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-
1.
Navarro JM, Fernández-Roldán C, Pérez-Ruiz M, Sanbonmatsu S, de la Rosa M, Sánchez-Seco MP, 2004. Meningitis by Toscana virus in Spain: description of 17 cases. Med Clin (Barc) 122: 420–422.
-
2.
Sanbonmatsu-Gámez S, Pérez-Ruiz M, Collao X, Sánchez-Seco MP, Morillas-Márquez F, de la Rosa-Fraile M, Navarro-Mari JM, Tenorio A, 2005. Toscana virus in Spain. Emerg Infect Dis 11: 1701–1707.
-
3.
Serata D, Rapinesi C, Del Casale A, Simonetti A, Mazzarini L, Ambrosi E, Kotzalidis GD, Fensore C, Girardi P, Tatarelli R, 2011. Personality changes after Toscana virus (TOSV) encephalitis in a 49-year-old man: a case report. Int J Neurosci 121: 165–169.
-
4.
Bartels S, de Boni L, Kretzschmar HA, Heckmann JG, 2012. Lethal encephalitis caused by the Toscana virus in an elderly patient. J Neurol 259: 175–177.
-
5.
Sanbonmatsu-Gámez S, Pérez-Ruiz M, Palop-Borrás B, Navarro-Marí JM, 2009. Unusual manifestation of Toscana virus infection, Spain. Emerg Infect Dis 15: 347–348.
-
6.
Tappe D, Schmidt-Chanasit J, Günther S, Ries A, 2010. Acute Toscana virus infection mimicked by Yersinia-induced reactive arthritis syndrome after journey to Spain. J Clin Virol 47: 104–105.
-
7.
Dionisio D, Esperti F, Vivarelli A, Valassina M, 2003. Epidemiological, clinical and laboratory aspects of sandfly fever. Curr Opin Infect Dis 16: 383–388.
-
8.
Depaquit J, Grandadam M, Fouque F, Andry PE, Peyrefitte C, 2010. Arthropod-borne viruses transmitted by Phlebotomine sandflies in Europe: a review. Euro Surveill 15: 19507.
-
9.
Collao X, Palacios G, de Ory F, Sanbonmatsu S, Pérez-Ruiz M, Navarro JM, Molina R, Hutchison SK, Lipkin WI, Tenorio A, Sánchez-Seco MP, 2010. Granada virus: a natural phlebovirus reassortant of the sandfly fever Naples serocomplex with low seroprevalence in humans. Am J Trop Med Hyg 83: 760–765.
-
10.
Charrel RN, Moureau G, Temmam S, Izri A, 2009. Massilia virus, a novel Phlebovirus (Bunyaviridae) isolated from sandflies in the Mediterranean. Vector Borne Zoonotic Dis 9: 519–530.
-
11.
Grist NR, Bell EJ, Follett EAC, Urquhart GED, 1979. Neutralization tests. Grist NR, Bell EJ, Follett EAC, Urquhart GED, eds. Diagnostic Methods in Clinical Virology, 3rd Ed. Oxford, UK: Blackwell Scientific Publications, 81–94.
-
12.
Ergünay K, Litzba N, Lo MM, Aydoğan S, Saygan MB, Us D, Weidmann M, Niedrig M, 2011. Performance of various commercial assays for the detection of Toscana virus antibodies. Vector Borne Zoonotic Dis 11: 781–787.
-
13.
Bichaud L, Souris M, Mary C, Ninove L, 2011. Epidemiologic relationship between Toscana virus infection and Leishmania infantum due to common exposure to Phlebotomus perniciosus sandfly vector. PLoS Negl Trop Dis 5: e1328.
-
14.
de Ory-Manchón F, Sanz-Moreno JC, Aranguez-Ruiz E, Ramírez-Fernández R, 2007. Age-dependent seroprevalence of Toscana virus in the Community of Madrid: 1993–1994 and 1999–2000. Enferm Infecc Microbiol Clin 25: 187–189.
-
15.
Nicoletti L, Ciufolini MG, Verani P, 1996. Sandfly fever viruses in Italy. Arch Virol Suppl 11: 41–47.
-
16.
