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Predictive Factors of HTLV1-HIV Coinfections in French Guiana

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  • Departement des Maladies Infectieuses, Cayenne General Hospital, French Guiana; COREVIH Guyane, Cayenne General Hospital, French Guiana; Department of Dermatology, Cayenne General Hospital, Cayenne, French Guiana; Centre d'Investigation Clinique Epidémiologie Clinique Antilles Guyane CIC-EC CIE INSERM 802, Cayenne General Hospital, Cayenne, French Guiana; Equipe EPaT EA3593 Epidemiologie des Parasitoses et Mycoses Tropicales, Universite Antilles Guyane; Equipe EA 3593, Université des Antilles et de la Guyane

French Guiana, the French territory most affected by human immunodeficiency virus (HIV) (1.3% of pregnant women), is also endemic for human T lymphotropic virus 1 (HTLV1). The objective of this study was to determine if the HTLV1/HIV coinfected patients had particular characteristics. All HIV-infected patients having a computerized medical file containing an HTLV1 serology were included: there were 1,333 HIV monoinfections and 76 HTLV1/VIH coinfections. The prevalence of HTLV1/HIV coinfections was 5.39%. Women (odds ratio [OR] = 1.91[1.13–3.24]), subjects > 40 years of age, and patients of Surinamese origin (OR = 2.65 [1.25–5.61]) were overrepresented among the coinfected. CD4 count at the time of diagnosis and viral loads were higher among coinfected patients. The clinical stage was not significantly different between the two groups. The number of CD4 cells was not higher among the coinfected, unlike most reports from the literature. Prevalence of HTLV1 among HIV-infected patients is high in French Guiana, and physicians seem to omit the prescription of serology for this potentially serious coinfection.

Author Notes

* Address correspondence to Mathieu Nacher, CH Cayenne, Rue des Flamboyants, Cayenne, 97300. E-mail: mathieu.nacher@ch-cayenne.fr

Authors' addresses: Elise Gouhier and Philippe Abboud, Centre Hospitalier de Cayenne, Departement des Maladies Infectieuses, Cayenne, French Guiana, E-mails: elisegouhier@hotmail.com and philippe.abboud@ch-cayenne.fr. Emilie Gaubert-Maréchal, Centre Hospitalier de Cayenne – COREVIH, Cayenne, French Guiana, E-mail: emilie.gaubert-maréchal@ch-cayenne.fr. Pierre Couppié, Centre Hospitalier de Cayenne, Cayenne, French Guiana, Service de Dermatologie, Cayenne, French Guiana, E-mail: couppie.pierre@voila.fr. Mathieu Nacher, CH Cayenne, Rue des Flamboyants, Cayenne, E-mail: mathieu.nacher@ch-cayenne.fr.

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