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Chemokine Profile in the Sera and Urine of Patients with Schistosomal Glomerulopathy

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  • Department of Infectology and Tropical Medicine, Federal University of Minas Gerais, Brazil; Department of Imunology, Federal University of Minas Gerais, Brazil; Department of Epidemiology, Federal University of Minas Gerais, Brazil; Department of Nephrology, Federal University of Minas Gerais, Brazil

We investigated the serum and urine chemokine levels of patients with schistosomal mansoni glomerulonephritis. This cross-sectional study was conducted in the Southeast of Brazil. Overall, 160 subjects were enrolled and divided into five groups: 1) hepatosplenic schistosomiasis with renal disease (N = 12); 2) hepatosplenic schistosomiasis without renal disease (N = 68); 3) hepatointestinal schistosomiasis (N = 27); 4) glomerulopathy caused by other diseases (N = 22); and 5) healthy controls (N = 31). The patients with microalbuminuria > 30 mg in 24 hours were considered to have renal disease. The sera and urine chemokines CCL2, CCL3, CCL5, CCL11, and CXCL8 were measured using an enzyme-linked immunosorbent assay test. A similar profile was observed between the patients with schistosomal glomerulopathy and the patients with glomerulopathy caused by other diseases, with the exception of serum CCL2 ≤ 634.3 pg/mL. In cases with sera CCL2 > 634.3 pg/mL, the diagnosis of schistosomal glomerulopathy should be considered.

Author Notes

* Address correspondence to José Roberto Lambertucci, Department of Infectology and Tropical Medicine, Federal University of Minas Gerais, Avenida Alfredo Balena, 190, Belo Horizonte, Minas Gerais, Brazil 30130-100. E-mail: lamber@uai.com.br

Financial support: This work has been partially supported by the FAPEMIG and CNPq/Brazil.

Authors' addresses: Alba Otoni, Izabela Voieta, and Vinícius Lins Costa Melo, Universidade Federal de Minas Gerais - Medicina Tropical, Belo Horizonte, Minas Gerais, Brazil, E-mails: albaotoni01@yahoo.com.br, voieta@uol.com.br, and vilinscm@gmail.com. Antônio Lúcio Teixeira, Federal University de Minas Gerais - Internal Medicine and Laboratory of Immunopharmacology, Belo Horizonte, Minas Gerais, E-mails: altexr@gmail.com or altexjr@hotmail.com. Carlos Maurício Antunes, Santa Casa de Misericórdia de Belo Horizonte - Epidemiologia, Belo Horizonte, Minas Gerais, Brazil, E-mail: antunesc@santacasabh.org.br. Sandra Costa Drummond, Secreatria Estadual de Saùde - Helmintologia, Belo Horizonte, Minas Gerais, Brazil, E-mail: sandracdrummond@yahoo.com.br. Valério Ladeira Rodrigues, Universidade Federal de Minas Gerais - Nephrology, Belo Horizonte, Minas Gerais, Brazil, E-mail: varodrigues@uai.com.br. José Roberto Lambertucci, Department of Infectology and Tropical Medicine, Federal University of Minas Gerais, Belo Horizonte, Minas Gerais, Brazil, E-mail: lamber@uai.com.br.

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