensland, St. Lucia, QLD, Australia, E-mail: n.beebe@uq.edu.au.

Save