Jentes ES, Poumerol G, Gershman MD, Hill DR, Lemarchand J, Lewis RF, Staples JE, Tomori O, Wilder-Smith A, Monath TP; Informal WHO Working Group on Geographic Risk for Yellow Fever, 2011. The revised global yellow fever risk map and recommendations for vaccination, 2010: consensus of the Informal WHO Working Group on Geographic Risk for Yellow Fever. Lancet Infect Dis 11: 622–632.
Wilson ME, Chen LH, Barnett ED, 2004. Yellow fever immunizations: indications and risks. Curr Infect Dis Rep 6: 34–42.
Barrett AD, Monath TP, Barban V, Niedrig M, Teuwen DE, 2007. 17D yellow fever vaccines: new insights. A report of a workshop held during the World Congress on medicine and health in the tropics, Marseille, France, Monday 12 September 2005. Vaccine 25: 2758–2765.
Staples JE, Gershman M, Fischer M; Centers for Disease Control and Prevention, 2010. Yellow fever vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 59: 1–27.
Wilder-Smith A, Hill DR, Freedman DO, 2008. The revised International Health Regulations (2005): impact on yellow fever vaccination in clinical practice. Am J Trop Med Hyg 78: 359–360.
Reinhardt B, Jaspert R, Niedrig M, Kostner C, L'Age-Stehr J, 1998. Development of viremia and humoral and cellular parameters of immune activation after vaccination with yellow fever virus strain 17D: a model of human flavivirus infection. J Med Virol 56: 159–167.
Gomez SY, Ocazionez RE, 2008. Yellow fever virus 17D neutralizing antibodies in vaccinated Colombian people and unvaccinated ones having immunity against dengue [in Spanish]. Rev Salud Publica (Bogota) 10: 796–807.
Groot H, Riberiro RB, 1962. Neutralizing and haemagglutination-inhibiting antibodies to yellow fever 17 year(s) after vaccination with 17D vaccine. Bull World Health Organ 27: 699–707.
Poland JD, Calisher CH, Monath TP, Downs WG, Murphy K, 1981. Persistence of neutralizing antibody 30–35 year(s) after immunization with 17D yellow fever vaccine. Bull World Health Organ 59: 895–900.
de Melo AB, da Silva M da P, Magalhaes MC, Gonzales Gil LH, Freese de Carvalho EM, Braga-Neto UM, Bertani GR, Marques ET Jr, Cordeiro MT, 2011. Description of a prospective 17DD yellow fever vaccine cohort in Recife, Brazil. Am J Trop Med Hyg 85: 739–747.
Rosenzweig EC, Babione RW, Wisseman CL Jr, 1963. Immunological studies with group B arthropod-borne viruses. IV. Persistence of yellow fever antibodies following vaccination with 17D strain yellow fever vaccine. Am J Trop Med Hyg 12: 230–235.
Niedrig M, Lademann M, Emmerich P, Lafrenz M, 1999. Assessment of IgG antibodies against yellow fever virus after vaccination with 17D by different assays: neutralization test, haemagglutination inhibition test, immunofluorescence assay and ELISA. Trop Med Int Health 4: 867–871.
Coulange Bodilis H, Benabdelmoumen G, Gergely A, Goujon C, Pelicot M, Poujol P, Consigny PH, 2011. Long term persistence of yellow fever neutralizing antibodies in elderly persons [in French]. Bull Soc Pathol Exot 104: 260–265.
Centers for Disease Control and Prevention, 2010. Transmission of yellow fever vaccine virus through breast-feeding–Brazil, 2009. MMWR Morb Mortal Wkly Rep 59: 130–132.
Kuhn S, Twele-Montecinos L, MacDonald J, Webster P, Law B, 2011. Case report: probable transmission of vaccine strain of yellow fever virus to an infant via breast milk. CMAJ 183: E243–E245.
Anonymous, 2011. Meeting of the Global Advisory Committee on Vaccine Safety, December 2010. Wkly Epidemiol Rec 86: 38–43.
Kengsakul K, Sathirapongsasuti K, Punyagupta S, 2002. Fatal myeloencephalitis following yellow fever vaccination in a case with HIV infection. J Med Assoc Thai 85: 131–134.
Mason RA, Tauraso NM, Ginn RK, O'Brien TC, Trimmer RW, 1972. Yellow fever vaccine. V. Antibody response in maonkeys inoculated with graded doses of the 17D vaccine. Appl Microbiol 23: 908–913.
