World Health Organization, 2011. Fact Sheet Malaria. Available at: http://www.who.int/mediacentre/factsheets/fs094/en/. Accessed October 31, 2011.
Sachs J, Malaney P, 2002. The economic and social burden of malaria. Nature 415: 680–685.
World Health Organization, 2010. Guidelines for the Treatment of Malaria. Geneva: WHO.
White NJ, Olliaro PL, 1996. Strategies for the prevention of antimalarial drug resistance: rationale for combination chemotherapy for malaria. Parasitol Today 12: 399–401.
Bloland PB, 2001. Drug Resistance in Malaria. Geneva: World Health Organization.
Kachur SP, Khatib RA, Kaizer E, Fox SS, Abdulla SM, Bloland PB, 2004. Adherence to antimalarial combination therapy with sulfadoxine-pyrimethamine and artesunate in rural Tanzania. Am J Trop Med Hyg 71: 715–722.
Fogg C, Bajunirwe F, Piola P, Biraro S, Checchi F, Kiguli J, Namiiro P, Musabe J, Kyomugisha A, Guthmann JP, 2004. Adherence to a six-dose regimen of artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Uganda. Am J Trop Med Hyg 71: 525–530.
Kabanywanyi AM, Lengeler C, Kasim P, King'eng'ena S, Schlienger R, Mulure N, Genton B, 2010. Adherence to and acceptability of artemether-lumefantrine as first-line anti-malarial treatment: evidence from a rural community in Tanzania. Malar J 9: 48.
Beer N, Ali AS, Rotllant G, Abass AK, Omari RS, Al-Mafazy AW, Bjorkman A, Kallander K, 2009. Adherence to artesunate-amodiaquine combination therapy for uncomplicated malaria in children in Zanzibar, Tanzania. Trop Med Int Health 14: 766–774.
Yeung S, White NJ, 2005. How do patients use antimalarial drugs? A review of the evidence. Trop Med Int Health 10: 121–138.
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D, 2009. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339: b2700.
Higgins JPT, Green S, 2011. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. Available at: www.cochrane-handbook.org. Accessed March 1, 2013.
Higgins JPT, Green S, 2008. Cochrane Handbook for Systematic Reviews of Interventions. Chichester: John Wiley & Son Ltd.
Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ, 1996. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17: 1–12.
Higgins JPT, Thompson SG, 2002. Quantifying heterogeneity in a meta-analysis. Stat Med 11: 1539–1558.
Deeks JJ, Higgins JPT, Altman DG (ed), 2008. Chapter 9: analysing data and undertaking meta-analyses. In: Higgins JPT, Green S (eds). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.0.1 [updated September 2008]. The Cochrane Collaboration. Available at: www.cochrane-handbook.org.
Qingjun L, Jihui D, Laiyi T, Xiangjun Z, Jun L, Hay A, Shires S, Navaratnam V, 1998. The effect of drug packaging on patients' compliance with treatment for Plasmodium vivax malaria in China. Bull World Health Organ 76 (Suppl 1): 21–27.
Denis MB, 1998. Improving compliance with quinine + tetracycline for treatment of malaria: evaluation of health education interventions in Cambodian villages. Bull World Health Organ 76 (Suppl 1): 43–49.
Fungladda W, Honrado ER, Thimasarn K, Kitayaporn D, Karbwang J, Kamolratanakul P, Masngammueng R, 1998. Compliance with artesunate and quinine + tetracycline treatment of uncomplicated falciparum malaria in Thailand. Bull World Health Organ 76 (Suppl 1): 59–66.
Ansah EK, Gyapong JO, Agyepong IA, Evans DB, 2001. Improving adherence to malaria treatment for children: the use of pre-packed chloroquine tablets vs. chloroquine syrup. Trop Med Int Health 6: 496–504.
Yeboah-Antwi K, Gyapong JO, Asare IK, Barnish G, Evans DB, Adjei S, 2001. Impact of prepackaging antimalarial drugs on cost to patients and compliance with treatment. Bull World Health Organ 79: 394–399.
Okonkwo PO, Akpala CO, Okafor HU, Mbah AU, Nwaiwu O, 2001. Compliance to correct dose of chloroquine in uncomplicated malaria correlates with improvement in the condition of rural Nigerian children. Trans R Soc Trop Med Hyg 95: 320–324.
Winch PJ, Bagayoko A, Diawara A, Kane M, Thiero F, Gilroy K, Daou Z, Berthe Z, Swedberg E, 2003. Increases in correct administration of chloroquine in the home and referral of sick children to health facilities through a community-based intervention in Bougouni District, Mali. Trans R Soc Trop Med Hyg 97: 481–490.
