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Clinical and Epidemiological Study on Severe Fever with Thrombocytopenia Syndrome in Yiyuan County, Shandong Province, China
Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease in China. Polymerase chain reaction and enzyme-linked immunosorbent assay were used to detect SFTS virus (SFTSV) and Anaplasma phagocytophilum in previous clinically diagnosed human anaplasmosis patients and SFTS patients. A serosurvey for SFTSV infection was also conducted on healthy persons and animals in Yiyuan County in Shandong Province of China. Among 21 patients SFTSV was detected in 17 (81%) however A. phagocytophilum was not detected in any of the patients. The seroprevalence rate of IgG antibody to SFTSV antigens was 1.3% (1 of 78) in healthy persons, 95% (19 of 20) in goats, 50% (1 of 2) in dogs, 0% in cattle (0 of 21), and rats (Rattus norvegicus) (0 of 35). The conclusion of this study was that co-infection of SFTSV and A. phagocytophilum are rare in SFTS patients and goats might play an important role in transmission of SFTSV.
Author Notes
Financial support: Ding S-J, Shandong Province CDC, was supported by the National Natural Science Foundation of China (Grant no. 81102171) and Shandong Medical Science and Technology Development Program (Grant no. 2011HZ055).
Authors' addresses: Feng Cui, Hai-Xia Cao, and Ling Wang, Zibo Center for Disease Control and Prevention, Zibo, Shandong Province of China, Epidemiology, Zibo, Shandong, China, E-mails: cuifeng@126.com, haixiacao@yahoo.cn, and Lucywl120@sina.com. Shou-Feng Zhang, Yiyuan County CDC, Infectious Diseases, Yiyuan, China, E-mail: yyxcdc@126.com. Shu-Jun Ding, Shandong Provincial Disease Prevention and Control Center, Department of Infectious Disease Control, Jinan, China, E-mail: dsj_jn@126.com. Xue-Jie Yu and Hao Yu, Shandong University, Jinan, China, and University of Texas Medical Branch, Pathology, Galveston, TX, E-mails: xuyu@utmb.edu and pnphappy@gamil.com.