Mason RA, Tauraso NM, Spertzel RO, Ginn RK, 1973. Yellow fever vaccine: direct challenge of monkeys given graded doses of 17D vaccine. Appl Microbiol 25: 539–544.
Staples JE, Gershman M, Fischer M; Centers for Disease Control and Prevention, 2010. Yellow fever vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 59: 1–27.
Julander JG, Trent DW, Monath TP, 2011. Immune correlates of protection against yellow fever determined by passive immunization and challenge in the hamster model. Vaccine 29: 6008–6016.
Hombach J, Solomon T, Kurane I, Jacobson J, Wood D, 2005. Report on a WHO consultation on immunological endpoints for evaluation of new Japanese encephalitis vaccines, WHO, Geneva, 2–3 September, 2004. Vaccine 23: 5205–5211.
Monath TP, 2005. Yellow fever vaccine. Expert Rev Vaccines 4: 553–574.
Hepburn MJ, Kortepeter MG, Pittman PR, Boudreau EF, Mangiafico JA, Buck PA, Norris SL, Anderson EL, 2006. Neutralizing antibody response to booster vaccination with the 17d yellow fever vaccine. Vaccine 24: 2843–2849.
Groot H, Gast-Galvis A, 1965. Observations on the 17 D virus vaccine against yellow fever, applied by cutaneous scarification [in Spanish]. Rev Invest (Guadalajara) 5: 5–25.
Guerra HL, Sardinha TM, da Rosa AP, Lima e Costa MF, 1997. Effectiveness of the yellow fever vaccine 17D: an epidemiologic evaluation in health services [in Spanish]. Rev Panam Salud Publica 2: 115–120.
Vazquez S, Valdes O, Pupo M, Delgado I, Alvarez M, Pelegrino JL, Guzmán MG, 2003. MAC-ELISA and ELISA inhibition methods for detection of antibodies after yellow fever vaccination. J Virol Methods 110: 179–184.
Camacho LA, Freire M da S, Leal M da L, Aguiar SG, Nascimento JP, Iguchi T, Lozana J de A, Farias RH; Collaborative Group for the Study of Yellow Fever Vaccines, 2004. Immunogenicity of WHO-17D and Brazilian 17DD yellow fever vaccines: a randomized trial. Rev Saude Publica 38: 671–678.
Tavares-Neto J, Freitas-Carvalho J, Nunes MR, Rocha G, Rodrigues SG, Damasceno E, Darub R, Viana S, Vasconcelos PF, 2004. Serologic survey for yellow fever and other arboviruses among inhabitants of Rio Branco, Brazil, before and three months after receiving the yellow fever 17D vaccine [in Portuguese]. Rev Soc Bras Med Trop 37: 1–6.
Belmusto-Worn VE, Sanchez JL, McCarthy K, Nichols R, Bautista CT, Magill AJ, Pastor-Cauna G, Echevarria C, Laguna-Torres VA, Samame BK, Baldeon ME, Burnas JP, Olson JG, Bedford P, Kitchener S, Monath TP, 2005. Randomized, double-blind, phase III, pivotal field trial of the comparative immunogenicity, safety, and tolerability of two yellow fever 17D vaccines (Arilvax and YF-VAX) in healthy infants and children in Peru. Am J Trop Med Hyg 72: 189–197.
Pfister M, Kursteiner O, Hilfiker H, Favre D, Durrer P, Ennaji A, L'Age-Stehr J, Kaufhold A, Herzog C, 2005. Immunogenicity and safety of BERNA-YF compared with two other 17D yellow fever vaccines in a phase 3 clinical trial. Am J Trop Med Hyg 72: 339–346.
Suzano CE, Amaral E, Sato HK, Papaiordanou PM; Campinas Group on Yellow Fever Immunization during Pregnancy, 2006. The effects of yellow fever immunization (17DD) inadvertently used in early pregnancy during a mass campaign in Brazil. Vaccine 24: 1421–1426.
Monath TP, Nichols R, Archambault WT, Moore L, Marchesani R, Tian J, Shope RE, Thomas N, Schrader R, Furby D, Bedford P, 2002. Comparative safety and immunogenicity of two yellow fever 17D vaccines (ARILVAX and YF-VAX) in a phase III multicenter, double-blind clinical trial. Am J Trop Med Hyg 66: 533–541.
Monath TP, 2001. Yellow fever: an update. Lancet Infect Dis 1: 11–20.