Agyepong IA, Ansah E, Gyapong M, Adjei S, Barnish G, Evans D, 2002. Strategies to improve adherence to recommended chloroquine treatment regimes: a quasi-experiment in the context of integrated primary health care delivery in Ghana. Soc Sci Med 55: 2215–2226.
Afenyadu GY, Agyepong IA, Barnish G, Adjei S, 2005. Improving access to early treatment of malaria: a trial with primary school teachers as care providers. Trop Med Int Health 10: 1065–1072.
Achan J, Tibenderana JK, Kyabayinze D, Wabwire Mangen F, Kamya MR, Dorsey G, D'Alessandro U, Rosenthal PJ, Talisuna AO, 2009. Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomized trial. BMJ 339: b2763.
Lauwo JA, Hombhanje FW, Tulo SP, Maibani G, Bjorge S, 2006. Impact of pre-packaging antimalarial drugs and counseling on compliance with malaria treatment at Port Moresby General Hospital Adult Outpatient Department. P N G Med J 49: 14–21.
Rahman MM, Dondorp AM, Day NPJ, Lindegardh N, Imwong M, Faiz MA, Bangali AM, Kamal AT, Karim J, Kaewkungwal J, Singhasivanon P, 2008. Adherence and efficacy of supervised versus non-supervised treatment with artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh: a randomized controlled trial. Trans R Soc Trop Med Hyg 102: 861–867.
Faucher JF, Aubouy A, Adeothy A, Cottrell G, Doritchamou J, Gourmel B, Houze P, Kossou H, Amedome H, Massougbodji A, Cot M, Deloron P, 2009. Comparison of sulfadoxine-pyrimethamine, unsupervised artemether-lumefantrine, and unsupervised artesunate-amodiaquine fixed-dose formulation for uncomplicated Plasmodium falciparum malaria in Benin: a randomized effectiveness noninferiority trial. J Infect Dis 200: 57–65.
Takeuchi R, Lawpoolsri S, Imwong M, Kobayashi J, Kaewkungwal J, Pukrittayakamee S, Puangsa-Art S, Thanyavanich N, Maneeboonyang W, Day NP, Singhasivanon P, 2010. Directly-observed therapy (DOT) for the radical 14-day primaquine treatment of Plasmodium vivax malaria on the Thai-Myanmar border. Malar J 9: 308.
Dunyo S, Sirugo G, Sesay S, Bisseye C, Njie F, Adiamoh M, Nwakanma D, Diatta M, Janha R, Sisay Joof F, Temple B, Snell P, Conway D, Walton R, Cheung YB, Milligan P, 2011. Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia. PLoS ONE 6: e17371.
Kangwana BP, Kedenge SV, Noor AM, Alegana VA, Nyandigisi AJ, Pandit J, Fegan GW, Todd JE, Brooker S, Snow RW, Goodman CA, 2011. The impact of retail-sector delivery of artemether-lumefantrine on malaria treatment of children under five in Kenya: a cluster randomized controlled trial. PLoS Med 8: e1000437.
Krueger KP, Berger BA, Felkey B, 2005. Medication adherence and persistence: a comprehensive review. Adv Ther 22: 313–356.
Berben L, Bogert L, Leventhal ME, Fridlund B, Jaarsma T, Norekval TM, Smith K, Stromberg A, Thompson DR, De Geest S, 2011. Which interventions are used by health care professionals to enhance medication adherence in cardiovascular patients? A survey of current clinical practice. Eur J Cardiovasc Nurs 10: 14–21.
Wu YP, Roberts MC, 2008. A meta-analysis of interventions to increase adherence to medication regimens for pediatric otitis media and streptococcal pharyngitis. J Pediatr Psychol 33: 789–796.
Fjeldsoe BS, Marshall AL, Miller YD, 2009. Behavior change interventions delivered by mobile telephone short-message service. Am J Prev Med 36: 165–173.
Meankaew P, Kaewkungwal J, Khamsiriwatchara A, Khunthong P, Singhasivanon P, Satimai W, 2010. Application of mobile-technology for disease and treatment monitoring of malaria in the “Better Border Healthcare Programme”. Malar J 10: 69.
Bowry AD, Shrank WH, Lee JL, Stedman M, Choudhry NK, 2011. A systematic review of adherence to cardiovascular medications in resource-limited settings. J Gen Intern Med 26: 1479–1491.
