ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Ministério da Saúde, 2011. Programa Nacional de Controle da Tuberculose. Secretaria de Vigilância em Saúde. Manual de Recomendações para o Controle da Tuberculose no Brasil. Brasil, Ministério da Saúde.
-
2.
Quinn PJ, Carter ME, Markey B, Carter GR, 1994. Clinical Veterinary Microbiology. London: Wolfe, 137–143.
-
3.
Telenti A, Marchesi F, Balz M, Bally F, Botrger EC, Bodmer T, 1993. Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis. J Clin Microbiol 31: 175–178.
-
4.
Parish T, Staker NG, 1998. Mycobacterium protocols. Methods in Molecular Biology, 101. Totowa: Humana Press, 340–341.
-
5.
Acha PN, Szyfres B, 2003. Tuberculose zoonótica. Acha PN, Szyfres B, eds. Zoonosis y Enfermidades Transmisibles Communes al Hombre y a los Animals. Volume I. Washington: Organización Panamericana de la Salud, 266–283.
-
6.
Greene CE, Prescott JF, 2012. Mycobacterial infections. Greene CE, ed. Infectious Diseases of the Dog and Cat. Third edition. St. Louis, MO: Elsevier, 334–335.
-
7.
Parsons SDC, Gous TA, Warren RM, van Helden PD, 2008. Pulmonary Mycobacterium tuberculosis (Beijing strain) infection in a stray dog. J S Afr Vet Assoc 79: 95–98.
-
8.
Ministério da Saúde, 2005. Centro de Referência Professor Hélio Fraga. Manual de Bacteriologia da Tuberculose. Third edition. Brasil: Ministério da Saúde.
-
9.
Prasite, 2007. Identification of Mycobacteria. Available at: Http://app.chuv.ch/prasite/index.html.
-
10.
Chimara E, Ferrazoli L, Leão SC, 2004. Mycobacterium tuberculosis complex differentiation using gyrB restriction fragment length polymorphism analysis. Mem Inst Oswaldo Cruz 99: 745–748.
-
11.
LoBue PA, Enarson DA, Thoen CO, 2010. Tuberculosis in humans and animals: an overview. Int J Tuberc Lung Dis 14: 1075–1078.
-
12.
World Health Organization-WHO, 2011. Global Tuberculosis Control 2011. WHO/HTM/TB/2011. Geneva: WHO.
-
13.
Parsons SD, Warren RM, Ottenhoff TH, Gey van Pittius NC, van Helden PD, 2011. Detection of Mycobacterium tuberculosis infection in dogs in a high-risk setting. Res Vet Sci 92: 414–419.
-
14.
Megid J, Bracarense AP, Reis AC, Sturion DJ, Martin LM, Pinheiro SR, 1994. Tuberculose canina e sua importância em saúde pública. Rev Saude Publica 28: 309–310.
-
15.
Mota PM, Lobato FC, Assis RA, Lage AP, Parreiras PM, 2001. Isolamento de Mycobacterium bovis de cão. Arq Bras Med Vet Zootec 53: 410–412.
-
16.
Horn B, Forshaw D, Cousins D, Irwin PJ, 2000. Disseminated Mycobacterium avium infection in a dog with chronic diarrhea. Aust Vet J 78: 320–325.
-
17.
Bonovska M, Tzvetkov Y, Najdenski H, Bachvarova Y, 2005. PCR for detection of Mycobacterium tuberculosis in experimentally infected dogs. J Vet Med B 52: 165–170.
-
18.
Turinelli V, Ledieu D, Guilbaud L, Marchal T, Magnol JP, Fournel-Fleury C, 2004. Mycobacterium tuberculosis infection in a dog from Africa. Vet Clin Pathol 33: 177–181.
-
19.
Ma YH, Mo ZS, Pan H, Ban W, Hu Y, Yan ST, 1998. Investigation of tuberculosis in army and police dogs in South China. J Vet Sci 28: 12–15.
-
20.
Posthaus H, Bodmer T, Alves L, Oevermann A, Schiller I, Rhodes SG, Zimmerli S, 2011. Accidental infection of veterinary personnel with Mycobacterium tuberculosis at necropsy: a case study. Vet Microbiol 149: 374–380.
-
21.
Fabre M, Koeck J, Le Flèche F, Simon F, Hervé V, Vergnaud G, Pourcel C, 2004. High genetic diversity revealed by variable-number tandem repeat genotyping and analysis of hsp65 gene polymorphism in a large collection of Mycobacterium canetti strains indicates that the M. tuberculosis complex is a recently emerged clone of M. canetti. J Clin Microbiol 42: 3248–3255.