Niedrig M, Kursteiner O, Herzog C, Sonnenberg K, 2008. Evaluation of an indirect immunofluorescence assay for detection of immunoglobulin M (IgM) and IgG antibodies against yellow fever virus. Clin Vaccine Immunol 15: 177–181.
Wisseman CL Jr, Sweet BH, 1962. Immunological studies with group B arthropod-borne viruses. III. Response of human subjects to revaccination with 17D strain yellow fever vaccine. Am J Trop Med Hyg 11: 570–575.
Omilabu SA, Adejumo JO, Olaleye OD, Fagbami AH, Baba SS, 1990. Yellow fever haemagglutination-inhibiting, neutralising and IgM antibodies in vaccinated and unvaccinated residents of Ibadan, Nigeria. Comp Immunol Microbiol Infect Dis 13: 95–100.
Munoz-Jordan JL, Laurent-Rolle M, Ashour J, Martinez-Sobrido L, Ashok M, Lipkin WI, García-Sastre A, 2005. Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses. J Virol 79: 8004–8013.
Bonnevie-Nielsen V, Heron I, Monath TP, Calisher CH, 1995. Lymphocytic 2′,5′-oligoadenylate synthetase activity increases prior to the appearance of NTAbs and immunoglobulin M and immunoglobulin G antibodies after primary and secondary immunization with yellow fever vaccine. Clin Diagn Lab Immunol 2: 302–306.
Bruyand M, Receveur MC, Pistone T, Verdiere CH, Thiebaut R, Malvy D, 2008. Yellow fever vaccination in non-immunocompetent patients [in French]. Med Mal Infect 38: 524–532.
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Current regulations stipulate a yellow fever (YF) booster every 10 years. We conducted a systematic review of the protective efficacy and duration of immunity of YF vaccine in residents of disease-endemic areas and in travelers to assess the need for a booster in these two settings and in selected populations (human immunodeficiency virus–infected persons, infants, children, pregnant women, and severely malnourished persons). Thirty-six studies and 22 reports were included. We identified 12 studies of immunogenicity, 8 of duration of immunity, 8 of vaccine response in infants and children, 7 of human-immunodeficiency virus–infected persons, 2 of pregnant women, and 1 of severely malnourished children. Based on currently available data, a single dose of YF vaccine is highly immunogenic and confers sustained life-long protective immunity against YF. Therefore, a booster dose of YF vaccine is not needed. Special considerations for selected populations are detailed.
Disclosure: Eduardo Gotuzzo is an Advisory Board member and consultant for Pfizer and will participate in a study conducted by Sanofi Pasteur on the epidemiology of meningococcal infections.
Authors' addresses: Eduardo Gotuzzo and Erika Cordóva, Instituto de Medidina Tropical Alexander von Humbolt, Lima, Peru, E-mails: eduardo.gotuzzo@upch.pe and erika.cordova@upch.pe. Sergio Yactayo, Control of Epidemic Diseases, and Pandemic and Epidemic Diseases, World Health Organization, Geneva, Switzerland, E-mail: yactayos@who.int.
Jentes ES, Poumerol G, Gershman MD, Hill DR, Lemarchand J, Lewis RF, Staples JE, Tomori O, Wilder-Smith A, Monath TP; Informal WHO Working Group on Geographic Risk for Yellow Fever, 2011. The revised global yellow fever risk map and recommendations for vaccination, 2010: consensus of the Informal WHO Working Group on Geographic Risk for Yellow Fever. Lancet Infect Dis 11: 622–632.
Wilson ME, Chen LH, Barnett ED, 2004. Yellow fever immunizations: indications and risks. Curr Infect Dis Rep 6: 34–42.
Barrett AD, Monath TP, Barban V, Niedrig M, Teuwen DE, 2007. 17D yellow fever vaccines: new insights. A report of a workshop held during the World Congress on medicine and health in the tropics, Marseille, France, Monday 12 September 2005. Vaccine 25: 2758–2765.
Staples JE, Gershman M, Fischer M; Centers for Disease Control and Prevention, 2010. Yellow fever vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 59: 1–27.
Wilder-Smith A, Hill DR, Freedman DO, 2008. The revised International Health Regulations (2005): impact on yellow fever vaccination in clinical practice. Am J Trop Med Hyg 78: 359–360.
Reinhardt B, Jaspert R, Niedrig M, Kostner C, L'Age-Stehr J, 1998. Development of viremia and humoral and cellular parameters of immune activation after vaccination with yellow fever virus strain 17D: a model of human flavivirus infection. J Med Virol 56: 159–167.
