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Reference Manager
BibTeX
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-
1.
Linthicum KJ, Davies FG, Kairo A, Bailey CL, 1985. Rift Valley Fever virus (family Bunyaviridae, genus Phlebovirus). Isolations from Diptera collected during an inter-epizootic period in Kenya. J Hyg (Lond) 95: 197–209.
-
2.
Laughlin LW, Meegan JM, Strausbaugh LJ, 1979. Epidemic Rift Valley Fever in Egypt: observations of the spectrum of human illness. Trans R Soc Trop Med Hyg 73: 630–633.
-
3.
Al-Hazmi M, Ayoola EA, Abdurahman M, Banzal S, Ashraf J, El-Bushra A, Abdullah M, Abbo H, Elamin A, Al-Sammani el-T, Gadour M, Menon C, Hamza M, Rahim I, Hafez M, Jambavalikar M, Arishi H, Ageel A, 2003. Epidemic Rift Valley fever in Saudi Arabia: a clinical study of severe illness in humans. Clin Infect Dis 36: 245–252.
-
4.
Al-Hazmi A, Al-Rajhi AA, Abboud EB, Ayoola EA, Al-Hazmi M, Saadi R, Ahmed N, 2005. Ocular Complications of Rift Valley Fever outbreak in Saudi Arabia. Ophthalmology 112: 313–318.
-
5.
LaBeaud AD, Muiruri S, Sutherland LJ, Dahir S, Gildengorin G, Morrill J, Muchiri EM, Peters CJ, King CH, 2011. Postepidemic analysis of Rift Valley Fever virus transmission in northeastern Kenya: a village cohort study. PLoS Negl Trop Dis 5: e1265.
-
6.
LaBeaud AD, Muchiri EM, Ndzovu M, Mwanje MT, Muiruri S, Peters CJ, King CH, 2008. Interepidemic Rift Valley Fever virus seropositivity, northeastern Kenya. Emerg Infect Dis 14: 1240–1246.
-
7.
Woods CW, Karpati AM, Grein T, McCarthy N, Gaturuku P, Muchiri E, Dunster L, Henderson A, Khan AS, Swanepoel R, Bonmarin I, Martin L, Smoak BL, Ryan M, Ksiazek TG, Arthur RR, Ndikuyeze A, Agata NN, Peters CJ, World Health Organization Hemorrhagic Fever Task Force, 2002. An outbreak of Rift Valley Fever in northeastern Kenya, 1997–98. Emerg Infect Dis 8: 138–144.
-
8.
Centers for Disease Control and Prevention, 2000. Outbreak of Rift Valley Fever–Yemen, August–October 2000. MMW Morb Mortal Wkly Rep 49: 1065–1066.
-
9.
World Health Organization, 2007. Outbreaks of Rift Valley Fever in Kenya, Somalia and United Republic of Tanzania, December 2006–April 2007. Wkly Epidemiol Rec 82: 169–178.
-
10.
Siam AL, Meegan JM, 1980. Ocular disease resulting from infection with Rift Valley Fever virus. Trans R Soc Trop Med Hyg 74: 539–541.
-
11.
Hassan OA, Ahlm C, Sang R, Evander M, 2011. The 2007 Rift Valley Fever outbreak in Sudan. PLoS Negl Trop Dis 5: e1229.
-
12.
Centers for Disease Control and Prevention, 2007. Rift Valley Fever. Viral Hemorrhagic Fevers: Fact Sheets. Atlanta, GA: Centers for Disease Control and Prevention, 1–3.
-
13.
Pepin M, Bouloy M, Bird BH, Kemp A, Paweska J, 2010. Rift Valley Fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention. Vet Res 41: 61.
-
14.
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ, 2001. Immunobiology: The Immune System in Health and Disease, fifth edition. New York: Garland Science.
-
15.
Galindo-Cardiel I, Busquetes N, Velarde R, Abad FX, Solanes D, Rivas R, Valle R, Brun A, Domingo M, 2012. Lymphoplasmacytic endotheliitis and anterior uveitis in sheep infected experimentally with Rift Valley Fever virus. J Comp Pathol 146: 40–43.
-
16.
Khairallah M, Jelliti B, Jenzeri S, 2009. Emergent infectious uveitis. Middle East Afr J Ophthalmol 16: 225–238.
-
17.
Shimazaki K, Jirawuthiworavong GV, Heckenlively JR, Gordon LK, 2008. Frequency of anti-retinal antibodies in normal human serum. J Neuroophthalmol 28: 5–11.
-
18.
