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RefWorks
Reference Manager
BibTeX
Zotero
EndNote
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Labadie K, Larcher T, Joubert C, Mannioui A, Delache B, Brochard P, Guigand L, Dubreil L, Lebon P, Verrier B, de Lamballerie X, Suhrbier A, Cherel Y, Le Grand R, Roques P, 2010. Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. J Clin Invest 120: 894–906.
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The Role of Innate versus Adaptive Immune Responses in a Mouse Model of O'Nyong-Nyong Virus Infection
Robert L. Seymour
Robert L. Seymour
Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Shannan L. Rossi
Shannan L. Rossi
Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Nicholas A. Bergren
Nicholas A. Bergren
Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Kenneth S. Plante
Kenneth S. Plante
Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Scott C. Weaver
Scott C. Weaver
Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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O'nyong-nyong virus (ONNV), an alphavirus closely related to chikungunya virus (CHIKV), has caused three major epidemics in Africa since 1959. Both ONNV and CHIKV produce similar syndromes with fever, rash, and debilitating arthralgia. To determine the roles of the innate and adaptive immune responses, we infected different knockout mice with two strains of ONNV (SG650 and MP30). Wild-type, RAG1 KO, and IFNγR KO mice showed no signs of illness or viremia. The STAT1 KO and A129 mice exhibited 50–55% mortality when infected with SG650. Strain SG650 was more virulent in the STAT1 KO and A129 than MP30. Deficiency in interferon α/β signaling (A129 and STAT1 KO) leaves mice susceptible to lethal disease; whereas a deficiency of interferon γ signaling alone had no effect on survival. Our findings highlight the importance of type I interferon in protection against ONNV infection, whereas the adaptive immune system is relatively unimportant in the acute infection.
Author Notes
Financial support: This work was supported by a grant from the National Institute of Allergy and Infectious Disease (NIAID) through the Western Regional Center of Excellence for Biodefense and Emerging Infectious Disease Research, National Institutes of Health (NIH) grant U54 AIO57156, and by NIH grants AI082202 and AI093491. RLS was supported by NIH grant 5T32AI-007536. SLR was supported by NIH grant 5T3AI-007536. KSP was supported by NIH grant 5T327526-12.
Authors' addresses: Robert L. Seymour, Shannan L. Rossi, Nicholas A. Bergren, Kenneth S. Plante, and Scott C. Weaver, Institute for Human Infections and Immunity, Center for Tropical Diseases, and Department of Pathology, University of Texas Medical Branch, Galveston, TX, E-mails: rlseymou@utmb.edu, slrossi@utmb.edu, nabergre@utmb.edu, ksplante@utmb.edu, and sweaver@utmb.edu.
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Reference Manager
BibTeX
Zotero
EndNote
-
1.
Enserink M, 2006. Infectious diseases. Massive outbreak draws fresh attention to little-known virus. Science 311: 1085.
-
2.
Arankalle VA, Shrivastava S, Cherian S, Gunjikar RS, Walimbe AM, Jadhav JM, Sudeep AB, Mishra AC, 2007. Genetic divergence of Chikungunya viruses in India (1963–2006) with special reference to the 2005–2006 explosive epidemic. J Gen Virol 88: 1967–1976.
-
3.
Hapuarachchi HC, Bandara KB, Sumanadasa SD, Hapugoda MD, Lai YL, Lee KS, Tan LK, Lin RT, Ng LF, Bucht G, Abeyewickreme W, Ng LC, 2009. Re-emergence of Chikungunya virus in south-east Asia: virological evidence from Sri Lanka and Singapore. J Gen Virol 91: 1067–1076.
-
4.
Charrel RN, de Lamballerie X, Raoult D, 2007. Chikungunya outbreaks–the globalization of vectorborne diseases. N Engl J Med 356: 769–771.
-
5.
Pialoux G, Gauzere BA, Jaureguiberry S, Strobel M, 2007. Chikungunya, an epidemic arbovirosis. Lancet Infect Dis 7: 319–327.
-
6.
Robin S, Ramful D, Le Seach F, Jaffar-Bandjee MC, Rigou G, Alessandri JL, 2008. Neurologic manifestations of pediatric Chikungunya infection. J Child Neurol 23: 1028–1035.
-
7.
