Author:
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
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-
1.
Colombo AL, Tobón A, Restrepo A, Queiroz-Telles F, Nucci M, 2002. Epidemiology of endemic systemic fungal infections in Latin America. Med Mycol 49: 785–798.
-
2.
Jiménez R, Tobon AM, Bedoya F, Restrepo A, 2002. Histoplasmosis crónica diseminada en un paciente no inmunocomprometido. Medicina UPB 21: 57–66.
-
3.
Kauffman CA, 2007. Histoplasmosis: a clinical and laboratory update. Clin Microbiol Rev 20: 115–132.
-
4.
Hage CA, Wheat LJ, Lloyd J, Allen SD, Blue D, Knox KS, 2008. Pulmonary histoplasmosis. Semin Respir Crit Care Med 29: 151–165.
-
5.
Couppie P, Aznar C, Carme B, Nacher M, 2006. American histoplasmosis in developing countries with a special focus on patients with HIV: diagnosis, treatment and prognosis. Curr Opin Infect Dis 19: 443–449.
-
6.
Torres JM, Ribas E, Gascón J, López O, Espasa M, 2000. Utilidad diagnóstica de la prueba intradérmica con histoplasmina, en áreas no endémicas de histoplasmosis. Rev Iberoam Micol 17: 97–101.
-
7.
Arango M, de Bedout C, Tobón AM, Restrepo A, Torrado E, Castañeda E, Sierra P, González GA, Panesso R, Cárdenas J, Estrada S, Jaramillo E; The Colombian Histoplasmosis Study Group, 2000. Histoplasmosis en Colombia: Estudio Interinstitucional. Informe Quincenal Epidemiol Nacional 5: 119–123.
-
8.
Smith JA, Kauffman CA, 2012. Pulmonary fungal infectons. Respirology 17: 913–926.
-
9.
Ramos-e-Silva M, Lima CM, Schechtman RC, Trope BM, Carneiro S, 2012. Systemic mycoses in immunodepressed patients (AIDS). Clin Dermatol 30: 616–627.
-
10.
Chu JH, Feudtner C, Heydon K, Walsh TJ, Zaoutis TE, 2006. Hospitalizations for endemic mycoses: a population-based national study. Clin Infect Dis 42: 822–825.
-
11.
Kauffman CA, 2008. Diagnosis of histoplasmosis in immunosuppressed patients. Curr Opin Infect Dis 21: 421–425.
-
12.
Karimi K, Wheat LJ, Conolly P, Cloud G, Hajjeh R, Wheat E, Alves K, Lacaz Cd Cda S, Keath E, 2002. Differences in histoplasmosis in patients with acquired immunodeficiency syndrome in the United States and Brazil. J Infect Dis 186: 1655–1660.
-
13.
Hajjeh RA, Pappas PG, Henderson HD, Lancaster DM, Bamberger KJ, Skahan KJ, Phelan MA, Cloud G, Holloway M, Kauffman CA, Wheat LJ; National Institute of Allergy and Infectious Diseases Mycoses Study Group, 2001. Multicenter case-control study of risk factors for histoplasmosis in human immunodeficiency virus-infected people. Clin Infect Dis 32: 1215–1220.
-
14.
Guimaraes AJ, Nosanchuk JD, Zancope-Oliveira RM, 2006. Diagnosis of histoplasmosis. Braz J Microbiol 37: 1–13.
-
15.
Wheat LJ, Kauffman CA, 2003. Histoplasmosis. Infect Dis Clin North Am 17: 1–19.
-
16.
Wheat LJ, 2006. Improvements in diagnosis of histoplasmosis. Expert Opin Biol Ther 6: 1207–1221.
-
17.
Arango M, Castañeda E, Agudelo CI, de Bedout C, Agudelo CA, Tobón A, Linares M, Valencia Y, Restrepo A; Colombian Histoplasmosis Study Group, 2011. Histoplasmosis: results of the Colombian national survey, 1992–2008. Biomedica 31: 344–356.
-
18.
