Impact, Challenges, and Future Projections of Vaccine Trials in Africa

Olubukola T. Idoko Vaccinology Theme, Medical Research Council Unit, Banjul, The Gambia; PATH, New Delhi, India; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Kenya Medical Research Institute, Kisumu, Kenya

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Sonali Kochhar Vaccinology Theme, Medical Research Council Unit, Banjul, The Gambia; PATH, New Delhi, India; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Kenya Medical Research Institute, Kisumu, Kenya

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Tsiri E. Agbenyega Vaccinology Theme, Medical Research Council Unit, Banjul, The Gambia; PATH, New Delhi, India; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Kenya Medical Research Institute, Kisumu, Kenya

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Bernhards Ogutu Vaccinology Theme, Medical Research Council Unit, Banjul, The Gambia; PATH, New Delhi, India; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Kenya Medical Research Institute, Kisumu, Kenya

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Martin O. C. Ota Vaccinology Theme, Medical Research Council Unit, Banjul, The Gambia; PATH, New Delhi, India; Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Kenya Medical Research Institute, Kisumu, Kenya

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Immunization remains the most cost effective method for the control of infectious diseases. Therefore, there is a global effort to deploy new vaccines for disease control and eradication. These new vaccines must be tested in the settings in which they will be used. This necessity has required the conduct of many vaccine trials in Africa, where several infectious diseases with significant public health impact are prevalent. However, these areas have peculiarities and are just beginning to gain expertise in the conduct of such trials. The vaccine developers and sponsors of these trials may also not be conversant with some issues unique to the trial site. The understanding gap from both partners can result in challenges if not addressed during the planning phase of the trial. This review seeks to highlight the issues surrounding the conduct of clinical trials in resource-constrained settings and suggests some ways of circumventing them.

Author Notes

* Address correspondence to Olubukola T. Idoko, Medical Research Council, 6 Atlantic Road, Fajara, P.O. Box 273, The Gambia. E-mail: oidoko@mrc.gm

Authors' addresses: Olubukola T. Idoko, Department of Vaccinology, Medical Research Council Unit, Fajara, The Gambia, E-mail: oidoko@mrc.gm. Sonali Kochhar, Clinical Research and Drug Development, PATH, New Delhi, India, E-mail: skochhar@path.com. Tsiri E. Agbenyega, Department of Physiology, Kwame Nkurma University of Science and Technology, Kumasi, Ghana, E-mail: tsiri@ghana.com. Bernhards Ogutu, Department of Clinical Trials, Kenya Medical Research Institute, Kisumu, Kenya, E-mail: ogutu6@gmail.com. Martin O. C. Ota, Department of Vaccinology, Medical Research Council Unit, Fajara, The Gambia, E-mail: mota@mrc.gm.

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