Haddow AJ, Davies CW, Walker AJ, 1960. O'nyong-nyong fever: an epidemic virus disease in East Africa. 1. Introduction. Trans R Soc Trop Med Hyg 54: 517–522.
-
8.
Kiwanuka N, Sanders EJ, Rwaguma EB, Kawamata J, Ssengooba FP, Najjemba R, Were WA, Lamunu M, Bagambisa G, Burkot TR, Dunster L, Lutwama JJ, Martin DA, Cropp CB, Karabatsos N, Lanciotti RS, Tsai TF, Campbell GL, 1999. O'nyong-nyong fever in south-central Uganda, 1996–1997: clinical features and validation of a clinical case definition for surveillance purposes. Clin Infect Dis 29: 1243–1250.
-
9.
Sanders EJ, Rwaguma EB, Kawamata J, Kiwanuka N, Lutwama JJ, Sengooba FP, Lamunu M, Najjemba R, Were WA, Bagambisa G, Campbell GL, 1999. O'nyong-nyong fever in south-central Uganda, 1996–1997: description of the epidemic and results of a household-based seroprevalence survey. J Infect Dis 180: 1436–1443.
-
10.
Lanciotti RS, Ludwig ML, Rwaguma EB, Lutwama JJ, Kram TM, Karabatsos N, Cropp BC, Miller BR, 1998. Emergence of epidemic O'nyong-nyong fever in Uganda after a 35-year absence: genetic characterization of the virus. Virology 252: 258–268.
-
11.
Posey D, O'Rourke T, Roherig JT, Lanciotti RS, Weinberg M, Maloney S, 2005. O'nyong-nyong fever in West Africa. Am J Trop Med Hyg 73: 32.
-
12.
Tesh RB, 1982. Arthritides caused by mosquito-borne viruses. Annu Rev Med 33: 31–40.
-
13.
Williams MC, Woodall JP, Porterfield JS, 1962. O'nyong-nyong fever: an epidemic virus disease in East Africa. V. Human antibody studies by plaque inhibition and other serological tests. Trans R Soc Trop Med Hyg 56: 166–172.
-
14.
Powers AM, Brault AC, Tesh RB, Weaver SC, 2000. Re-emergence of Chikungunya and O'nyong-nyong viruses: evidence for distinct geographical lineages and distant evolutionary relationships. J Gen Virol 81: 471–479.
-
15.
Grandadam M, Caro V, Plumet S, Thiberge JM, Souarès Y, Failloux AB, Tolou HJ, Budelot M, Cosserat D, Leparc-Goffart I, Despres P, 2011. Chikungunya virus, southeastern France. Emerg Infect Dis 17: 910–913.
-
16.
Johnson BK, Gichogo A, Gitau G, Patel N, Ademba G, Kirui R, Highton RB, Smith DH, 1981. Recovery of O'nyong-nyong virus from Anopheles funestus in western Kenya. Trans R Soc Trop Med Hyg 75: 239–241.
-
17.
Williams MC, Woodall JP, Corbert PS, Gillett JD, 1965. O'nyong-nyong fever: an epidemic virus disease in East Africa. 8. Virus isolations from Anopheles mosquitoes. Trans R Soc Trop Med Hyg 59: 300–306.
-
18.
Beaty BJ, Calisher CH, Shope RE, 1989. Arboviruses. Schmidt NJ, Emmons RW, eds. Diagnostic Procedures for Viral, Rickettsial and Chlamydial Infections. Sixth edition. Washington, DC: American Public Health Association, 797–855.
-
19.
Plante K, Wang E, Partidos CD, Weger J, Gorchakov R, Tsetsarkin K, Borland EM, Powers AM, Seymour R, Stinchcomb DT, Osorio JE, Frolov I, Weaver SC, 2011. Novel chikungunya vaccine candidate with an IRES-based attenuation and host range alteration mechanism. PLoS Pathog 7: e1002142.
-
20.
Partidos CD, Weger J, Brewoo J, Seymour R, Borland EM, Ledermann JP, Powers AM, Weaver SC, Stinchcomb DT, Osorio JE, 2011. Probing the attenuation and protective efficacy of a candidate Chikungunya virus vaccine in mice with compromised interferon (IFN) signaling. Vaccine 29: 3067–3073.
-
21.