Gomez SY, Ocazionez RE, 2008. Yellow fever virus 17D neutralizing antibodies in vaccinated Colombian people and unvaccinated ones having immunity against dengue [in Spanish]. Rev Salud Publica (Bogota) 10: 796–807.
Groot H, Riberiro RB, 1962. Neutralizing and haemagglutination-inhibiting antibodies to yellow fever 17 year(s) after vaccination with 17D vaccine. Bull World Health Organ 27: 699–707.
Poland JD, Calisher CH, Monath TP, Downs WG, Murphy K, 1981. Persistence of neutralizing antibody 30–35 year(s) after immunization with 17D yellow fever vaccine. Bull World Health Organ 59: 895–900.
de Melo AB, da Silva M da P, Magalhaes MC, Gonzales Gil LH, Freese de Carvalho EM, Braga-Neto UM, Bertani GR, Marques ET Jr, Cordeiro MT, 2011. Description of a prospective 17DD yellow fever vaccine cohort in Recife, Brazil. Am J Trop Med Hyg 85: 739–747.
Rosenzweig EC, Babione RW, Wisseman CL Jr, 1963. Immunological studies with group B arthropod-borne viruses. IV. Persistence of yellow fever antibodies following vaccination with 17D strain yellow fever vaccine. Am J Trop Med Hyg 12: 230–235.
Niedrig M, Lademann M, Emmerich P, Lafrenz M, 1999. Assessment of IgG antibodies against yellow fever virus after vaccination with 17D by different assays: neutralization test, haemagglutination inhibition test, immunofluorescence assay and ELISA. Trop Med Int Health 4: 867–871.
Coulange Bodilis H, Benabdelmoumen G, Gergely A, Goujon C, Pelicot M, Poujol P, Consigny PH, 2011. Long term persistence of yellow fever neutralizing antibodies in elderly persons [in French]. Bull Soc Pathol Exot 104: 260–265.
Centers for Disease Control and Prevention, 2010. Transmission of yellow fever vaccine virus through breast-feeding–Brazil, 2009. MMWR Morb Mortal Wkly Rep 59: 130–132.
Kuhn S, Twele-Montecinos L, MacDonald J, Webster P, Law B, 2011. Case report: probable transmission of vaccine strain of yellow fever virus to an infant via breast milk. CMAJ 183: E243–E245.
Anonymous, 2011. Meeting of the Global Advisory Committee on Vaccine Safety, December 2010. Wkly Epidemiol Rec 86: 38–43.
Kengsakul K, Sathirapongsasuti K, Punyagupta S, 2002. Fatal myeloencephalitis following yellow fever vaccination in a case with HIV infection. J Med Assoc Thai 85: 131–134.
Mason RA, Tauraso NM, Ginn RK, O'Brien TC, Trimmer RW, 1972. Yellow fever vaccine. V. Antibody response in maonkeys inoculated with graded doses of the 17D vaccine. Appl Microbiol 23: 908–913.
Mason RA, Tauraso NM, Spertzel RO, Ginn RK, 1973. Yellow fever vaccine: direct challenge of monkeys given graded doses of 17D vaccine. Appl Microbiol 25: 539–544.
Staples JE, Gershman M, Fischer M; Centers for Disease Control and Prevention, 2010. Yellow fever vaccine: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 59: 1–27.
Julander JG, Trent DW, Monath TP, 2011. Immune correlates of protection against yellow fever determined by passive immunization and challenge in the hamster model. Vaccine 29: 6008–6016.
Hombach J, Solomon T, Kurane I, Jacobson J, Wood D, 2005. Report on a WHO consultation on immunological endpoints for evaluation of new Japanese encephalitis vaccines, WHO, Geneva, 2–3 September, 2004. Vaccine 23: 5205–5211.
Monath TP, 2005. Yellow fever vaccine. Expert Rev Vaccines 4: 553–574.
Hepburn MJ, Kortepeter MG, Pittman PR, Boudreau EF, Mangiafico JA, Buck PA, Norris SL, Anderson EL, 2006. Neutralizing antibody response to booster vaccination with the 17d yellow fever vaccine. Vaccine 24: 2843–2849.
Groot H, Gast-Galvis A, 1965. Observations on the 17 D virus vaccine against yellow fever, applied by cutaneous scarification [in Spanish]. Rev Invest (Guadalajara) 5: 5–25.
Guerra HL, Sardinha TM, da Rosa AP, Lima e Costa MF, 1997. Effectiveness of the yellow fever vaccine 17D: an epidemiologic evaluation in health services [in Spanish]. Rev Panam Salud Publica 2: 115–120.
