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1.
Woods WJ, Belone A de F, Carneiro LB, Rosa PS, 2010. Ten years experience with Jorge Lobo's disease in the state of Acre, Amazon region, Brazil. Rev Inst Med Trop Sao Paulo 52: 273–278.
-
2.
Rodríguez-Toro G, Tellez N, 1992. Lobomycosis in Colombian Amerindian patients. Mycopathologia 120: 5–9.
-
3.
Romero RO, 1972. Jorge Lobo's disease (keloyd blastomycosis). Diagnosis of the first Peruvian case. Arch Per Pat Clin 26: 63–86.
-
4.
Talhari S, Caparo AB, Ganter B, 1985. Jorge Lobo's disease. Second Peruvian case. Med Cut ILA 13: 201–204.
-
5.
Machado P de A, 1972. Spontaneous regression of macular lesions in Jorge Lobo's blastomycosis. Acta Amaz (Manaus) 2: 47–50.
-
6.
Lawrence D, Ajello L, 1986. Lobomycosis in western Brazil: report of a clinical trial with ketoconazole. Am J Trop Med Hyg 35: 162–166.
-
7.
Carneiro FP, Maia LB, Moraes MA, de Magalhães AV, Vianna LM, Zancanaro PC, Reis CM, 2009. Lobomycosis: diagnosis and management of relapsed and multifocal lesions. Diagn Microbiol Infect Dis 65: 62–64.
-
8.
Fischer M, Chrusciak Talhari A, Reinel D, Talhari S, 2002. Sucessful treatment with clofazimine and itraconazole in a 46-year-old patient after 32 years duration of disease. Hautarzt 53: 677–681.
-
9.
Miranda MF, Unger DA, Brito AC, Carneiro FA, 2011. Jorge Lobo's disease with restricted labial presentation. An Bras Dermatol 86: 373–374.
-
10.
Baruzzi RG, Marcopito LF, Michalany NS, Livianu J, Pinto NR, 1981. Early diagnosis and prompt treatment by surgery in Jorge Lobo's disease (keloidal lastomycosis). Mycopathologia 74: 51–54.
-
11.
Negroni R, Tobon A, Bustamante B, Shikanai-Yasuda MA, Patino H, Restrepo A, 2005. Posaconazole treatment of refractory eumycetoma and chromoblastomycosis. Rev Inst Med Trop Sao Paulo 47: 339–346.
-
12.
Raad II, Graybill JR, Bustamante AB, Cornely OA, Gaona-Flores V, Afif C, Graham DR, Greenberg RN, Hadley S, Langston A, Negroni R, Perfect JR, Pitisuttithum P, Restrepo A, Schiller G, Pedicone L, Ullmann AJ, 2006. Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections. Clin Infect Dis 42: 1726–1734.
-
13.
Vilani-Moreno FR, Belone A de F, Rosa PS, Madeira S, Opromolla DV, 2003. Evaluation of the vital staining method for Lacazia loboi through the experimental inoculation of BALB/c mice. Med Mycol 41: 211–216.
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Lobomycosis Successfully Treated with Posaconazole
Beatriz Bustamante
Beatriz Bustamante
Departamento de Enfermedades Infecciosas, Tropicales y Dermatológicas, Hospital Nacional Cayetano Heredia, Lima, Peru; Instituto de Medicina Tropical Alexander von Humbold, Universidad Peruana Cayetano Heredia, Lima, Peru
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Carlos Seas
Carlos Seas
Departamento de Enfermedades Infecciosas, Tropicales y Dermatológicas, Hospital Nacional Cayetano Heredia, Lima, Peru; Instituto de Medicina Tropical Alexander von Humbold, Universidad Peruana Cayetano Heredia, Lima, Peru
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Martín Salomon
Martín Salomon
Departamento de Enfermedades Infecciosas, Tropicales y Dermatológicas, Hospital Nacional Cayetano Heredia, Lima, Peru; Instituto de Medicina Tropical Alexander von Humbold, Universidad Peruana Cayetano Heredia, Lima, Peru
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Francisco Bravo
Francisco Bravo
Departamento de Enfermedades Infecciosas, Tropicales y Dermatológicas, Hospital Nacional Cayetano Heredia, Lima, Peru; Instituto de Medicina Tropical Alexander von Humbold, Universidad Peruana Cayetano Heredia, Lima, Peru
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Lobomycosis is a chronic subcutaneous mycosis for which no standard treatment is available to date. We describe a patient in Peru with lobomycosis on the left earlobe that was successfully treated with posaconazole for 27 months. No evidence of recurrence was observed after five years of follow-up.
