Epidemic Distribution and Variation of Plasmodium falciparum and Plasmodium vivax Malaria in Hainan, China during 1995–2008

Dan Xiao Department of Epidemiology and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, and Department of Mathematics and Physics, School of Biomedical Science and Engineering, Fourth Military Medical University, Xi'an, China; Hainan Center for Disease Control and Prevention, Haikou, China

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Yong Long Department of Epidemiology and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, and Department of Mathematics and Physics, School of Biomedical Science and Engineering, Fourth Military Medical University, Xi'an, China; Hainan Center for Disease Control and Prevention, Haikou, China

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Shanqing Wang Department of Epidemiology and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, and Department of Mathematics and Physics, School of Biomedical Science and Engineering, Fourth Military Medical University, Xi'an, China; Hainan Center for Disease Control and Prevention, Haikou, China

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Kejian Wu Department of Epidemiology and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, and Department of Mathematics and Physics, School of Biomedical Science and Engineering, Fourth Military Medical University, Xi'an, China; Hainan Center for Disease Control and Prevention, Haikou, China

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Dezhong Xu Department of Epidemiology and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, and Department of Mathematics and Physics, School of Biomedical Science and Engineering, Fourth Military Medical University, Xi'an, China; Hainan Center for Disease Control and Prevention, Haikou, China

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Haitao Li Department of Epidemiology and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, and Department of Mathematics and Physics, School of Biomedical Science and Engineering, Fourth Military Medical University, Xi'an, China; Hainan Center for Disease Control and Prevention, Haikou, China

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Guangze Wang Department of Epidemiology and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, and Department of Mathematics and Physics, School of Biomedical Science and Engineering, Fourth Military Medical University, Xi'an, China; Hainan Center for Disease Control and Prevention, Haikou, China

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Yongping Yan Department of Epidemiology and the Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, and Department of Mathematics and Physics, School of Biomedical Science and Engineering, Fourth Military Medical University, Xi'an, China; Hainan Center for Disease Control and Prevention, Haikou, China

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Hainan Province is the main area threatened by malaria in China. However, the epidemiologic patterns of malaria in this region are not yet defined. In this study, we determined the spatio-temporal distribution and variation of Plasmodium falciparum and Plasmodium vivax malaria in Hainan during 1995–2008 by using wavelet and cluster quantitative approaches. The results indicated a decreasing secular trend and obvious seasonal fluctuation of malaria in Hainan. In addition, the characteristic annual peak of malaria could not be detected after 2005. The southcentral region of Hainan has remained an area of relatively high malaria risk, but the incidence of P. falciparum malaria increased significantly in the southeast and southwest regions during 2002–2008. These findings identify epidemic patterns of malaria in Hainan, and are applicable for designing an effective and dynamic public health campaign to combat malaria in this region.

Author Notes

* Address correspondence to Yongpin Yan, No. 169, Changle West Road, Xi'an, Shannxi, China 710032. E-mail: yanyping@fmmu.edu.cn
† These authors contributed equally to this article.

Financial support: This study was supported by National Special Grant for Prevention and Treatment of Infectious Diseases, China (2008ZX10004-012) and the Program for Changjiang Scholars and Innovative Research Team in University (PCSIRT).

Authors' addresses: Dan Xiao, Yong Long, Kejian Wu, Dezhong Xu, Haitao Li, and Yongping Yan, No. 169, Changle West Road, Xi'an, Shannxi, China, E-mails: danxiao@fmmu.edu.cn, longyong@fmmu.edu.cn, octopuspie@126.com, xudezh69@163.com, haitaoli@fmmu.edu.cn, and yanyping@fmmu.edu.cn. Shanqing Wang and Guangze Wang, 44 Haifu Road, Haikou, China, E-mails: wangsqkevin@163.com and wangguangze63@126.com.

  • 1.

    World Health Organization, 2010. World Malaria Report 2010. Available at: http://www.who.int/malaria/publications/atoz/9789241564106/en/. Accessed July 1, 2011.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 2.

    Ministry of Health of the People's Republic of China, 2010. Chinese Health Statistics Yearbook 2010. Available at: http://www.moh.gov.cn/publicfiles/business/htmlfiles/zwgkzt/ptjnj/year2010/index2010.html. Accessed October 1, 2011.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 3.

    Lin H, Lu L, Tian L, Zhou S, Wu H, Bi Y, Ho S, Liu Q, 2009. Spatial and temporal distribution of falciparum malaria in China. Malar J 8: 130.

  • 4.

    Zhou S, Tang L, Sheng H, Wang Y, 2006. Malaria situation in the People's Republic of China in 2004. Zhong Guo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi 24: 13.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 5.

    Xiao D, Long Y, Wang S, Fang L, Xu D, Wang G, Li L, Cao W, Yan Y, 2010. Spatiotemporal distribution of malaria and the association between its epidemic and climate factors in Hainan, China. Malar J 9: 185.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 6.