Vazquez S, Valdes O, Pupo M, Delgado I, Alvarez M, Pelegrino JL, Guzmán MG, 2003. MAC-ELISA and ELISA inhibition methods for detection of antibodies after yellow fever vaccination. J Virol Methods 110: 179–184.
Camacho LA, Freire M da S, Leal M da L, Aguiar SG, Nascimento JP, Iguchi T, Lozana J de A, Farias RH; Collaborative Group for the Study of Yellow Fever Vaccines, 2004. Immunogenicity of WHO-17D and Brazilian 17DD yellow fever vaccines: a randomized trial. Rev Saude Publica 38: 671–678.
Tavares-Neto J, Freitas-Carvalho J, Nunes MR, Rocha G, Rodrigues SG, Damasceno E, Darub R, Viana S, Vasconcelos PF, 2004. Serologic survey for yellow fever and other arboviruses among inhabitants of Rio Branco, Brazil, before and three months after receiving the yellow fever 17D vaccine [in Portuguese]. Rev Soc Bras Med Trop 37: 1–6.
Belmusto-Worn VE, Sanchez JL, McCarthy K, Nichols R, Bautista CT, Magill AJ, Pastor-Cauna G, Echevarria C, Laguna-Torres VA, Samame BK, Baldeon ME, Burnas JP, Olson JG, Bedford P, Kitchener S, Monath TP, 2005. Randomized, double-blind, phase III, pivotal field trial of the comparative immunogenicity, safety, and tolerability of two yellow fever 17D vaccines (Arilvax and YF-VAX) in healthy infants and children in Peru. Am J Trop Med Hyg 72: 189–197.
Pfister M, Kursteiner O, Hilfiker H, Favre D, Durrer P, Ennaji A, L'Age-Stehr J, Kaufhold A, Herzog C, 2005. Immunogenicity and safety of BERNA-YF compared with two other 17D yellow fever vaccines in a phase 3 clinical trial. Am J Trop Med Hyg 72: 339–346.
Suzano CE, Amaral E, Sato HK, Papaiordanou PM; Campinas Group on Yellow Fever Immunization during Pregnancy, 2006. The effects of yellow fever immunization (17DD) inadvertently used in early pregnancy during a mass campaign in Brazil. Vaccine 24: 1421–1426.
Monath TP, Nichols R, Archambault WT, Moore L, Marchesani R, Tian J, Shope RE, Thomas N, Schrader R, Furby D, Bedford P, 2002. Comparative safety and immunogenicity of two yellow fever 17D vaccines (ARILVAX and YF-VAX) in a phase III multicenter, double-blind clinical trial. Am J Trop Med Hyg 66: 533–541.
Monath TP, 2001. Yellow fever: an update. Lancet Infect Dis 1: 11–20.
Niedrig M, Kursteiner O, Herzog C, Sonnenberg K, 2008. Evaluation of an indirect immunofluorescence assay for detection of immunoglobulin M (IgM) and IgG antibodies against yellow fever virus. Clin Vaccine Immunol 15: 177–181.
Wisseman CL Jr, Sweet BH, 1962. Immunological studies with group B arthropod-borne viruses. III. Response of human subjects to revaccination with 17D strain yellow fever vaccine. Am J Trop Med Hyg 11: 570–575.
Omilabu SA, Adejumo JO, Olaleye OD, Fagbami AH, Baba SS, 1990. Yellow fever haemagglutination-inhibiting, neutralising and IgM antibodies in vaccinated and unvaccinated residents of Ibadan, Nigeria. Comp Immunol Microbiol Infect Dis 13: 95–100.
Munoz-Jordan JL, Laurent-Rolle M, Ashour J, Martinez-Sobrido L, Ashok M, Lipkin WI, García-Sastre A, 2005. Inhibition of alpha/beta interferon signaling by the NS4B protein of flaviviruses. J Virol 79: 8004–8013.
Bonnevie-Nielsen V, Heron I, Monath TP, Calisher CH, 1995. Lymphocytic 2′,5′-oligoadenylate synthetase activity increases prior to the appearance of NTAbs and immunoglobulin M and immunoglobulin G antibodies after primary and secondary immunization with yellow fever vaccine. Clin Diagn Lab Immunol 2: 302–306.
Bruyand M, Receveur MC, Pistone T, Verdiere CH, Thiebaut R, Malvy D, 2008. Yellow fever vaccination in non-immunocompetent patients [in French]. Med Mal Infect 38: 524–532.
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