-
22.
De Jong BC, Antonio M, Gagneux S, 2010. Mycobacterium africanum—review of an important cause of human tuberculosis in West Africa. PLoS Negl Trop Dis 4: e744.
-
23.
Erwin PC, Bemis DA, McCombs SB, Sheeler LL, Himelright IM, Halford SK, Diem L, Metchock B, Jones TF, Schilling MG, Thomsen BV, 2004. Mycobacterium tuberculosis transmission from human to canine. Emerg Infect Dis 12: 2258–2260.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 356 | 278 | 22 |
| Full Text Views | 662 | 16 | 1 |
| PDF Downloads | 322 | 14 | 1 |
Disseminated Mycobacterium tuberculosis Infection in a Dog
Anna Paula Vitirito Martinho
Anna Paula Vitirito Martinho
Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP – Univ. Estadual Paulista, Botucatu, State of Sao Paulo, Brazil; Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, State of Sao Paulo, Brazil; Laboratory of Micobacteriology, Faculty of Pharmacy, UNESP, Araraquara, State of Sao Paulo, Brazil; Veterinary Hospital, Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, São Paulo, Brazil
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Marília Masello Junqueira Franco
Marília Masello Junqueira Franco
Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP – Univ. Estadual Paulista, Botucatu, State of Sao Paulo, Brazil; Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, State of Sao Paulo, Brazil; Laboratory of Micobacteriology, Faculty of Pharmacy, UNESP, Araraquara, State of Sao Paulo, Brazil; Veterinary Hospital, Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, São Paulo, Brazil
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Márcio Garcia Ribeiro
Márcio Garcia Ribeiro
Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP – Univ. Estadual Paulista, Botucatu, State of Sao Paulo, Brazil; Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, State of Sao Paulo, Brazil; Laboratory of Micobacteriology, Faculty of Pharmacy, UNESP, Araraquara, State of Sao Paulo, Brazil; Veterinary Hospital, Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, São Paulo, Brazil
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Isabella Belletti Mutt Perrotti
Isabella Belletti Mutt Perrotti
Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP – Univ. Estadual Paulista, Botucatu, State of Sao Paulo, Brazil; Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, State of Sao Paulo, Brazil; Laboratory of Micobacteriology, Faculty of Pharmacy, UNESP, Araraquara, State of Sao Paulo, Brazil; Veterinary Hospital, Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, São Paulo, Brazil
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Simone Henriques Mangia
Simone Henriques Mangia
Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP – Univ. Estadual Paulista, Botucatu, State of Sao Paulo, Brazil; Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, State of Sao Paulo, Brazil; Laboratory of Micobacteriology, Faculty of Pharmacy, UNESP, Araraquara, State of Sao Paulo, Brazil; Veterinary Hospital, Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, São Paulo, Brazil
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Jane Megid
Jane Megid
Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP – Univ. Estadual Paulista, Botucatu, State of Sao Paulo, Brazil; Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, State of Sao Paulo, Brazil; Laboratory of Micobacteriology, Faculty of Pharmacy, UNESP, Araraquara, State of Sao Paulo, Brazil; Veterinary Hospital, Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, São Paulo, Brazil
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Luiz Carlos Vulcano
Luiz Carlos Vulcano
Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP – Univ. Estadual Paulista, Botucatu, State of Sao Paulo, Brazil; Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, State of Sao Paulo, Brazil; Laboratory of Micobacteriology, Faculty of Pharmacy, UNESP, Araraquara, State of Sao Paulo, Brazil; Veterinary Hospital, Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, São Paulo, Brazil
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Gustavo Henrique Batista Lara
Gustavo Henrique Batista Lara
Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP – Univ. Estadual Paulista, Botucatu, State of Sao Paulo, Brazil; Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, State of Sao Paulo, Brazil; Laboratory of Micobacteriology, Faculty of Pharmacy, UNESP, Araraquara, State of Sao Paulo, Brazil; Veterinary Hospital, Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, São Paulo, Brazil
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Adolfo Carlos Barreto Santos
Adolfo Carlos Barreto Santos
Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP – Univ. Estadual Paulista, Botucatu, State of Sao Paulo, Brazil; Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, State of Sao Paulo, Brazil; Laboratory of Micobacteriology, Faculty of Pharmacy, UNESP, Araraquara, State of Sao Paulo, Brazil; Veterinary Hospital, Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, São Paulo, Brazil
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Clarice Queico Fujimura Leite
Clarice Queico Fujimura Leite
Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP – Univ. Estadual Paulista, Botucatu, State of Sao Paulo, Brazil; Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, State of Sao Paulo, Brazil; Laboratory of Micobacteriology, Faculty of Pharmacy, UNESP, Araraquara, State of Sao Paulo, Brazil; Veterinary Hospital, Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, São Paulo, Brazil
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Osimar de Carvalho Sanches
Osimar de Carvalho Sanches
Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP – Univ. Estadual Paulista, Botucatu, State of Sao Paulo, Brazil; Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, State of Sao Paulo, Brazil; Laboratory of Micobacteriology, Faculty of Pharmacy, UNESP, Araraquara, State of Sao Paulo, Brazil; Veterinary Hospital, Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, São Paulo, Brazil
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Antonio Carlos Paes
Antonio Carlos Paes
Department of Veterinary Hygiene and Public Health, School of Veterinary Medicine and Animal Science, UNESP – Univ. Estadual Paulista, Botucatu, State of Sao Paulo, Brazil; Department of Animal Reproduction and Veterinary Radiology, School of Veterinary Medicine and Animal Science, UNESP, Botucatu, State of Sao Paulo, Brazil; Laboratory of Micobacteriology, Faculty of Pharmacy, UNESP, Araraquara, State of Sao Paulo, Brazil; Veterinary Hospital, Universidade do Oeste Paulista, UNOESTE, Presidente Prudente, São Paulo, Brazil
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An uncommon disseminated Mycobacterium tuberculosis infection is described in a 12-year-old female dog presenting with fever, dyspnea, cough, weight loss, lymphadenopathy, melena, epistaxis, and emesis. The dog had a history of close contact with its owner, who died of pulmonary tuberculosis. Radiographic examination revealed diffuse radio-opaque images in both lung lobes, diffuse visible masses in abdominal organs, and hilar and mesenteric lymphadenopathy. Bronchial washing samples and feces were negative for acid-fast organisms. Polymerase chain reaction (PCR)-based species identification of bronchial washing samples, feces, and urine revealed M. tuberculosis using PCR-restriction enzyme pattern analysis-PRA. Because of public health concerns, which were worsened by the physical condition of the dog, euthanasia of the animal was recommended. Rough and tough colonies suggestive of M. tuberculosis were observed after microbiological culture of lung, liver, spleen, heart, and lymph node fragments in Löwenstein-Jensen and Stonebrink media. The PRA analysis enabled diagnosis of M. tuberculosis strains isolated from organs.
Author Notes
Authors' addresses: Anna Paula Vitirito Martinho, Marília Masello Junqueira Franco, Márcio Garcia Ribeiro, Isabella Belletti Mutt Perrotti, Simone Henriques Mangia, Jane Megid, Luiz Carlos Vulcano, Gustavo Henrique Batista Lara, and Antonio Carlos Paes, Universidade Estadual Paulista-UNESP “Júlio de Mesquita Filho,” Faculdade de Medicina Veterinária e Zootecnia, Departamento de Higiene Veterinária e Saúde Pública, Botucatu, SP, Brasil, E-mails: aninhavitty@uol.com.br, marilia_gu@uol.com.br, mgribeiro@fmvz.unesp.br, isinhabmp@yahoo.com.br, simangia@hotmail.com, jane@fmvz.unes.br, vulcano@fmvz.unesp.br, gunnys7@gmail.com, and paesacmi@fmvz.unesp.br. Adolfo Carlos Barreto Santos and Clarice Queico Fujimura Leite, Laboratório de Micobacteriologia, Faculdade de Farmácia, UNESP, Araraquara, SP, Brasil, E-mails: adolfo.barreto@terra.com.br and leitecqf@fcfar.unesp.br. Osimar de Carvalho Sanches, Laboratório de Patologia Veterinária, Hospital Veterinário, Universidade do Oeste Paulista - UNOESTE, Presidente Prudente, São Paulo, Brazil, E-mail: osimarsanches@yahoo.com.br.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Ministério da Saúde, 2011. Programa Nacional de Controle da Tuberculose. Secretaria de Vigilância em Saúde. Manual de Recomendações para o Controle da Tuberculose no Brasil. Brasil, Ministério da Saúde.
-
2.
Quinn PJ, Carter ME, Markey B, Carter GR, 1994. Clinical Veterinary Microbiology. London: Wolfe, 137–143.
-
3.
Telenti A, Marchesi F, Balz M, Bally F, Botrger EC, Bodmer T, 1993. Rapid identification of mycobacteria to the species level by polymerase chain reaction and restriction enzyme analysis. J Clin Microbiol 31: 175–178.
-
4.
Parish T, Staker NG, 1998. Mycobacterium protocols. Methods in Molecular Biology, 101. Totowa: Humana Press, 340–341.