Von Teichman B, Engelbrecht A, Zulu G, Dungu B, Pardini A, Bouloy M, 2011. Safety and efficacy of Rift Valley Fever Smithburn and Clone 13 vaccines in calves. Vaccine 29: 5771–5777.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 219 | 172 | 3 |
| Full Text Views | 348 | 13 | 0 |
| PDF Downloads | 101 | 12 | 0 |
Potential for Autoimmune Pathogenesis of Rift Valley Fever Virus Retinitis
Shoshana Newman-Gerhardt
Shoshana Newman-Gerhardt
Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California; Division of Vector-Borne and Neglected Tropical Diseases, Ministry of Health, Nairobi, Kenya; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; Center for Global Health and Disease, Case Western Reserve University, Cleveland, Ohio
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Samuel Muiruri
Samuel Muiruri
Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California; Division of Vector-Borne and Neglected Tropical Diseases, Ministry of Health, Nairobi, Kenya; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; Center for Global Health and Disease, Case Western Reserve University, Cleveland, Ohio
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Eric Muchiri
Eric Muchiri
Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California; Division of Vector-Borne and Neglected Tropical Diseases, Ministry of Health, Nairobi, Kenya; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; Center for Global Health and Disease, Case Western Reserve University, Cleveland, Ohio
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Clarence J. Peters
Clarence J. Peters
Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California; Division of Vector-Borne and Neglected Tropical Diseases, Ministry of Health, Nairobi, Kenya; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; Center for Global Health and Disease, Case Western Reserve University, Cleveland, Ohio
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John Morrill
John Morrill
Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California; Division of Vector-Borne and Neglected Tropical Diseases, Ministry of Health, Nairobi, Kenya; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; Center for Global Health and Disease, Case Western Reserve University, Cleveland, Ohio
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Alexander H. Lucas
Alexander H. Lucas
Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California; Division of Vector-Borne and Neglected Tropical Diseases, Ministry of Health, Nairobi, Kenya; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; Center for Global Health and Disease, Case Western Reserve University, Cleveland, Ohio
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Charles H. King
Charles H. King
Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California; Division of Vector-Borne and Neglected Tropical Diseases, Ministry of Health, Nairobi, Kenya; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; Center for Global Health and Disease, Case Western Reserve University, Cleveland, Ohio
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James Kazura
James Kazura
Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California; Division of Vector-Borne and Neglected Tropical Diseases, Ministry of Health, Nairobi, Kenya; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; Center for Global Health and Disease, Case Western Reserve University, Cleveland, Ohio
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Angelle Desiree LaBeaud
Angelle Desiree LaBeaud
Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, California; Division of Vector-Borne and Neglected Tropical Diseases, Ministry of Health, Nairobi, Kenya; Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, Texas; Center for Global Health and Disease, Case Western Reserve University, Cleveland, Ohio
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Rift Valley Fever (RVF) is a significant threat to human health because it can progress to retinitis, encephalitis, and hemorrhagic fever. The timing of onset of Rift Valley Fever virus (RVFV) retinitis suggests an autoimmune origin. To determine whether RVFV retinitis is associated with increased levels of IgG against retinal tissue, we measured and compared levels of IgG against healthy human eye tissue by immunohistochemical analysis. We found that serum samples from RVFV-exposed Kenyans with retinitis (n = 8) were slightly more likely to have antibodies against retinal tissue than control populations, but the correlation was not statistically significant. Further investigation into the possible immune pathogenesis of RVFV retinitis could lead to improved therapies to prevent or treat this severe complication.
Author Notes
Financial support: This study was supported by the National Institutes of Health grant U54AI057160; the Midwest Regional Center of Excellence Program Project Award, International Collaborations in Infectious Disease Research ICIDR Biodefense Supplement grant U01AI45473, the Robert E. Shope International Fellowship in Infectious Diseases, and the Center for Immunobiology and Vaccine Development at Children's Hospital Oakland Research Institute.
Authors' addresses: Shoshana Newman-Gerhardt, National Institutes of Health, Bethesda, MD, E-mail: snhypheng@gmail.com. Samuel Muiruri, Division of Vector-Borne and Neglected Tropical Diseases, Ministry of Health, Nairobi, Kenya, E-mail: muiruri1001@yahoo.com. Eric Muchiri, Division of Vector Borne and Neglected Diseases, Ministry of Public Health and Sanitation, Nairobi, Kenya, E-mail: ericmmuchiri@gmail.com. Clarence J. Peters, Department of Pathology, University of Texas Medical Branch, Galveston, TX, E-mail: cjpeters@utmb.edu. John Morrill, Department of Microbiology and Immunology, University of Texas Medical Branch, Galveston, TX, E-mail: jcmorril@utmb.edu. Alexander H. Lucas and Angelle Desiree LaBeaud, Center for Immunobiology and Vaccine Development, Children's Hospital Oakland Research Institute, Oakland, CA, E-mails: alucas@chori.org and alabeaud@chori.org. Charles H. King and James Kazura, Center for Global Health, Case Western Reserve University, Cleveland, OH, E-mails: chk@case.edu and jxk14@po.cwru.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Linthicum KJ, Davies FG, Kairo A, Bailey CL, 1985. Rift Valley Fever virus (family Bunyaviridae, genus Phlebovirus). Isolations from Diptera collected during an inter-epizootic period in Kenya. J Hyg (Lond) 95: 197–209.
