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Antimalaria Action of Antiretroviral Drugs on Plasmodium berghei in Mice

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  • Department of Pharmacology, and Department of Hematology and Blood Transfusion, College of Medicine, University of Lagos, Lagos, Nigeria; Department of Biochemistry and Nutrition, Nigeria Institute of Medical Research, Yaba, Lagos, Nigeria

Malaria parasitemia enhances replication of human immunodeficiency virus. Antiretroviral drugs that possess antiplasmodial activity may reverse such an effect. Activity of the antiretroviral drugs lamivudine (L), zidovudine (Z), nevirapine (N), and stavudine (S) against Plasmodium berghei inoculated into 70 adult albino mice was investigated. Eight groups of five animals each were treated with different drugs as either curative or prophylactic regimens. These regimens were also given to four groups as L/Z/N or L/S/N. Z therapy alone and L/Z/N eliminated malaria parasites as follows: curative and prophylactic Z groups, mean ± SEM = 62,132.87 ± 22,816.1 parasites/μL and 62,474.85 ± 14,639.1 parasites/μL, respectively on day 4 and 0 parasites/μL on day 26; curative L/Z/N group, 31,583.53 ± 6,361.67 parasites/μL, and 0 parasites/μL (days 4 and 18, respectively); prophylactic L/Z/N group, 41,138.1 ± 3,528.03 parasites/μL, and 0 parasites/μL (days 4, and 20 respectively). Peters four-day suppressive values were 67–82.2%. Zidovudine or L/Z/N therapy may modify the epidemiology of malaria and therefore the pandemic of human immunodeficiency virus infection.

Author Notes

* Address correspondence to Akinwumi Akinyede, Department of Pharmacology, College of Medicine, University of Lagos, PMB 12003, Lagos, Nigeria. E-mail: a_akinyede@yahoo.co.uk

Authors' addresses: Akinwumi Akinyede, Alade Akintonwa, Olufunsho Awodele, Sunday Olayemi, and Ibrahim Oreagba, Department of Pharmacology, College of Medicine, University of Lagos, Lagos, Nigeria, E-mails: a_akinyede@yahoo.co.uk, toxicologyresearch@yahoo.com, awodeleo@yahoo.com, olayemiso@yahoo.com, and oreagbai@yahoo.com. Oluwagbemiga Aina and Samuel Akindele, Department of Biochemistry and Nutrition, Nigeria Institute of Medical Research, Yaba, Lagos, Nigeria, E-mails: gbengaaina2003@yahoo.com and samuelakindele@yahoo.com. Charles Okany, Department of Hematology and Blood Transfusion, College of Medicine, University of Lagos, Lagos, Nigeria, E-mail: charlesokany@yahoo.com.

Reprint requests: Akinwumi Akinyede, Department of Pharmacology, College of Medicine, University of Lagos, PMB 12003, Lagos, Nigeria, E-mail: a_akinyede@yahoo.co.uk.

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