Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
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-
1.
Cohen J, 2006. HIV/AIDS: Latin America and the Caribbean, South America. Science 313: 484.
-
2.
Nacher M, Vantilcke V, Parriault MC, Van Melle A, Hanf M, Labadie G, Romeo M, Adriouch L, Carles G, Couppie P, 2010. What is driving the HIV epidemic in French Guiana? Int J STD AIDS 21: 359–361.
-
3.
Brazil MoHo, 2012. Boletim Epidemiológico Aids e DST, 2012 Report.
-
5.
Colombo AL, Tobon A, Restrepo A, Queiroz-Telles F, Nucci M, 2011. Epidemiology of endemic systemic fungal infections in Latin America. Med Mycol 49: 785–798.
-
6.
Krug ES, Glenn HR, 1948. Comparative studies in tuberculosis and histoplasmosis among 2000 students entering Pennsylvania State College, September, 1947. J Lancet 68: 206–208.
-
7.
Couppie P, Aznar C, Carme B, Nacher M, 2006. American histoplasmosis in developing countries with a special focus on patients with HIV: diagnosis, treatment, and prognosis. Curr Opin Infect Dis 19: 443–449.
-
8.
Huber F, Nacher M, Aznar C, Pierre-Demar M, El Guedj M, Vaz T, Vantilcke V, Mahamat A, Magnien C, Chauvet E, Carme B, Couppie P, 2008. AIDS-related Histoplasma capsulatum var. capsulatum infection: 25 years experience of French Guiana. AIDS 22: 1047–1053.
-
9.
Couppie P, Sobesky M, Aznar C, Bichat S, Clyti E, Bissuel F, El Guedj M, Alvarez F, Demar M, Louvel D, Pradinaud R, Carme B, 2004. Histoplasmosis and acquired immunodeficiency syndrome: a study of prognostic factors. Clin Infect Dis 38: 134–138.
-
10.
Nacher M, Adenis A, Adriouch L, Dufour J, Papot E, Hanf M, Vantilcke V, Calvez M, Aznar C, Carme B, Couppie P, 2011. What is AIDS in the Amazon and the Guianas? Establishing the burden of disseminated histoplasmosis. Am J Trop Med Hyg 84: 239–240.
-
11.
Hay RJ, White HS, Fields PE, Quamina DB, Dan M, Jones TR, 1981. Histoplasmosis in the eastern Caribbean: a preliminary survey of the incidence of the infection. J Trop Med Hyg 84: 9–12.
-
12.
Ajello L, 1971. The medical mycological iceberg. HSMHA Health Rep 86: 437–448.
-
13.
Initiative DND, 2012. Alternative Formulations of Amphotericin B.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 22 | 22 | 3 |
| Full Text Views | 335 | 97 | 0 |
| PDF Downloads | 92 | 23 | 0 |
How Many Have Died from Undiagnosed Human Immunodeficiency Virus–Associated Histoplasmosis, A Treatable Disease? Time to Act
Mathieu Nacher
Mathieu Nacher
Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC-EC CIE 802, Cayenne General Hospital, Cayenne, French Guiana; Coordination Regionale de la Lutte Contre le VIH de Guyane, Laboratoire Hospitalo-Universitaire de Parasitologie Mycologie, Unité des Maladies Infectieuses et Tropicale, et Service de Dermatologie Vénéréologie, Centre Hospitalier de Cayenne, Cayenne, French Guiana; Equipe EPaT EA3593 Epidemiologie des Parasitoses et Mycoses Tropicales, Université Antilles Guyane, Cayenne, French Guiana
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Antoine Adenis
Antoine Adenis
Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC-EC CIE 802, Cayenne General Hospital, Cayenne, French Guiana; Coordination Regionale de la Lutte Contre le VIH de Guyane, Laboratoire Hospitalo-Universitaire de Parasitologie Mycologie, Unité des Maladies Infectieuses et Tropicale, et Service de Dermatologie Vénéréologie, Centre Hospitalier de Cayenne, Cayenne, French Guiana; Equipe EPaT EA3593 Epidemiologie des Parasitoses et Mycoses Tropicales, Université Antilles Guyane, Cayenne, French Guiana
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Christine Aznar
Christine Aznar
Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC-EC CIE 802, Cayenne General Hospital, Cayenne, French Guiana; Coordination Regionale de la Lutte Contre le VIH de Guyane, Laboratoire Hospitalo-Universitaire de Parasitologie Mycologie, Unité des Maladies Infectieuses et Tropicale, et Service de Dermatologie Vénéréologie, Centre Hospitalier de Cayenne, Cayenne, French Guiana; Equipe EPaT EA3593 Epidemiologie des Parasitoses et Mycoses Tropicales, Université Antilles Guyane, Cayenne, French Guiana