-
5.
Acha PN, Szyfres B, 2003. Tuberculose zoonótica. Acha PN, Szyfres B, eds. Zoonosis y Enfermidades Transmisibles Communes al Hombre y a los Animals. Volume I. Washington: Organización Panamericana de la Salud, 266–283.
-
6.
Greene CE, Prescott JF, 2012. Mycobacterial infections. Greene CE, ed. Infectious Diseases of the Dog and Cat. Third edition. St. Louis, MO: Elsevier, 334–335.
-
7.
Parsons SDC, Gous TA, Warren RM, van Helden PD, 2008. Pulmonary Mycobacterium tuberculosis (Beijing strain) infection in a stray dog. J S Afr Vet Assoc 79: 95–98.
-
8.
Ministério da Saúde, 2005. Centro de Referência Professor Hélio Fraga. Manual de Bacteriologia da Tuberculose. Third edition. Brasil: Ministério da Saúde.
-
9.
Prasite, 2007. Identification of Mycobacteria. Available at: Http://app.chuv.ch/prasite/index.html.
-
10.
Chimara E, Ferrazoli L, Leão SC, 2004. Mycobacterium tuberculosis complex differentiation using gyrB restriction fragment length polymorphism analysis. Mem Inst Oswaldo Cruz 99: 745–748.
-
11.
LoBue PA, Enarson DA, Thoen CO, 2010. Tuberculosis in humans and animals: an overview. Int J Tuberc Lung Dis 14: 1075–1078.
-
12.
World Health Organization-WHO, 2011. Global Tuberculosis Control 2011. WHO/HTM/TB/2011. Geneva: WHO.
-
13.
Parsons SD, Warren RM, Ottenhoff TH, Gey van Pittius NC, van Helden PD, 2011. Detection of Mycobacterium tuberculosis infection in dogs in a high-risk setting. Res Vet Sci 92: 414–419.
-
14.
Megid J, Bracarense AP, Reis AC, Sturion DJ, Martin LM, Pinheiro SR, 1994. Tuberculose canina e sua importância em saúde pública. Rev Saude Publica 28: 309–310.
-
15.
Mota PM, Lobato FC, Assis RA, Lage AP, Parreiras PM, 2001. Isolamento de Mycobacterium bovis de cão. Arq Bras Med Vet Zootec 53: 410–412.
-
16.
Horn B, Forshaw D, Cousins D, Irwin PJ, 2000. Disseminated Mycobacterium avium infection in a dog with chronic diarrhea. Aust Vet J 78: 320–325.
-
17.
Bonovska M, Tzvetkov Y, Najdenski H, Bachvarova Y, 2005. PCR for detection of Mycobacterium tuberculosis in experimentally infected dogs. J Vet Med B 52: 165–170.
-
18.
Turinelli V, Ledieu D, Guilbaud L, Marchal T, Magnol JP, Fournel-Fleury C, 2004. Mycobacterium tuberculosis infection in a dog from Africa. Vet Clin Pathol 33: 177–181.
-
19.
Ma YH, Mo ZS, Pan H, Ban W, Hu Y, Yan ST, 1998. Investigation of tuberculosis in army and police dogs in South China. J Vet Sci 28: 12–15.
-
20.
Posthaus H, Bodmer T, Alves L, Oevermann A, Schiller I, Rhodes SG, Zimmerli S, 2011. Accidental infection of veterinary personnel with Mycobacterium tuberculosis at necropsy: a case study. Vet Microbiol 149: 374–380.
-
21.
Fabre M, Koeck J, Le Flèche F, Simon F, Hervé V, Vergnaud G, Pourcel C, 2004. High genetic diversity revealed by variable-number tandem repeat genotyping and analysis of hsp65 gene polymorphism in a large collection of Mycobacterium canetti strains indicates that the M. tuberculosis complex is a recently emerged clone of M. canetti. J Clin Microbiol 42: 3248–3255.
-
22.
De Jong BC, Antonio M, Gagneux S, 2010. Mycobacterium africanum—review of an important cause of human tuberculosis in West Africa. PLoS Negl Trop Dis 4: e744.
-
23.
Erwin PC, Bemis DA, McCombs SB, Sheeler LL, Himelright IM, Halford SK, Diem L, Metchock B, Jones TF, Schilling MG, Thomsen BV, 2004. Mycobacterium tuberculosis transmission from human to canine. Emerg Infect Dis 12: 2258–2260.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 356 | 278 | 22 |
| Full Text Views | 662 | 16 | 1 |
| PDF Downloads | 322 | 14 | 1 |