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Towards a Casa Segura: A Consumer Product Study of the Effect of Insecticide-Treated Curtains on Aedes aegypti and Dengue Virus Infections in the Home

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  • Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico; Servicios de Salud de Yucatán, Mérida, Yucatán, Mexico; Bayer de México S.A. de C.V., Bayer Environmental Science, México City, Mexico; Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology, and Pathology, and Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, Colorado

The home, or domicile, is the principal environment for transmission of dengue virus (DENV) between humans and mosquito vectors. Community-wide distribution of insecticide-treated curtains (ITCs), mimicking vector control program-driven interventions, has shown promise to reduce DENV infections. We conducted a Casa Segura consumer product intervention study in Mérida, Mexico to determine the potential to reduce intradomicillary DENV transmission through ITC use in individual homes. Dengue virus infections in mosquitoes and in humans were reduced in homes with ITCs in one of two study subareas. Overall, ITCs reduced intradomicillary DENV transmission; ITC homes were significantly less likely to experience multiple DENV infections in humans than NTC homes. Dengue virus–infected Aedes aegypti females were reduced within the ITC homes where curtain use was highest. Some homes yielded up to nine infected Ae. aegypti females. This study provides insights regarding best practices for Casa Segura interventions to protect homes from intradomicillary DENV transmission.

Author Notes

* Address correspondence to Barry J. Beaty, Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO 80523. E-mail: barry.beaty@colostate.edu

Financial support: The study was supported by the Innovative Vector Control Consortium and by the National Institutes of Health/National Institute of Allergy and Infectious Diseases (International Collaborations in Infectious Disease Research Program U01-AI-088647).

Disclosure: Some of the authors are employed by Bayer de México, one of the providers of the insecticide-treated curtains used in the study.

Authors' addresses: María Alba Loroño-Pino, Julián E. García-Rejón, and Carlos Machain-Williams, Laboratorio de Arbovirología, Centro de Investigaciones Regionales Dr. Hideyo Noguchi, Universidad Autónoma de Yucatán, Mérida, Yucatán, Mexico, E-mails: maria.lorono@gmail.com, grejon@uady.mx, and carlos.machain@uady.mx. Salvador Gomez-Carro, Guadalupe Nuñez-Ayala, and Maria del Rosario Nájera-Vázquez, Servicios de Salud de Yucatán, Mérida, Yucatán, Mexico, E-mails: salvador.gomez@ssy.gob.mx, guadalupe.nunez@ssy.gob.mx, and dengue.yucatan@ssy.gob.mx. Arturo Losoya and Lyla Aguilar, Bayer de México S.A. de C.V., Bayer Environmental Science, México City, Mexico, E-mails: arturo.losoya@bayer.com and lyla.aguilar@bayer.com. Karla Saavedra-Rodriguez, Saul Lozano-Fuentes, Meaghan K. Beaty, William C. Black IV, Lars Eisen, and Barry J. Beaty, Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology, and Pathology, Colorado State University, Fort Collins, CO, E-mails: karla.saavedra_rodriguez@colostate.edu, slozano@colostate.edu, meaghanb8y@gmail.com, william.black@colostate.edu, lars.eisen@colostate.edu, and barry.beaty@colostate.edu. Thomas J. Keefe, Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, E-mail: thomas.keefe@colostate.edu.

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