Sánchez-Seco MP, Echevarría JM, Hernández L, Estévez D, Navarro-Marí JM, Tenorio A, 2003. Detection and identification of Toscana and other phleboviruses by RT-nested-PCR assays with degenerated primers. J Med Virol 71: 140–149.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 588 | 508 | 107 |
| Full Text Views | 325 | 11 | 0 |
| PDF Downloads | 96 | 11 | 0 |
Clinic–Epidemiologic Study of Human Infection by Granada Virus, a New Phlebovirus within the Sandfly Fever Naples Serocomplex
José María Navarro-Marí
José María Navarro-Marí
Servicio de Microbiología, Hospital Universitario Virgen de las Nieves, Granada, Spain; Departamento de Microbiología, Facultad de Farmacia, Universidad de Granada, Granada, Spain
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Cristina Gómez-Camarasa
Cristina Gómez-Camarasa
Servicio de Microbiología, Hospital Universitario Virgen de las Nieves, Granada, Spain; Departamento de Microbiología, Facultad de Farmacia, Universidad de Granada, Granada, Spain
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Mercedes Pérez-Ruiz
Mercedes Pérez-Ruiz
Servicio de Microbiología, Hospital Universitario Virgen de las Nieves, Granada, Spain; Departamento de Microbiología, Facultad de Farmacia, Universidad de Granada, Granada, Spain
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Sara Sanbonmatsu-Gámez
Sara Sanbonmatsu-Gámez
Servicio de Microbiología, Hospital Universitario Virgen de las Nieves, Granada, Spain; Departamento de Microbiología, Facultad de Farmacia, Universidad de Granada, Granada, Spain
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Irene Pedrosa-Corral
Irene Pedrosa-Corral
Servicio de Microbiología, Hospital Universitario Virgen de las Nieves, Granada, Spain; Departamento de Microbiología, Facultad de Farmacia, Universidad de Granada, Granada, Spain
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María Jiménez-Valera
María Jiménez-Valera
Servicio de Microbiología, Hospital Universitario Virgen de las Nieves, Granada, Spain; Departamento de Microbiología, Facultad de Farmacia, Universidad de Granada, Granada, Spain
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Granada virus (GRV), a new phlebovirus within the Naples serocomplex, has been recently described in phlebotomine sandflies from Spain. The presence of anti-GRV immunoglobulin G (IgG) antibodies was investigated by indirect fluorescence assay (IFA) and neutralization test (NT) in 920 serum samples from the Granada population. By IFA, an overall GRV seroprevalence of 15.8% (N = 145) was observed, significantly increasing up to 65 years. NT was positive in 18% of anti-GRV IFA-positive samples. IgG antibodies against Toscana virus (TOSV), a hyperendemic phlebovirus within Granada province, were detected in 40% of anti-GRV–positive cases. Anti-GRV IgM antibodies were detected in 36 (6.6%) of 547 acute-phase serum samples from individuals with febrile illness, exanthema, and/or acute respiratory infection. All positives were anti-TOSV IgM-negative. GRV may infect humans, with most cases being asymptomatic. The codetection of anti-GRV and anti-TOSV IgG antibodies could be attributable to cross-reactivity or exposure to the same transmission vector.
Author Notes
Financial support: This study was supported in part by funds from a research project (0328/2009; Junta de Andalucía, Spain).
Authors' addresses: José María Navarro-Marí, Cristina Gómez-Camarasa, Mercedes Pérez-Ruiz, Sara Sanbonmatsu-Gámez, and Irene Pedrosa-Corral, Servicio de Microbiología, Hospital Universitario Virgen de las Nieves, Granada, Spain, E-mails: josem.navarro.sspa@juntadeandalucia.es, gomezcamarasa@hotmail.com, mercedes.perez.ruiz.sspa@juntadeandalucia.es, saral.sanbonmatsu.sspa@juntadeandalucia.es, and irene_pedrosa@msn.com. María Jiménez-Valera, Departamento de Microbiología, Facultad de Farmacia, Universidad de Granada, Granada, Spain, E-mail: mjvalera@ugr.es.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Navarro JM, Fernández-Roldán C, Pérez-Ruiz M, Sanbonmatsu S, de la Rosa M, Sánchez-Seco MP, 2004. Meningitis by Toscana virus in Spain: description of 17 cases. Med Clin (Barc) 122: 420–422.
