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Of 214 children with hookworm infection in Lowndes County, Georgia, 80 were treated with tetrachloroethylene, 95 with one, two, or three doses of bephenium, and 39 were not treated. Following treatment, percentage reductions in mean egg counts were approximately 99, 89, 84, 64 and 50, respectively; and percentages of children completely cleared were 81, 29, 30, 16 and 26, respectively. It was concluded that bephenium possessed some anthelmintic activity but that tetrachloroethylene was superior. Side effects were more commonly produced by the bephenium preparation than by the tetrachloroethylene.