Authors:
, , , , , , , , , , , , , , , , , and
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Elias PM, Fritsch PO, 1989. Erythema multiforme. Fitzpatrick TB, Eisen AZ, Wolff K, editors. Dermatology in General Medicine. New York: McGraw-Hill, 555– 562.
-
2.
Department of HIV and AIDS Ministry of Health, 2012. Quarterly Report of the Antiretroviral Treatment Programme in Malawi with Results up to July 31, 2012. Lilongwe, Malawi: Malawi Ministry of Health, Department of HIV and AIDS.
-
3.
Kiertiburanakul S, Sungkanuparph S, Charoenyingwattana A, Mahasirimongkol S, Sura T, Chantratita W, 2008. Risk factors for nevirapine-associated rash among HIV-infected patients with low CD4 cell counts in resource-limited settings. Curr HIV Res 6: 65– 69.
-
4.
Stevens AM, Johnson FC, 1922. A new eruptive fever associated with stomatitis and ophthalmia. Report of two cases in children. Am J Dis Child 24: 526.
-
5.
Mondino BJ, 1990. Cicatricial pemphigoid and erythema multiforme. Ophthalmology 97: 939– 952.
-
6.
Saka B, Kombaté K, Mouhari-Toure A, Akakpo S, Tchangaï-Walla K, Pitché P, 2010. Stevens-Johnson syndrome and toxic epidermal necrolysis in a teaching hospital in Lomé, Togo: retrospective study of 89 cases. Med Trop 70: 255– 258.
-
7.
Ukponmwan CU, Njinaka I, Ehimiyen ET, 2010. Ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis. Trop Doct 40: 167– 168.
-
8.
Roujeau JC, Guillaume JC, Fabre JP, Penso D, Fléchet ML, Girre JP, 1990. Toxic epidermal necrolysis (Lyell syndrome): incidence and drug etiology in France, 1981–1985. Arch Dermatol 126: 37– 42.
-
9.
Roujeau JC, Kelly JP, Naldi L, Rzany B, Stern RS, Anderson T, Auquier A, Bastuji-Garin S, Correia O, Locati F, 1995. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med 333: 1600– 1607.
-
10.
Gimnig JE, MacArthur JR, M'ang'mbe M, Kramer MH, Chizani N, Stern RS, Mkandala C, Newman RD, Steketee RW, Campbell CH, 2006. Severe cutaneous reactions to sulfadoxine-pyrimethamine and trimethoprim-sulfamethoxazole in Blantyre District, Malawi. Am J Trop Med Hyg 74: 738– 743.
-
11.
Di Pascuale MA, Espana EM, Liu DT, Kawakita T, Li W, Gao YY, Baradaran-Rafii A, Elizondo A, Raju VK, Tseng SC, 2005. Correlation of corneal complications with eyelid cicatricial pathologies in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis syndrome. Ophthalmology 112: 904– 912.
-
12.
Gregory DG, 2011. Treatment of acute SJS and TEN using amniotic membrane: a review of 10 consecutive cases. Ophthalmology 118: 908– 914.
-
13.
Shammas MC, Lai EC, Sarkar JS, Yang J, Starr CE, Sippel KC, 2010. Management of acute Stevens-Johnson syndrome and toxic epidermal necrolysis utilizing amniotic membrane and topical corticosteroids. Am J Ophthalmol 149: 203– 213.
-
14.
Araki Y, Sotozono T, Ueta M, Yokoi N, Ueda E, Kishimoto S, Kinoshita S, 2009. Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset. Am J Ophthalmol 147: 1004– 1011.
-
15.
Satake Y, Higa K, Tsubota K, Shimazaki J, 2011. Long-term outcome of cultivated oral mucosal epithelial sheet transplantation in treatment of total limbal stem cell deficiency. Ophthalmology 118: 1524– 1530.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 407 | 355 | 114 |
| Full Text Views | 323 | 16 | 0 |
| PDF Downloads | 77 | 14 | 0 |
Severe Eye Complications from Stevens-Johnson Syndrome in a Human Immunodeficiency Virus–Infected Patient in Malawi
Markus Schulze Schwering
Markus Schulze Schwering
Department of Ophthalmology, and Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi; Lions Sight First Eye Hospital, Blantyre, Malawi; University Eye Hospital, Tübingen, Germany
Search for other papers by Markus Schulze Schwering in
Current site
Google Scholar
PubMed
Search for other papers by Markus Schulze Schwering in
Current site
Google Scholar
PubMed
Petros Kayange
Petros Kayange
Department of Ophthalmology, and Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi; Lions Sight First Eye Hospital, Blantyre, Malawi; University Eye Hospital, Tübingen, Germany
Search for other papers by Petros Kayange in
Current site
Google Scholar
PubMed
Search for other papers by Petros Kayange in
Current site
Google Scholar
PubMed
Joep J. van Oosterhout
Joep J. van Oosterhout
Department of Ophthalmology, and Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi; Lions Sight First Eye Hospital, Blantyre, Malawi; University Eye Hospital, Tübingen, Germany
Search for other papers by Joep J. van Oosterhout in
Current site
Google Scholar
PubMed
Search for other papers by Joep J. van Oosterhout in
Current site
Google Scholar
PubMed
Martin S. Spitzer
Martin S. Spitzer
Department of Ophthalmology, and Department of Medicine, College of Medicine, University of Malawi, Blantyre, Malawi; Lions Sight First Eye Hospital, Blantyre, Malawi; University Eye Hospital, Tübingen, Germany
Search for other papers by Martin S. Spitzer in
Current site
Google Scholar
PubMed
Search for other papers by Martin S. Spitzer in
Current site
Google Scholar
PubMed
Stevens-Johnson syndrome (SJS) is a severe form of erythema multiforme that primarily affects skin and mucous membranes. In Malawi, manifestations of SJS may become more common in human immunodeficiency virus–infected patients receiving nevirapine-based antiretroviral therapy (ART) because the CD4 cell threshold for starting ART has increased from 250 to 350 cells/μL. We describe a patient with severe ocular complications from SJS that developed soon after initiation of nevirapine-based ART and cotrimoxazole preventive treatment, which led to blindness. We draw attention to preventive measures that can potentially reduce permanent ocular damage from SJS.