Sandercock P, 2011. The authors say: ‘The data are not so robust because of heterogeneity’ - so, how should I deal with this systematic review? Meta-analysis and the clinician. Cerebrovasc Dis 31: 615–620.
Twagirumukiza M, Kayumba PC, Kips JG, Vrijens B, Stichele RV, Vervaet C, Remon JP, Van Bortel ML, 2010. Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants. Malar J 9: 206.
Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG, 2010. CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomized trials. J Clin Epidemiol 63: e1–e37.
Velligan D, Sajatovic M, Valenstein M, Riley WT, Safren S, Lewis-Fernandez R, Weiden P, Ogedegbe G, Jamison J, 2010. Methodological challenges in psychiatric treatment adherence research. Clin Schizophr Relat Psychoses 4: 74–91.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 472 | 267 | 27 |
Full Text Views | 419 | 22 | 1 |
PDF Downloads | 166 | 23 | 1 |
Non-adherence as a major contributor to poor treatment outcomes. This study aimed to explore the effectiveness of existing interventions promoting adherence to antimalarial drugs by systematic review. The following databases were used to identify potential articles: MEDLINE, EMBASE, the Cochrane CENTRAL, and CINAHL (through March 2013). From 1,813 potential papers identified, 16 studies met the selection criteria comprising 9,247 patients. Interventions were classified as packaging aids, visual media, combined visual media and verbal information, community education, medication supervision, and convenient regimen. These interventions were shown to increase adherence to antimalarial drugs (median relative risk = 1.4, interquartile range 1.2–2.0). Although a most effective intervention did not emerge, community education and visual media/verbal information combinations may well have most potential to improve adherence to antimalarial medication. These interventions should be implemented in combination to optimize their beneficial effects. The current understanding on improved adherence would facilitate to contain outbreaks of malaria cost effectively.
Authors' addresses: Anjana Fuangchan and Teerapon Dhippayom, Pharmaceutical Care Research Unit, Faculty of Pharmaceutical Sciences, Naresuan University, Muang, Phitsanulok, Thailand, E-mails: anjana.fuangchan@gmail.com and teerapond@hotmail.com. Chuenjid Kongkaew, Faculty of Pharmaceutical Sciences, Naresuan University, Muang, Phitsanulok, Thailand, E-mails: chuenjidk@nu.ac.th or chuenjid@googlemail.com.
World Health Organization, 2011. Fact Sheet Malaria. Available at: http://www.who.int/mediacentre/factsheets/fs094/en/. Accessed October 31, 2011.
Sachs J, Malaney P, 2002. The economic and social burden of malaria. Nature 415: 680–685.
World Health Organization, 2010. Guidelines for the Treatment of Malaria. Geneva: WHO.
White NJ, Olliaro PL, 1996. Strategies for the prevention of antimalarial drug resistance: rationale for combination chemotherapy for malaria. Parasitol Today 12: 399–401.
Bloland PB, 2001. Drug Resistance in Malaria. Geneva: World Health Organization.
Kachur SP, Khatib RA, Kaizer E, Fox SS, Abdulla SM, Bloland PB, 2004. Adherence to antimalarial combination therapy with sulfadoxine-pyrimethamine and artesunate in rural Tanzania. Am J Trop Med Hyg 71: 715–722.
Fogg C, Bajunirwe F, Piola P, Biraro S, Checchi F, Kiguli J, Namiiro P, Musabe J, Kyomugisha A, Guthmann JP, 2004. Adherence to a six-dose regimen of artemether-lumefantrine for treatment of uncomplicated Plasmodium falciparum malaria in Uganda. Am J Trop Med Hyg 71: 525–530.
Kabanywanyi AM, Lengeler C, Kasim P, King'eng'ena S, Schlienger R, Mulure N, Genton B, 2010. Adherence to and acceptability of artemether-lumefantrine as first-line anti-malarial treatment: evidence from a rural community in Tanzania. Malar J 9: 48.
Beer N, Ali AS, Rotllant G, Abass AK, Omari RS, Al-Mafazy AW, Bjorkman A, Kallander K, 2009. Adherence to artesunate-amodiaquine combination therapy for uncomplicated malaria in children in Zanzibar, Tanzania. Trop Med Int Health 14: 766–774.
Yeung S, White NJ, 2005. How do patients use antimalarial drugs? A review of the evidence. Trop Med Int Health 10: 121–138.
Liberati A, Altman DG, Tetzlaff J, Mulrow C, Gotzsche PC, Ioannidis JP, Clarke M, Devereaux PJ, Kleijnen J, Moher D, 2009. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate healthcare interventions: explanation and elaboration. BMJ 339: b2700.
