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Clinical and Epidemiological Study on Severe Fever with Thrombocytopenia Syndrome in Yiyuan County, Shandong Province, China

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  • Zibo Municipal Center for Disease Control and Prevention, Zibo City, Shandong Province, China; Yiyuan County Center for Disease Control and Prevention, Yiyuan, Shandong Province, China; Shandong Province Center for Disease Control and Prevention, Jinan, Shandong Province, China; School of Public Health, Shandong University, Jinan, People's Republic of China; Department of Pathology, University of Texas Medical Branch, Galveston, Texas
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Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in China. Polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect SFTS virus (SFTSV) and Anaplasma phagocytophilum in previous clinically diagnosed human anaplasmosis patients and SFTS patients. A serosurvey for SFTSV infection was also conducted on healthy persons and animals in Yiyuan County in Shandong Province of China. Among 21 patients SFTSV was detected in 17 (81%) however A. phagocytophilum was not detected in any of the patients. The seroprevalence rate of IgG antibody to SFTSV antigens was 1.3% (1 of 78) in healthy persons, 95% (19 of 20) in goats, 50% (1 of 2) in dogs, 0% in cattle (0 of 21), and rats (Rattus norvegicus) (0 of 35). The conclusion of this study was that co-infection of SFTSV and A. phagocytophilum are rare in SFTS patients and goats might play an important role in transmission of SFTSV.

Author Notes

* Address correspondence to Xue-Jie Yu, Department of Pathology, University of Texas Medical Branch, 301 University Blvd., Keiller Bldg. Galveston, TX 77555-0609. E-mail: xuyu@utmb.edu

Financial support: Ding S-J, Shandong Province CDC, was supported by the National Natural Science Foundation of China (Grant no. 81102171) and Shandong Medical Science and Technology Development Program (Grant no. 2011HZ055).

Authors' addresses: Feng Cui, Hai-Xia Cao, and Ling Wang, Zibo Center for Disease Control and Prevention, Zibo, Shandong Province of China, Epidemiology, Zibo, Shandong, China, E-mails: cuifeng@126.com, haixiacao@yahoo.cn, and Lucywl120@sina.com. Shou-Feng Zhang, Yiyuan County CDC, Infectious Diseases, Yiyuan, China, E-mail: yyxcdc@126.com. Shu-Jun Ding, Shandong Provincial Disease Prevention and Control Center, Department of Infectious Disease Control, Jinan, China, E-mail: dsj_jn@126.com. Xue-Jie Yu and Hao Yu, Shandong University, Jinan, China, and University of Texas Medical Branch, Pathology, Galveston, TX, E-mails: xuyu@utmb.edu and pnphappy@gamil.com.

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