Ordoñez N, Tobón A, Arango M, Tabares A, de Bedout C, Gomez B, Castañeda E, Restrepo A, 1997. Brotes de histoplasmosis registrados en el área andina colombiana. Biomedica 17: 105–111.
-
19.
Ashbee HR, Evans EG, Viviani MA, Dupont B, Chryssanthou E, Surmont I, Tomsikova A, Vachkov P, Enero B, Zala J, Tintelnot K; ECMM Working Group on Histoplasmosis, 2008. Histoplasmosis in Europe: report on an epidemiological survey from the European Confederation of Medical Mycology Working Group. Med Mycol 46: 57–65.
-
20.
Tobón AM, Agudelo CA, Rosero DS, Ochoa JE, de Bedout C, Zuluaga A, Arango M, Cano LE, Sampedro J, Restrepo A, 2005. Disseminated histoplasmosis: a comparative study between patients with acquired immunodeficiency sindrome and non-human immunodeficieny virus-infected individuals. Am J Trop Med Hyg 73: 576–582.
-
21.
Tobón A, Franco I, Correa AL, Bedoya F, Ortiga J, Soto M, 1997. Histoplasmosis en el adulto. Acta Med Colomb 22: 277–284.
-
22.
Huber F, Nacher M, Aznar C, Pierre-Demar M, el Guedj M, Vaz T, Vantilcke V, Mahamat A, Magnien C, Chauvet E, Carme B, Couppié P, 2008. AIDS-related Histoplasma capsulatum var. capsulatum infection: 25 years experience of French Guiana. AIDS 22: 1047–1053.
-
23.
Bravo IM, Correnti M, Escalona L, Perrone M, Brito A, Tovar V, Rivera H, 2006. Prevalence of oral lesions in HIV patients related to CD4 cell count and viral load in a Venezuelan population. Med Oral Patol Oral Cir Bucal 11: 33–39.
-
24.
Vail GM, Mocherla S, Wheat LJ, Goldberg J, Camp A, Brizendine E, Schnizlein-Bick C, 2002. Cellular immune response in HIV-infected patients with histoplasmosis. J Acquir Immune Defic Syndr 29: 49–53.
-
25.
Wheat LJ, 2003. Current diagnosis of histoplasmosis. Trends Microbiol 11: 488–494.
-
26.
Wheat J, 1996. Histoplasmosis in the acquired immunodeficiency syndrome. Curr Top Med Mycol 7: 7–18.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 739 | 645 | 70 |
| Full Text Views | 420 | 12 | 2 |
| PDF Downloads | 153 | 8 | 0 |
Diagnostic Value of Culture and Serological Tests in the Diagnosis of Histoplasmosis in HIV and non-HIV Colombian Patients
Karen Arango-Bustamante
Karen Arango-Bustamante
Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia; Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia; Basic and Applied Microbiology Research Group (MICROBA), Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia
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Angela Restrepo
Angela Restrepo
Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia; Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia; Basic and Applied Microbiology Research Group (MICROBA), Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia
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Luz Elena Cano
Luz Elena Cano
Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia; Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia; Basic and Applied Microbiology Research Group (MICROBA), Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia
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Catalina de Bedout
Catalina de Bedout
Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia; Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia; Basic and Applied Microbiology Research Group (MICROBA), Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia
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Angela Maria Tobón
Angela Maria Tobón
Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia; Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia; Basic and Applied Microbiology Research Group (MICROBA), Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia
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Angel González
Angel González
Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia; Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia; Basic and Applied Microbiology Research Group (MICROBA), Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia
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We determined the value of culture and serological tests used to diagnose histoplasmosis. The medical records of 391 histoplasmosis patients were analyzed. Diagnosis of the mycosis was assessed by culture, complement fixation, and immunodiffusion tests; 310 patients (79.5%) were male, and 184 patients (47.1%) were infected with human immunodeficiency virus (HIV). Positivity value for cultures was 35.7% (74/207), reactivity of serological tests was 95.2% (160/168), and a combination of both methodologies was 16.9% (35/207) for non-HIV patients. Positivity value for cultures was 75.0% (138/184), reactivity of serological tests was 92.4% (85/92), and a combination of both methodologies was 26.0% (48/184) for HIV/acquired immunodeficiency syndrome (AIDS) patients; 48.1% (102/212) of extrapulmonary samples from HIV/AIDS patients yielded positive cultures compared with 23.1% (49/212) in non-HIV patients. Lymphocyte counts made for 33.1% (61/184) of HIV/AIDS patients showed a trend to low CD4+ numbers and higher proportion of positive cultures. These results indicate that culture is the most reliable fungal diagnostic method for HIV/AIDS patients, and contrary to what is generally believed, serological assays are useful for diagnosing histoplasmosis in these patients.