Higgins JPT, Green S, 2011. Cochrane Handbook for Systematic Reviews of Interventions Version 5.1.0. Available at: www.cochrane-handbook.org. Accessed March 1, 2013.
Higgins JPT, Green S, 2008. Cochrane Handbook for Systematic Reviews of Interventions. Chichester: John Wiley & Son Ltd.
Jadad AR, Moore RA, Carroll D, Jenkinson C, Reynolds DJ, Gavaghan DJ, McQuay HJ, 1996. Assessing the quality of reports of randomized clinical trials: is blinding necessary? Control Clin Trials 17: 1–12.
Higgins JPT, Thompson SG, 2002. Quantifying heterogeneity in a meta-analysis. Stat Med 11: 1539–1558.
Deeks JJ, Higgins JPT, Altman DG (ed), 2008. Chapter 9: analysing data and undertaking meta-analyses. In: Higgins JPT, Green S (eds). Cochrane Handbook for Systematic Reviews of Interventions. Version 5.0.1 [updated September 2008]. The Cochrane Collaboration. Available at: www.cochrane-handbook.org.
Qingjun L, Jihui D, Laiyi T, Xiangjun Z, Jun L, Hay A, Shires S, Navaratnam V, 1998. The effect of drug packaging on patients' compliance with treatment for Plasmodium vivax malaria in China. Bull World Health Organ 76 (Suppl 1): 21–27.
Denis MB, 1998. Improving compliance with quinine + tetracycline for treatment of malaria: evaluation of health education interventions in Cambodian villages. Bull World Health Organ 76 (Suppl 1): 43–49.
Fungladda W, Honrado ER, Thimasarn K, Kitayaporn D, Karbwang J, Kamolratanakul P, Masngammueng R, 1998. Compliance with artesunate and quinine + tetracycline treatment of uncomplicated falciparum malaria in Thailand. Bull World Health Organ 76 (Suppl 1): 59–66.
Ansah EK, Gyapong JO, Agyepong IA, Evans DB, 2001. Improving adherence to malaria treatment for children: the use of pre-packed chloroquine tablets vs. chloroquine syrup. Trop Med Int Health 6: 496–504.
Yeboah-Antwi K, Gyapong JO, Asare IK, Barnish G, Evans DB, Adjei S, 2001. Impact of prepackaging antimalarial drugs on cost to patients and compliance with treatment. Bull World Health Organ 79: 394–399.
Okonkwo PO, Akpala CO, Okafor HU, Mbah AU, Nwaiwu O, 2001. Compliance to correct dose of chloroquine in uncomplicated malaria correlates with improvement in the condition of rural Nigerian children. Trans R Soc Trop Med Hyg 95: 320–324.
Winch PJ, Bagayoko A, Diawara A, Kane M, Thiero F, Gilroy K, Daou Z, Berthe Z, Swedberg E, 2003. Increases in correct administration of chloroquine in the home and referral of sick children to health facilities through a community-based intervention in Bougouni District, Mali. Trans R Soc Trop Med Hyg 97: 481–490.
Agyepong IA, Ansah E, Gyapong M, Adjei S, Barnish G, Evans D, 2002. Strategies to improve adherence to recommended chloroquine treatment regimes: a quasi-experiment in the context of integrated primary health care delivery in Ghana. Soc Sci Med 55: 2215–2226.
Afenyadu GY, Agyepong IA, Barnish G, Adjei S, 2005. Improving access to early treatment of malaria: a trial with primary school teachers as care providers. Trop Med Int Health 10: 1065–1072.
Achan J, Tibenderana JK, Kyabayinze D, Wabwire Mangen F, Kamya MR, Dorsey G, D'Alessandro U, Rosenthal PJ, Talisuna AO, 2009. Effectiveness of quinine versus artemether-lumefantrine for treating uncomplicated falciparum malaria in Ugandan children: randomized trial. BMJ 339: b2763.
Lauwo JA, Hombhanje FW, Tulo SP, Maibani G, Bjorge S, 2006. Impact of pre-packaging antimalarial drugs and counseling on compliance with malaria treatment at Port Moresby General Hospital Adult Outpatient Department. P N G Med J 49: 14–21.
Rahman MM, Dondorp AM, Day NPJ, Lindegardh N, Imwong M, Faiz MA, Bangali AM, Kamal AT, Karim J, Kaewkungwal J, Singhasivanon P, 2008. Adherence and efficacy of supervised versus non-supervised treatment with artemether/lumefantrine for the treatment of uncomplicated Plasmodium falciparum malaria in Bangladesh: a randomized controlled trial. Trans R Soc Trop Med Hyg 102: 861–867.