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Denis Blanchet
Denis Blanchet
Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC-EC CIE 802, Cayenne General Hospital, Cayenne, French Guiana; Coordination Regionale de la Lutte Contre le VIH de Guyane, Laboratoire Hospitalo-Universitaire de Parasitologie Mycologie, Unité des Maladies Infectieuses et Tropicale, et Service de Dermatologie Vénéréologie, Centre Hospitalier de Cayenne, Cayenne, French Guiana; Equipe EPaT EA3593 Epidemiologie des Parasitoses et Mycoses Tropicales, Université Antilles Guyane, Cayenne, French Guiana
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Vincent Vantilcke
Vincent Vantilcke
Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC-EC CIE 802, Cayenne General Hospital, Cayenne, French Guiana; Coordination Regionale de la Lutte Contre le VIH de Guyane, Laboratoire Hospitalo-Universitaire de Parasitologie Mycologie, Unité des Maladies Infectieuses et Tropicale, et Service de Dermatologie Vénéréologie, Centre Hospitalier de Cayenne, Cayenne, French Guiana; Equipe EPaT EA3593 Epidemiologie des Parasitoses et Mycoses Tropicales, Université Antilles Guyane, Cayenne, French Guiana
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Magalie Demar
Magalie Demar
Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC-EC CIE 802, Cayenne General Hospital, Cayenne, French Guiana; Coordination Regionale de la Lutte Contre le VIH de Guyane, Laboratoire Hospitalo-Universitaire de Parasitologie Mycologie, Unité des Maladies Infectieuses et Tropicale, et Service de Dermatologie Vénéréologie, Centre Hospitalier de Cayenne, Cayenne, French Guiana; Equipe EPaT EA3593 Epidemiologie des Parasitoses et Mycoses Tropicales, Université Antilles Guyane, Cayenne, French Guiana
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Bernard Carme
Bernard Carme
Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC-EC CIE 802, Cayenne General Hospital, Cayenne, French Guiana; Coordination Regionale de la Lutte Contre le VIH de Guyane, Laboratoire Hospitalo-Universitaire de Parasitologie Mycologie, Unité des Maladies Infectieuses et Tropicale, et Service de Dermatologie Vénéréologie, Centre Hospitalier de Cayenne, Cayenne, French Guiana; Equipe EPaT EA3593 Epidemiologie des Parasitoses et Mycoses Tropicales, Université Antilles Guyane, Cayenne, French Guiana
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Pierre Couppié
Pierre Couppié
Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC-EC CIE 802, Cayenne General Hospital, Cayenne, French Guiana; Coordination Regionale de la Lutte Contre le VIH de Guyane, Laboratoire Hospitalo-Universitaire de Parasitologie Mycologie, Unité des Maladies Infectieuses et Tropicale, et Service de Dermatologie Vénéréologie, Centre Hospitalier de Cayenne, Cayenne, French Guiana; Equipe EPaT EA3593 Epidemiologie des Parasitoses et Mycoses Tropicales, Université Antilles Guyane, Cayenne, French Guiana
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Human immunodeficiency virus (HIV)–associated disseminated Histoplasma capsulatum capsulatum infection often mimics tuberculosis. This disease is well know in the United States but is dramatically underdiagnosed in Central and South America. In the Amazon region, given the available incidence data and the regional HIV prevalence, it is expected that, every year, 1,500 cases of histoplasmosis affect HIV patients in that region alone. Given the mortality in undiagnosed patients, at least 600 patients would be expected to die from an undiagnosed but treatable disease. The lack of a simple diagnostic tool and the lack of awareness by clinicians spiral in a vicious cycle and made a major problem invisible for 30 years. The HIV/acquired immunodeficiency syndrome community should tackle this problem now to prevent numerous avoidable deaths from HIV-associated histoplasmosis in the region and elsewhere.