Author Notes
Authors' addresses: Karen Arango-Bustamante, Angela Restrepo, Catalina de Bedout, and Angela Maria Tobón, Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia, E-mails: Karen.arango@gmail.com, angelares@une.net.co, cbedout@cib.org.co, and atobon@cib.org.co. Luz Elena Cano, Medical and Experimental Mycology Group, Corporación para Investigaciones Biológicas (CIB), Medellín, Colombia and Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia, E-mail: lcano@cib.org.co. Angel González, Basic and Applied Microbiology Research Group (MICROBA), Escuela de Microbiología, Universidad de Antioquia, Medellín, Colombia, E-mail: angelgonzalezmarin1972@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Colombo AL, Tobón A, Restrepo A, Queiroz-Telles F, Nucci M, 2002. Epidemiology of endemic systemic fungal infections in Latin America. Med Mycol 49: 785–798.
-
2.
Jiménez R, Tobon AM, Bedoya F, Restrepo A, 2002. Histoplasmosis crónica diseminada en un paciente no inmunocomprometido. Medicina UPB 21: 57–66.
-
3.
Kauffman CA, 2007. Histoplasmosis: a clinical and laboratory update. Clin Microbiol Rev 20: 115–132.
-
4.
Hage CA, Wheat LJ, Lloyd J, Allen SD, Blue D, Knox KS, 2008. Pulmonary histoplasmosis. Semin Respir Crit Care Med 29: 151–165.
-
5.
Couppie P, Aznar C, Carme B, Nacher M, 2006. American histoplasmosis in developing countries with a special focus on patients with HIV: diagnosis, treatment and prognosis. Curr Opin Infect Dis 19: 443–449.
-
6.
Torres JM, Ribas E, Gascón J, López O, Espasa M, 2000. Utilidad diagnóstica de la prueba intradérmica con histoplasmina, en áreas no endémicas de histoplasmosis. Rev Iberoam Micol 17: 97–101.
-
7.
Arango M, de Bedout C, Tobón AM, Restrepo A, Torrado E, Castañeda E, Sierra P, González GA, Panesso R, Cárdenas J, Estrada S, Jaramillo E; The Colombian Histoplasmosis Study Group, 2000. Histoplasmosis en Colombia: Estudio Interinstitucional. Informe Quincenal Epidemiol Nacional 5: 119–123.
-
8.
Smith JA, Kauffman CA, 2012. Pulmonary fungal infectons. Respirology 17: 913–926.
-
9.
Ramos-e-Silva M, Lima CM, Schechtman RC, Trope BM, Carneiro S, 2012. Systemic mycoses in immunodepressed patients (AIDS). Clin Dermatol 30: 616–627.
-
10.
Chu JH, Feudtner C, Heydon K, Walsh TJ, Zaoutis TE, 2006. Hospitalizations for endemic mycoses: a population-based national study. Clin Infect Dis 42: 822–825.
-
11.
Kauffman CA, 2008. Diagnosis of histoplasmosis in immunosuppressed patients. Curr Opin Infect Dis 21: 421–425.
-
12.