    Cazelles B, Chavez M, Magny GC, Guegan JF, Hales S, 2007. Time-dependent spectral analysis of epidemiological time-series with wavelets. J R Soc Interface 4: 625636.

  • 7.

    Grenfell BT, Bjornstad ON, Kappey J, 2001. Travelling waves and spatial hierarchies in measles epidemics. Nature 414: 716723.

  • 8.

    Broutin H, Guegan J, Elguero E, Simondon F, Cazelles B, 2005. Large-scale comparative analysis of pertussis population dynamics: periodicity, synchrony, and impact of vaccination. Am J Epidemiol 161: 11591167.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 9.

    Pascual M, Cazelles B, Bouma MJ, Chaves LF, Koelle K, 2008. Shifting patterns: malaria dynamics and rainfall variability in an African highland. Proc Biol Sci 275: 123132.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 10.

    Chaves LF, Pascual M, 2006. Climate cycles and forecasts of cutaneous leishmaniasis, a nonstationary vector-borne disease. PLoS Med 3: 13201328.

  • 11.

    Snow RW, Guerra CA, Noor AM, Myint HY, Hay SI, 2005. The global distribution of clinical episodes of Plasmodium falciparum malaria. Nature 434: 214217.

  • 12.

    Hay SI, Guerra CA, Gething PW, Patil AP, Tatem AJ, Noor AM, Kabaria GW, Manh BH, Elyazar IRF, Brooker S, Smith DL, Moyeed RA, Snow RW, 2009. A world malaria map: Plasmodium falciparum endemicity in 2007. PLoS Med 6: 286302.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 13.

    Munyekenye OG, Githeko AK, Zhou G, Mushinzimana E, Minakawa N, Yan G, 2005. Plasmodium falciparum spatial analysis, western Kenya highlands. Emerg Infect Dis 11: 15711577.

  • 14.

    Hui FM, Xu B, Chen ZW, Cheng X, Liang L, Huang HB, Fang LQ, Yang H, Zhou HN, Yang HL, Zhou XN, Cao WC, Gong P, 2009. Spatio-temporal distribution of malaria in Yunnan Province, China. Am J Trop Med Hyg 81: 503509.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 15.

    Clements AC, Barnett AG, Cheng ZW, Snow RW, Zhou HN, 2009. Space-time variation of malaria incidence in Yunnan Province, China. Malar J 8: 180.

  • 16.

    Zhang W, Wang L, Fang L, Ma J, Xu Y, Jiang J, Hui F, Wang J, Liang S, Yang H, Cao W, 2008. Spatial analysis of malaria in Anhui Province, China. Malar J 7: 206.

  • 17.

    Wang LP, Xu YF, Wang JJ, Xu X, Zhang WY, Fang LQ, Ma JQ, Cao WC, Jin SG, 2008. Spatial-temporal analysis on the distribution of malaria in Anhui, 1990–2006. Ji Bing Kong Zhi Za Zhi 12: 156159.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 18.

    Wen L, Xu DZ, Wang SQ, Li CX, Zhang ZY, Su YQ, 2003. Epidemic of malaria in Hainan Province and modeling malaria incidence with meteorological parameters. Ji Bing Kong Zhi Za Zhi 7: 520524.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 19.

    Fang L, Yan L, Liang S, de Vlas SJ, Feng D, Han X, Zhao W, Xu B, Bian L, Yang H, Gong P, Richardus JH, Cao W, 2006. Spatial analysis of hemorrhagic fever with renal syndrome in China. BMC Infect Dis 6: 77.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 20.

    Kulldorff M, Feuer EJ, Miller BA, Freedman LS, 1997. Breast cancer clusters in the northeast United States: a geographic analysis. Am J Epidemiol 146: 161170.

  • 21.

    Daubechies I, 1992. Ten Lectures on Wavelets. Series in Applied Mathematics Monographs. Philadelphia, PA: Society for Industrial and Applied Mathematics, 116.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 22.

    Kulldorff M, 1997. A spatial scan statistic. Comm Statist Theory Methods 26: 14811496.

  • 23.

    Kulldorff M, 2006. SatScan User Guide for Version 7.0. Available at: http://www.satscan.org/. Accessed March 9, 2010.

  • 24.

    Chaput EK, Meek JI, Heimer R, 2002. Spatial analysis of human granulocytic ehrlichiosis near Lyme, Connecticut. Emerg Infect Dis 8: 943948.

  • 25.

    Pitzer VE, Viboud C, Simonsen L, Steiner C, Panozzo CA, Alonso WJ, Miller MA, Glass RI, Glasser JW, Parashar UD, Grenfell BT, 2009. Demographic variability, vaccination, and the spatiotemporal dynamics of rotavirus epidemics. Science 325: 290294.

    • PubMed
    • Search Google Scholar
    • Export Citation
  • 26.

    Wang S, 2005. Evaluation of feasibility in elimination of Plasmodium falciparum malaria in Hainan Province. Zhong Guo Re Dai Yi Xue 5: 17791781.

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