Smith DR, Carrara AS, Aguilar PV, Weaver SC, 2005. Evaluation of methods to assess transmission potential of Venezuelan equine encephalitis virus by mosquitoes and estimation of mosquito saliva titers. Am J Trop Med Hyg 73: 33–39.
-
22.
Labadie K, Larcher T, Joubert C, Mannioui A, Delache B, Brochard P, Guigand L, Dubreil L, Lebon P, Verrier B, de Lamballerie X, Suhrbier A, Cherel Y, Le Grand R, Roques P, 2010. Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. J Clin Invest 120: 894–906.
-
23.
Herrero LJ, Nelson M, Srikiatkhachorn A, Gu R, Anantapreecha S, Fingerle-Rowson G, Bucala R, Morand E, Santos LL, Mahalingam S, 2011. Critical role for macrophage migration inhibitory factor (MIF) in Ross River virus-induced arthritis and myositis. Proc Natl Acad Sci USA 108: 12048–12053.
-
24.
Rulli NE, Rolph MS, Srikiatkhachorn A, Anantapreecha S, Guglielmotti A, Mahalingam S, 2011. Protection from arthritis and myositis in a mouse model of acute Chikungunya virus disease by bindarit, an inhibitor of monocyte chemotactic protein-1 synthesis. J Infect Dis 204: 1026–1030.
-
25.
Gunn BM, Morrison TE, Whitmore AC, Blevins LK, Hueston L, Fraser RJ, Herrero LJ, Ramirez R, Smith PN, Mahalingam S, Heise MT, 2012. Mannose binding lectin is required for alphavirus-induced arthritis/myositis. PLoS Pathog 8: e1002586.
-
26.
Morrison TE, Simmons JD, Heise MT, 2008. Complement receptor 3 promotes severe Ross River virus-induced disease. J Virol 82: 11263–11272.
-
27.
Morrison TE, Fraser RJ, Smith PN, Mahalingam S, Heise MT, 2007. Complement contributes to inflammatory tissue destruction in a mouse model of Ross River virus-induced disease. J Virol 81: 5132–5143.
-
28.
Couderc T, Chrétien F, Schilte C, Disson O, Brigitte M, Guivel-Benhassine F, Touret Y, Barau G, Cayet N, Schuffnecker I, Depres P, Arenzana-Seisdedos F, Michault A, Albert ML, Lecuit M, 2008. A mouse model for Chikungunya: young age and inefficient type-I interferon signaling are risk factors for severe disease. PLoS Pathog 4: e29.
-
29.
Schilte C, Couderc T, Chretien F, Sourisseau M, Gangneux N, Guivel-Benhassine F, Kraxner A, Tschopp J, Higgs S, Michault A, Arenzana-Seisdedos F, Colonna M, Peduto L, Schwartz O, Lecuit M, Albert ML, 2010. Type I IFN controls Chikungunya virus via its action on nonhematopoietic cells. J Exp Med 207: 429–442.
-
30.
Kelvin AA, Banner D, Silvi G, Moro ML, Spataro N, Gaibani P, Cavrini F, Pierro A, Rossini G, Cameron MJ, Bermejo-Martin JF, Paquette SG, Xu L, Danesh A, Farooqui A, Borghetto I, Kelvin DJ, Sambri V, Rubino S, 2011. Inflammatory cytokine expression is associated with Chikungunya virus resolution and symptom severity. PLoS Negl Trop Dis 5: e1279.
-
31.
Chaaitanya IK, Muruganandam N, Sundaram SG, Kawalekar O, Sugunan AP, Manimunda SP, Ghosal SR, Muthumani K, Vijayachari P, 2011. Role of proinflammatory cytokines and chemokines in chronic arthropathy in CHIKV infection. Viral Immunol 24: 265–271.
-
32.
Chow A, Her Z, Ong EK, Chen JM, Dimatatac F, Kwek DJ, Barkham T, Yang H, Rénia L, Leo YS, Ng LF, 2011. Persistent arthralgia induced by Chikungunya virus infection is associated with interleukin-6 and granulocyte macrophage colony-stimulating factor. J Infect Dis 203: 149–157.
-
33.
Nakaya HI, Gardner J, Poo YS, Major L, Pulendran B, Suhrbier A, 2012. Gene profiling of Chikungunya virus arthritis reveals significant overlap with rheumatoid arthritis. Arthritis Rheum 64: 3553–3563.
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