Genetic Characterization of Atypical Mansonella (Mansonella) ozzardi Microfilariae in Human Blood Samples from Northeastern Peru

Luis A. Marcos Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri; Centro Nacional de Salud PĆŗblica, Instituto Nacional de Salud del Ministerio de Salud de PerĆŗ, Lima, Peru; Rabies Program, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Nancy Arrospide Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri; Centro Nacional de Salud PĆŗblica, Instituto Nacional de Salud del Ministerio de Salud de PerĆŗ, Lima, Peru; Rabies Program, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Sergio Recuenco Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri; Centro Nacional de Salud PĆŗblica, Instituto Nacional de Salud del Ministerio de Salud de PerĆŗ, Lima, Peru; Rabies Program, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Cesar Cabezas Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri; Centro Nacional de Salud PĆŗblica, Instituto Nacional de Salud del Ministerio de Salud de PerĆŗ, Lima, Peru; Rabies Program, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Gary J. Weil Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri; Centro Nacional de Salud PĆŗblica, Instituto Nacional de Salud del Ministerio de Salud de PerĆŗ, Lima, Peru; Rabies Program, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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Peter U. Fischer Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, Missouri; Centro Nacional de Salud PĆŗblica, Instituto Nacional de Salud del Ministerio de Salud de PerĆŗ, Lima, Peru; Rabies Program, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, Georgia

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DNA sequence comparisons are useful for characterizing proposed new parasite species or strains. Microfilariae with an atypical arrangement of nuclei behind the cephalic space have been recently described in human blood samples from the Amazon region of Peru. Three blood specimens containing atypical microfilariae were genetically characterized using three DNA markers (5S ribosomal DNA, 12S ribosomal DNA, and cytochrome oxidase I). All atypical microfilariae were clustered into the Mansonella group and indistinguishable from M. ozzardi based on these DNA markers.

Author Notes

* Address correspondence to Peter U. Fischer, Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St. Louis, MO 63110. E-mail: Pufische@DOM.Wustl.edu

Financial support: This study was supported by a grant from the Barnes Jewish Hospital Foundation.

Authors' addresses: Luis A. Marcos, Gary J. Weil, and Peter U. Fischer, Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, E-mails: marcoslrz@yahoo.com, GWeil@DOM.wustl.edu, and Pufische@DOM.wustl.edu. Nancy Arrospide and Cesar Cabezas, Centro Nacional de Salud PĆŗblica, Instituto Nacional de Salud del Ministerio de Salud de PerĆŗ, Lima, Peru, E-mails: narrospide@hotmail.com and ccabezas@ins.gob.pe. Sergio Recuenco, Rabies Program, National Center for Emerging and Zoonotic Infectious Diseases, Centers for Diseases and Prevention, Atlanta, GA, E-mail: fni9@cdc.gov.

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