Author Notes
Financial support: Beatriz Bustamante participated as study investigator in a clinical trial sponsored by Schering Plough for which the patient was enrolled. Carlos Seas was supported by an Investigator Initiated Research grant from Pfizer.
Authors' addresses: Beatriz Bustamante and Carlos Seas, Departamento de Enfermedades Infecciosas, Tropicales y Dermatológicas, Hospital Nacional Cayetano Heredia, Lima, Peru, and Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mails: ana.bustamante@upch.pe and carlos.seas@upch.pe. Martín Salomon, Departamento de Enfermedades Infecciosas, Tropicales y Dermatológicas, Hospital Nacional Cayetano Heredia, Lima, Peru, E-mail: martin.salomon.n@upch.pe. Francisco Bravo, Instituto de Medicina Tropical Alexander von Humboldt, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: fbravopuccio@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Woods WJ, Belone A de F, Carneiro LB, Rosa PS, 2010. Ten years experience with Jorge Lobo's disease in the state of Acre, Amazon region, Brazil. Rev Inst Med Trop Sao Paulo 52: 273–278.
-
2.
Rodríguez-Toro G, Tellez N, 1992. Lobomycosis in Colombian Amerindian patients. Mycopathologia 120: 5–9.
-
3.
Romero RO, 1972. Jorge Lobo's disease (keloyd blastomycosis). Diagnosis of the first Peruvian case. Arch Per Pat Clin 26: 63–86.
-
4.
Talhari S, Caparo AB, Ganter B, 1985. Jorge Lobo's disease. Second Peruvian case. Med Cut ILA 13: 201–204.
-
5.
Machado P de A, 1972. Spontaneous regression of macular lesions in Jorge Lobo's blastomycosis. Acta Amaz (Manaus) 2: 47–50.
-
6.
Lawrence D, Ajello L, 1986. Lobomycosis in western Brazil: report of a clinical trial with ketoconazole. Am J Trop Med Hyg 35: 162–166.
-
7.
Carneiro FP, Maia LB, Moraes MA, de Magalhães AV, Vianna LM, Zancanaro PC, Reis CM, 2009. Lobomycosis: diagnosis and management of relapsed and multifocal lesions. Diagn Microbiol Infect Dis 65: 62–64.
-
8.
Fischer M, Chrusciak Talhari A, Reinel D, Talhari S, 2002. Sucessful treatment with clofazimine and itraconazole in a 46-year-old patient after 32 years duration of disease. Hautarzt 53: 677–681.
-
9.
Miranda MF, Unger DA, Brito AC, Carneiro FA, 2011. Jorge Lobo's disease with restricted labial presentation. An Bras Dermatol 86: 373–374.
-
10.
Baruzzi RG, Marcopito LF, Michalany NS, Livianu J, Pinto NR, 1981. Early diagnosis and prompt treatment by surgery in Jorge Lobo's disease (keloidal lastomycosis). Mycopathologia 74: 51–54.
-
11.
Negroni R, Tobon A, Bustamante B, Shikanai-Yasuda MA, Patino H, Restrepo A, 2005. Posaconazole treatment of refractory eumycetoma and chromoblastomycosis. Rev Inst Med Trop Sao Paulo 47: 339–346.
-
12.
Raad II, Graybill JR, Bustamante AB, Cornely OA, Gaona-Flores V, Afif C, Graham DR, Greenberg RN, Hadley S, Langston A, Negroni R, Perfect JR, Pitisuttithum P, Restrepo A, Schiller G, Pedicone L, Ullmann AJ, 2006. Safety of long-term oral posaconazole use in the treatment of refractory invasive fungal infections. Clin Infect Dis 42: 1726–1734.
-
13.
Vilani-Moreno FR, Belone A de F, Rosa PS, Madeira S, Opromolla DV, 2003. Evaluation of the vital staining method for Lacazia loboi through the experimental inoculation of BALB/c mice. Med Mycol 41: 211–216.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 915 | 845 | 145 |
| Full Text Views | 455 | 8 | 0 |
| PDF Downloads | 143 | 9 | 0 |