-
2.
Laughlin LW, Meegan JM, Strausbaugh LJ, 1979. Epidemic Rift Valley Fever in Egypt: observations of the spectrum of human illness. Trans R Soc Trop Med Hyg 73: 630–633.
-
3.
Al-Hazmi M, Ayoola EA, Abdurahman M, Banzal S, Ashraf J, El-Bushra A, Abdullah M, Abbo H, Elamin A, Al-Sammani el-T, Gadour M, Menon C, Hamza M, Rahim I, Hafez M, Jambavalikar M, Arishi H, Ageel A, 2003. Epidemic Rift Valley fever in Saudi Arabia: a clinical study of severe illness in humans. Clin Infect Dis 36: 245–252.
-
4.
Al-Hazmi A, Al-Rajhi AA, Abboud EB, Ayoola EA, Al-Hazmi M, Saadi R, Ahmed N, 2005. Ocular Complications of Rift Valley Fever outbreak in Saudi Arabia. Ophthalmology 112: 313–318.
-
5.
LaBeaud AD, Muiruri S, Sutherland LJ, Dahir S, Gildengorin G, Morrill J, Muchiri EM, Peters CJ, King CH, 2011. Postepidemic analysis of Rift Valley Fever virus transmission in northeastern Kenya: a village cohort study. PLoS Negl Trop Dis 5: e1265.
-
6.
LaBeaud AD, Muchiri EM, Ndzovu M, Mwanje MT, Muiruri S, Peters CJ, King CH, 2008. Interepidemic Rift Valley Fever virus seropositivity, northeastern Kenya. Emerg Infect Dis 14: 1240–1246.
-
7.
Woods CW, Karpati AM, Grein T, McCarthy N, Gaturuku P, Muchiri E, Dunster L, Henderson A, Khan AS, Swanepoel R, Bonmarin I, Martin L, Smoak BL, Ryan M, Ksiazek TG, Arthur RR, Ndikuyeze A, Agata NN, Peters CJ, World Health Organization Hemorrhagic Fever Task Force, 2002. An outbreak of Rift Valley Fever in northeastern Kenya, 1997–98. Emerg Infect Dis 8: 138–144.
-
8.
Centers for Disease Control and Prevention, 2000. Outbreak of Rift Valley Fever–Yemen, August–October 2000. MMW Morb Mortal Wkly Rep 49: 1065–1066.
-
9.
World Health Organization, 2007. Outbreaks of Rift Valley Fever in Kenya, Somalia and United Republic of Tanzania, December 2006–April 2007. Wkly Epidemiol Rec 82: 169–178.
-
10.
Siam AL, Meegan JM, 1980. Ocular disease resulting from infection with Rift Valley Fever virus. Trans R Soc Trop Med Hyg 74: 539–541.
-
11.
Hassan OA, Ahlm C, Sang R, Evander M, 2011. The 2007 Rift Valley Fever outbreak in Sudan. PLoS Negl Trop Dis 5: e1229.
-
12.
Centers for Disease Control and Prevention, 2007. Rift Valley Fever. Viral Hemorrhagic Fevers: Fact Sheets. Atlanta, GA: Centers for Disease Control and Prevention, 1–3.
-
13.
Pepin M, Bouloy M, Bird BH, Kemp A, Paweska J, 2010. Rift Valley Fever virus (Bunyaviridae: Phlebovirus): an update on pathogenesis, molecular epidemiology, vectors, diagnostics and prevention. Vet Res 41: 61.
-
14.
Janeway CA Jr, Travers P, Walport M, Shlomchik MJ, 2001. Immunobiology: The Immune System in Health and Disease, fifth edition. New York: Garland Science.
-
15.
Galindo-Cardiel I, Busquetes N, Velarde R, Abad FX, Solanes D, Rivas R, Valle R, Brun A, Domingo M, 2012. Lymphoplasmacytic endotheliitis and anterior uveitis in sheep infected experimentally with Rift Valley Fever virus. J Comp Pathol 146: 40–43.
-
16.
Khairallah M, Jelliti B, Jenzeri S, 2009. Emergent infectious uveitis. Middle East Afr J Ophthalmol 16: 225–238.
-
17.
Shimazaki K, Jirawuthiworavong GV, Heckenlively JR, Gordon LK, 2008. Frequency of anti-retinal antibodies in normal human serum. J Neuroophthalmol 28: 5–11.
-
18.
Von Teichman B, Engelbrecht A, Zulu G, Dungu B, Pardini A, Bouloy M, 2011. Safety and efficacy of Rift Valley Fever Smithburn and Clone 13 vaccines in calves. Vaccine 29: 5771–5777.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 219 | 172 | 3 |
| Full Text Views | 348 | 13 | 0 |
| PDF Downloads | 101 | 12 | 0 |