Karimi K, Wheat LJ, Conolly P, Cloud G, Hajjeh R, Wheat E, Alves K, Lacaz Cd Cda S, Keath E, 2002. Differences in histoplasmosis in patients with acquired immunodeficiency syndrome in the United States and Brazil. J Infect Dis 186: 1655–1660.
-
13.
Hajjeh RA, Pappas PG, Henderson HD, Lancaster DM, Bamberger KJ, Skahan KJ, Phelan MA, Cloud G, Holloway M, Kauffman CA, Wheat LJ; National Institute of Allergy and Infectious Diseases Mycoses Study Group, 2001. Multicenter case-control study of risk factors for histoplasmosis in human immunodeficiency virus-infected people. Clin Infect Dis 32: 1215–1220.
-
14.
Guimaraes AJ, Nosanchuk JD, Zancope-Oliveira RM, 2006. Diagnosis of histoplasmosis. Braz J Microbiol 37: 1–13.
-
15.
Wheat LJ, Kauffman CA, 2003. Histoplasmosis. Infect Dis Clin North Am 17: 1–19.
-
16.
Wheat LJ, 2006. Improvements in diagnosis of histoplasmosis. Expert Opin Biol Ther 6: 1207–1221.
-
17.
Arango M, Castañeda E, Agudelo CI, de Bedout C, Agudelo CA, Tobón A, Linares M, Valencia Y, Restrepo A; Colombian Histoplasmosis Study Group, 2011. Histoplasmosis: results of the Colombian national survey, 1992–2008. Biomedica 31: 344–356.
-
18.
Ordoñez N, Tobón A, Arango M, Tabares A, de Bedout C, Gomez B, Castañeda E, Restrepo A, 1997. Brotes de histoplasmosis registrados en el área andina colombiana. Biomedica 17: 105–111.
-
19.
Ashbee HR, Evans EG, Viviani MA, Dupont B, Chryssanthou E, Surmont I, Tomsikova A, Vachkov P, Enero B, Zala J, Tintelnot K; ECMM Working Group on Histoplasmosis, 2008. Histoplasmosis in Europe: report on an epidemiological survey from the European Confederation of Medical Mycology Working Group. Med Mycol 46: 57–65.
-
20.
Tobón AM, Agudelo CA, Rosero DS, Ochoa JE, de Bedout C, Zuluaga A, Arango M, Cano LE, Sampedro J, Restrepo A, 2005. Disseminated histoplasmosis: a comparative study between patients with acquired immunodeficiency sindrome and non-human immunodeficieny virus-infected individuals. Am J Trop Med Hyg 73: 576–582.
-
21.
Tobón A, Franco I, Correa AL, Bedoya F, Ortiga J, Soto M, 1997. Histoplasmosis en el adulto. Acta Med Colomb 22: 277–284.
-
22.
Huber F, Nacher M, Aznar C, Pierre-Demar M, el Guedj M, Vaz T, Vantilcke V, Mahamat A, Magnien C, Chauvet E, Carme B, Couppié P, 2008. AIDS-related Histoplasma capsulatum var. capsulatum infection: 25 years experience of French Guiana. AIDS 22: 1047–1053.
-
23.
Bravo IM, Correnti M, Escalona L, Perrone M, Brito A, Tovar V, Rivera H, 2006. Prevalence of oral lesions in HIV patients related to CD4 cell count and viral load in a Venezuelan population. Med Oral Patol Oral Cir Bucal 11: 33–39.
-
24.
Vail GM, Mocherla S, Wheat LJ, Goldberg J, Camp A, Brizendine E, Schnizlein-Bick C, 2002. Cellular immune response in HIV-infected patients with histoplasmosis. J Acquir Immune Defic Syndr 29: 49–53.
-
25.
Wheat LJ, 2003. Current diagnosis of histoplasmosis. Trends Microbiol 11: 488–494.
-
26.
Wheat J, 1996. Histoplasmosis in the acquired immunodeficiency syndrome. Curr Top Med Mycol 7: 7–18.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 739 | 645 | 70 |
| Full Text Views | 420 | 12 | 2 |
| PDF Downloads | 153 | 8 | 0 |