The Use of Dithiazanine as a Mass Treatment for Intestinal Helminthiasis

Laureano GuerreroDepartment of Parasitology, University of Antioquia, School of Medicine, Medellín, Colombia

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Jorge HolguinDepartment of Parasitology, University of Antioquia, School of Medicine, Medellín, Colombia

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David BoteroDepartment of Parasitology, University of Antioquia, School of Medicine, Medellín, Colombia

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Summary

In Medellín, Colombia, 362 persons were studied by means of stool examinations, and 87.2% of them were positive for intestinal helminths. A total of 273 persons, ranging in age from 18 months to 68 years, were treated with dithiazanine iodide with the daily dosage of 200 mg under 15 kg of body weight, 400 mg between 16 and 30 kg and 600 mg over 30 kg, all for 8 days.

The majority of the 273 persons treated had more than one species of helminth. The number of infections in the group was 508, caused by Ascaris lumbricoides, Trichuris trichiura, Strongyloides stercoralis and Necator americanus. Post-treatment examination revealed eradication of 372 infections, or 73.2%, cured. In the remaining 136 infections, the worm burdens were decreased considerably, for the average egg count per gram of feces was reduced from 9,637 to 2,280, i.e., 76.4%. Intolerance to the drug was observed in 43.5% of the cases. The reaction of cases ceased with simple treatment or spontaneously.

From this report the conclusion is drawn that dithiazanine iodide is effective for mass treatment of intestinal helminths common in Colombia.

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