Comparison of Clinical and Laboratory Characteristics of Intestinal Amebiasis with Shigellosis among Patients Visiting a Large Urban Diarrheal Disease Hospital in Bangladesh

Sumon Kumar Das International Centre for Diarrheal Disease Research, Bangladesh (icddr,b)

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Mohammod Jobayer Chisti International Centre for Diarrheal Disease Research, Bangladesh (icddr,b)

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Mohammad Abdul Malek International Centre for Diarrheal Disease Research, Bangladesh (icddr,b)

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Mohammed Abdus Salam International Centre for Diarrheal Disease Research, Bangladesh (icddr,b)

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Tahmeed Ahmed International Centre for Diarrheal Disease Research, Bangladesh (icddr,b)

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Abu Syed Golam Faruque International Centre for Diarrheal Disease Research, Bangladesh (icddr,b)

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Dinesh Mondal International Centre for Diarrheal Disease Research, Bangladesh (icddr,b)

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Between 1993 and 2011, a total of 371 intestinal amebiasis (IA), caused by Entamoeba histolytica cases were compared with 1,113 shigellosis (randomly selected) patients of icddr,b, excluding co-infections (rotavirus and Vibrio cholerae) in two age stratums: 0–14 years of age and ≥ 15 years of age. The number of IA and shigellosis cases gradually reduced over the study period. In multivariate analysis, individuals 0–14 years of age, slum dwellers (odds ratio [OR] 3.51; 95% confidence interval [CI] 1.69–7.24; P < 0.001), red blood cell (0.44 [0.24–0.86] 0.016), fecal leukocytes (0.17 [0.07–0.33] < 0.001), and alkaline stool (0.16 [0.07–0.36] < 0.001) were independently associated with IA; and among individuals ≥ 15 years of age, living in the slum area (1.88 [1.12–3.14] 0.016), watery stool (2.21 [1.37–3.55] 0.001), use of antimicrobials before visiting hospital (0.67 [0.46–0.99] 0.047), red blood cell (0.45 [0.22–0.94] 0.036), and fecal leukocytes (0.21 [0.12–0.35] < 0.001) in stool were independently associated with IA. Socio-demographic and clinical characteristics of IA and shigellosis varied distantly from each other.

Author Notes

* Address correspondence to Abu Syed Golam Faruque, Center for Nutrition and Food Security (CNFS), International Centre for Diarrheal Disease Research, Bangladesh (icddr,b), 68 Shaheed Tajuddin Ahmed Sarani Mohakhali, Dhaka 1212, Bangladesh. E-mail: gfaruque@icddrb.org

Financial support: Hospital surveillance was funded by icddr,b and the Government of the People's Republic of Bangladesh through IHP-HNPRP. icddr,b acknowledges with gratitude the commitment of the Government of the People's Republic of Bangladesh to the icddr,b's research efforts. icddr,b also gratefully acknowledges the following donors that provide unrestricted support to the Centre's research efforts: Australian Agency for International Development (AusAID), Government of the People's Republic of Bangladesh, Canadian International Development Agency (CIDA), Embassy of the Kingdom of the Netherlands (EKN), Swedish International Development Cooperation Agency (Sida), Swiss Agency for Development and Cooperation (SDC), and Department for International Development, UK (DFID).

Authors' addresses: Sumon Kumar Das, Mohammod Jobayer Chisti, Mohammad Abdul Malek, Mohammed Abdus Salam, Tahmeed Ahmed, Abu Syed Golam Faruque, and Dinesh Mondal, International Centre for Diarrheal Disease Research, Bangladesh (icddr,b), E-mails: sumon@icddrb.org, chisti@icddrb.org, mamalek@icddrb.org, masalm@icddrb.org, tahmeed@icddrb.org, gfaruque@icddrb.org, and din63d@icddrb.org.

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