Out-Patient Tolerance and Anthelminthic Activity of New Formulations of Dithiazanine

Francisco Febles Jr.
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M. M. Brooke
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Carl C. Janowsky
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A. M. Perri
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Summary

New formulations of dithiazanine with longer disintegration times than those of the present commercial product were found to be significantly better tolerated by Puerto Rican residents of Philadelphia treated as outpatients in a city clinic. The formulation with the longest disintegration time (60–90 minutes) was tolerated practically as well as the placebo.

The anthelminthic effect of the new formulations was observed to be equal to that of the present commercial product as measured against infections of Trichuris trichiura. Not enough infections of Ascaris lumbricoides, hookworm, and Strongyloides stercoralis were included in the study to determine the broad spectrum effect of the new formulations.

Author Notes

Communicable Disease Center, Public Health Service, Department of Health, Education, and Welfare, Atlanta, Georgia, and Philadelphia, Pennsylvania.

Director, Division of Epidemiology, Philadelphia Department of Public Health, Philadelphia.

Deceased. Formerly Director of Health District #6, Philadelphia Department of Public Health, Philadelphia.

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