Author Notes
Authors' addresses: Mathieu Nacher, Centre Hospitalier de Cayenne, Rue des Flamboyants, Cayenne 97300, French Guiana, E-mail: mathieu.nacher@ch-cayenne.fr. Antoine Adenis, Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane, INSERM DGOS CIE 802, Cayenne General Hospital, Avenue des Flamboyants, Cayenne 97306, French Guiana, E-mail: antoine.adenis@ch-cayenne.fr. Christine Aznar, Service Hospitalo Universitaire de Parasitologie Mycologie, Centre Hospitalier de Cayenne, Cayenne, French Guiana, E-mail: christine.aznar@ch-cayenne.fr. Denis Blanchet, Laboratoire Hospitalo Universitaire de Parasitologie Mycologie, Centre Hospitalier de Cayenne, Cayenne, French Guiana, E-mail: denis.blanchet@ch-cayenne.fr. Vincent Vantilcke, Service de Médecine, Centre Hospitalier de l'Ouest Guyanais, Saint Laurent du Maroni, French Guiana, E-mail: v.vantilcke@ch-ouestguyane.fr. Magalie Demar, Department of Infectious and Tropical Disease, Centre Hospitalier Andrée Rosemon, Cayenne, French Guiana, E-mail: magalie.demar@ch-cayenne.fr. Bernard Carme, Centre d'Investigation Clinique Épidémiologie Clinique Antilles Guyane, CIE INSERM 802, Pole de Guyane, Centre Hospitalier de Cayenne, Cayenne, French Guiana, E-mail: bernard.carme@ch-cayenne.fr. Pierre Couppié, Equipe EA 3593, Epidemiologie des Parasitoses et Mycoses Tropicales, Universite des Antilles et de la Guyane, Cayenne, French Guiana, E-mail: couppie.pierre@voila.fr.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Cohen J, 2006. HIV/AIDS: Latin America and the Caribbean, South America. Science 313: 484.
-
2.
Nacher M, Vantilcke V, Parriault MC, Van Melle A, Hanf M, Labadie G, Romeo M, Adriouch L, Carles G, Couppie P, 2010. What is driving the HIV epidemic in French Guiana? Int J STD AIDS 21: 359–361.
-
3.
Brazil MoHo, 2012. Boletim Epidemiológico Aids e DST, 2012 Report.
-
5.
Colombo AL, Tobon A, Restrepo A, Queiroz-Telles F, Nucci M, 2011. Epidemiology of endemic systemic fungal infections in Latin America. Med Mycol 49: 785–798.
-
6.
Krug ES, Glenn HR, 1948. Comparative studies in tuberculosis and histoplasmosis among 2000 students entering Pennsylvania State College, September, 1947. J Lancet 68: 206–208.
-
7.
Couppie P, Aznar C, Carme B, Nacher M, 2006. American histoplasmosis in developing countries with a special focus on patients with HIV: diagnosis, treatment, and prognosis. Curr Opin Infect Dis 19: 443–449.
-
8.
Huber F, Nacher M, Aznar C, Pierre-Demar M, El Guedj M, Vaz T, Vantilcke V, Mahamat A, Magnien C, Chauvet E, Carme B, Couppie P, 2008. AIDS-related Histoplasma capsulatum var. capsulatum infection: 25 years experience of French Guiana. AIDS 22: 1047–1053.
-
9.
Couppie P, Sobesky M, Aznar C, Bichat S, Clyti E, Bissuel F, El Guedj M, Alvarez F, Demar M, Louvel D, Pradinaud R, Carme B, 2004. Histoplasmosis and acquired immunodeficiency syndrome: a study of prognostic factors. Clin Infect Dis 38: 134–138.
-
10.
Nacher M, Adenis A, Adriouch L, Dufour J, Papot E, Hanf M, Vantilcke V, Calvez M, Aznar C, Carme B, Couppie P, 2011. What is AIDS in the Amazon and the Guianas? Establishing the burden of disseminated histoplasmosis. Am J Trop Med Hyg 84: 239–240.
-
11.
Hay RJ, White HS, Fields PE, Quamina DB, Dan M, Jones TR, 1981. Histoplasmosis in the eastern Caribbean: a preliminary survey of the incidence of the infection. J Trop Med Hyg 84: 9–12.
-
12.
Ajello L, 1971. The medical mycological iceberg. HSMHA Health Rep 86: 437–448.
-
13.
Initiative DND, 2012. Alternative Formulations of Amphotericin B.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 22 | 22 | 3 |
| Full Text Views | 335 | 97 | 0 |
| PDF Downloads | 92 | 23 | 0 |