Faucher JF, Aubouy A, Adeothy A, Cottrell G, Doritchamou J, Gourmel B, Houze P, Kossou H, Amedome H, Massougbodji A, Cot M, Deloron P, 2009. Comparison of sulfadoxine-pyrimethamine, unsupervised artemether-lumefantrine, and unsupervised artesunate-amodiaquine fixed-dose formulation for uncomplicated Plasmodium falciparum malaria in Benin: a randomized effectiveness noninferiority trial. J Infect Dis 200: 57–65.
Takeuchi R, Lawpoolsri S, Imwong M, Kobayashi J, Kaewkungwal J, Pukrittayakamee S, Puangsa-Art S, Thanyavanich N, Maneeboonyang W, Day NP, Singhasivanon P, 2010. Directly-observed therapy (DOT) for the radical 14-day primaquine treatment of Plasmodium vivax malaria on the Thai-Myanmar border. Malar J 9: 308.
Dunyo S, Sirugo G, Sesay S, Bisseye C, Njie F, Adiamoh M, Nwakanma D, Diatta M, Janha R, Sisay Joof F, Temple B, Snell P, Conway D, Walton R, Cheung YB, Milligan P, 2011. Randomized trial of safety and effectiveness of chlorproguanil-dapsone and lumefantrine-artemether for uncomplicated malaria in children in the Gambia. PLoS ONE 6: e17371.
Kangwana BP, Kedenge SV, Noor AM, Alegana VA, Nyandigisi AJ, Pandit J, Fegan GW, Todd JE, Brooker S, Snow RW, Goodman CA, 2011. The impact of retail-sector delivery of artemether-lumefantrine on malaria treatment of children under five in Kenya: a cluster randomized controlled trial. PLoS Med 8: e1000437.
Krueger KP, Berger BA, Felkey B, 2005. Medication adherence and persistence: a comprehensive review. Adv Ther 22: 313–356.
Berben L, Bogert L, Leventhal ME, Fridlund B, Jaarsma T, Norekval TM, Smith K, Stromberg A, Thompson DR, De Geest S, 2011. Which interventions are used by health care professionals to enhance medication adherence in cardiovascular patients? A survey of current clinical practice. Eur J Cardiovasc Nurs 10: 14–21.
Wu YP, Roberts MC, 2008. A meta-analysis of interventions to increase adherence to medication regimens for pediatric otitis media and streptococcal pharyngitis. J Pediatr Psychol 33: 789–796.
Fjeldsoe BS, Marshall AL, Miller YD, 2009. Behavior change interventions delivered by mobile telephone short-message service. Am J Prev Med 36: 165–173.
Meankaew P, Kaewkungwal J, Khamsiriwatchara A, Khunthong P, Singhasivanon P, Satimai W, 2010. Application of mobile-technology for disease and treatment monitoring of malaria in the “Better Border Healthcare Programme”. Malar J 10: 69.
Bowry AD, Shrank WH, Lee JL, Stedman M, Choudhry NK, 2011. A systematic review of adherence to cardiovascular medications in resource-limited settings. J Gen Intern Med 26: 1479–1491.
Sandercock P, 2011. The authors say: ‘The data are not so robust because of heterogeneity’ - so, how should I deal with this systematic review? Meta-analysis and the clinician. Cerebrovasc Dis 31: 615–620.
Twagirumukiza M, Kayumba PC, Kips JG, Vrijens B, Stichele RV, Vervaet C, Remon JP, Van Bortel ML, 2010. Evaluation of medication adherence methods in the treatment of malaria in Rwandan infants. Malar J 9: 206.
Moher D, Hopewell S, Schulz KF, Montori V, Gotzsche PC, Devereaux PJ, Elbourne D, Egger M, Altman DG, 2010. CONSORT 2010 Explanation and Elaboration: updated guidelines for reporting parallel group randomized trials. J Clin Epidemiol 63: e1–e37.
Velligan D, Sajatovic M, Valenstein M, Riley WT, Safren S, Lewis-Fernandez R, Weiden P, Ogedegbe G, Jamison J, 2010. Methodological challenges in psychiatric treatment adherence research. Clin Schizophr Relat Psychoses 4: 74–91.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 472 | 267 | 27 |
Full Text Views | 419 | 22 | 1 |
PDF Downloads | 166 | 23 | 1 |