Author Notes
Authors' addresses: Markus Schulze Schwering and Petros Kayange, Department of Ophthalmology, College of Medicine, University of Malawi, Blantyre, Malawi, E-mails: mssoculus@web.de and petroskayange@yahoo.com. Joep van Oosterhout, Department of Medicine, College of Medicine, University of Malawi, PO Bag 360, Blantyre 3, Malawi, E-mail: joepvanoosterhout@gmail.com. Martin Spitzer, Department of Ophthalmology, University Eye Hospital, Tübingen, Germany, E-mail: spitzko@googlemail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Elias PM, Fritsch PO, 1989. Erythema multiforme. Fitzpatrick TB, Eisen AZ, Wolff K, editors. Dermatology in General Medicine. New York: McGraw-Hill, 555– 562.
-
2.
Department of HIV and AIDS Ministry of Health, 2012. Quarterly Report of the Antiretroviral Treatment Programme in Malawi with Results up to July 31, 2012. Lilongwe, Malawi: Malawi Ministry of Health, Department of HIV and AIDS.
-
3.
Kiertiburanakul S, Sungkanuparph S, Charoenyingwattana A, Mahasirimongkol S, Sura T, Chantratita W, 2008. Risk factors for nevirapine-associated rash among HIV-infected patients with low CD4 cell counts in resource-limited settings. Curr HIV Res 6: 65– 69.
-
4.
Stevens AM, Johnson FC, 1922. A new eruptive fever associated with stomatitis and ophthalmia. Report of two cases in children. Am J Dis Child 24: 526.
-
5.
Mondino BJ, 1990. Cicatricial pemphigoid and erythema multiforme. Ophthalmology 97: 939– 952.
-
6.
Saka B, Kombaté K, Mouhari-Toure A, Akakpo S, Tchangaï-Walla K, Pitché P, 2010. Stevens-Johnson syndrome and toxic epidermal necrolysis in a teaching hospital in Lomé, Togo: retrospective study of 89 cases. Med Trop 70: 255– 258.
-
7.
Ukponmwan CU, Njinaka I, Ehimiyen ET, 2010. Ocular complications of Stevens-Johnson syndrome and toxic epidermal necrolysis. Trop Doct 40: 167– 168.
-
8.
Roujeau JC, Guillaume JC, Fabre JP, Penso D, Fléchet ML, Girre JP, 1990. Toxic epidermal necrolysis (Lyell syndrome): incidence and drug etiology in France, 1981–1985. Arch Dermatol 126: 37– 42.
-
9.
Roujeau JC, Kelly JP, Naldi L, Rzany B, Stern RS, Anderson T, Auquier A, Bastuji-Garin S, Correia O, Locati F, 1995. Medication use and the risk of Stevens-Johnson syndrome or toxic epidermal necrolysis. N Engl J Med 333: 1600– 1607.
-
10.
Gimnig JE, MacArthur JR, M'ang'mbe M, Kramer MH, Chizani N, Stern RS, Mkandala C, Newman RD, Steketee RW, Campbell CH, 2006. Severe cutaneous reactions to sulfadoxine-pyrimethamine and trimethoprim-sulfamethoxazole in Blantyre District, Malawi. Am J Trop Med Hyg 74: 738– 743.
-
11.
Di Pascuale MA, Espana EM, Liu DT, Kawakita T, Li W, Gao YY, Baradaran-Rafii A, Elizondo A, Raju VK, Tseng SC, 2005. Correlation of corneal complications with eyelid cicatricial pathologies in patients with Stevens-Johnson syndrome and toxic epidermal necrolysis syndrome. Ophthalmology 112: 904– 912.
-
12.
Gregory DG, 2011. Treatment of acute SJS and TEN using amniotic membrane: a review of 10 consecutive cases. Ophthalmology 118: 908– 914.
-
13.
Shammas MC, Lai EC, Sarkar JS, Yang J, Starr CE, Sippel KC, 2010. Management of acute Stevens-Johnson syndrome and toxic epidermal necrolysis utilizing amniotic membrane and topical corticosteroids. Am J Ophthalmol 149: 203– 213.
-
14.
Araki Y, Sotozono T, Ueta M, Yokoi N, Ueda E, Kishimoto S, Kinoshita S, 2009. Successful treatment of Stevens-Johnson syndrome with steroid pulse therapy at disease onset. Am J Ophthalmol 147: 1004– 1011.
-
15.
Satake Y, Higa K, Tsubota K, Shimazaki J, 2011. Long-term outcome of cultivated oral mucosal epithelial sheet transplantation in treatment of total limbal stem cell deficiency. Ophthalmology 118: 1524– 1530.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 407 | 355 | 114 |
| Full Text Views | 323 | 16 | 0 |
| PDF Downloads | 77 | 14 | 0 |