-
2.
Sanbonmatsu-Gámez S, Pérez-Ruiz M, Collao X, Sánchez-Seco MP, Morillas-Márquez F, de la Rosa-Fraile M, Navarro-Mari JM, Tenorio A, 2005. Toscana virus in Spain. Emerg Infect Dis 11: 1701–1707.
-
3.
Serata D, Rapinesi C, Del Casale A, Simonetti A, Mazzarini L, Ambrosi E, Kotzalidis GD, Fensore C, Girardi P, Tatarelli R, 2011. Personality changes after Toscana virus (TOSV) encephalitis in a 49-year-old man: a case report. Int J Neurosci 121: 165–169.
-
4.
Bartels S, de Boni L, Kretzschmar HA, Heckmann JG, 2012. Lethal encephalitis caused by the Toscana virus in an elderly patient. J Neurol 259: 175–177.
-
5.
Sanbonmatsu-Gámez S, Pérez-Ruiz M, Palop-Borrás B, Navarro-Marí JM, 2009. Unusual manifestation of Toscana virus infection, Spain. Emerg Infect Dis 15: 347–348.
-
6.
Tappe D, Schmidt-Chanasit J, Günther S, Ries A, 2010. Acute Toscana virus infection mimicked by Yersinia-induced reactive arthritis syndrome after journey to Spain. J Clin Virol 47: 104–105.
-
7.
Dionisio D, Esperti F, Vivarelli A, Valassina M, 2003. Epidemiological, clinical and laboratory aspects of sandfly fever. Curr Opin Infect Dis 16: 383–388.
-
8.
Depaquit J, Grandadam M, Fouque F, Andry PE, Peyrefitte C, 2010. Arthropod-borne viruses transmitted by Phlebotomine sandflies in Europe: a review. Euro Surveill 15: 19507.
-
9.
Collao X, Palacios G, de Ory F, Sanbonmatsu S, Pérez-Ruiz M, Navarro JM, Molina R, Hutchison SK, Lipkin WI, Tenorio A, Sánchez-Seco MP, 2010. Granada virus: a natural phlebovirus reassortant of the sandfly fever Naples serocomplex with low seroprevalence in humans. Am J Trop Med Hyg 83: 760–765.
-
10.
Charrel RN, Moureau G, Temmam S, Izri A, 2009. Massilia virus, a novel Phlebovirus (Bunyaviridae) isolated from sandflies in the Mediterranean. Vector Borne Zoonotic Dis 9: 519–530.
-
11.
Grist NR, Bell EJ, Follett EAC, Urquhart GED, 1979. Neutralization tests. Grist NR, Bell EJ, Follett EAC, Urquhart GED, eds. Diagnostic Methods in Clinical Virology, 3rd Ed. Oxford, UK: Blackwell Scientific Publications, 81–94.
-
12.
Ergünay K, Litzba N, Lo MM, Aydoğan S, Saygan MB, Us D, Weidmann M, Niedrig M, 2011. Performance of various commercial assays for the detection of Toscana virus antibodies. Vector Borne Zoonotic Dis 11: 781–787.
-
13.
Bichaud L, Souris M, Mary C, Ninove L, 2011. Epidemiologic relationship between Toscana virus infection and Leishmania infantum due to common exposure to Phlebotomus perniciosus sandfly vector. PLoS Negl Trop Dis 5: e1328.
-
14.
de Ory-Manchón F, Sanz-Moreno JC, Aranguez-Ruiz E, Ramírez-Fernández R, 2007. Age-dependent seroprevalence of Toscana virus in the Community of Madrid: 1993–1994 and 1999–2000. Enferm Infecc Microbiol Clin 25: 187–189.
-
15.
Nicoletti L, Ciufolini MG, Verani P, 1996. Sandfly fever viruses in Italy. Arch Virol Suppl 11: 41–47.
-
16.
Sánchez-Seco MP, Echevarría JM, Hernández L, Estévez D, Navarro-Marí JM, Tenorio A, 2003. Detection and identification of Toscana and other phleboviruses by RT-nested-PCR assays with degenerated primers. J Med Virol 71: 140–149.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 588 | 508 | 107 |
| Full Text Views | 325 | 11 | 0 |
| PDF Downloads | 96 | 11 | 0 |