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Artesunate for Severe Acute Plasmodium falciparum Infection in a Patient with Myasthenia Gravis

Nathalie DournonInfectious and Tropical Diseases Unit, Parasitology and Mycology Unit, and French National Center for Metropolitan Malaria, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Pierre et Marie Curie, Paris, France; Pasteur Institute, Paris, France; General Intensive Care Unit, Raymond Poincaré Hospital, Garches, France

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Pierre BuffetInfectious and Tropical Diseases Unit, Parasitology and Mycology Unit, and French National Center for Metropolitan Malaria, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Pierre et Marie Curie, Paris, France; Pasteur Institute, Paris, France; General Intensive Care Unit, Raymond Poincaré Hospital, Garches, France

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Eric CaumesInfectious and Tropical Diseases Unit, Parasitology and Mycology Unit, and French National Center for Metropolitan Malaria, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Pierre et Marie Curie, Paris, France; Pasteur Institute, Paris, France; General Intensive Care Unit, Raymond Poincaré Hospital, Garches, France

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Bernard ClairInfectious and Tropical Diseases Unit, Parasitology and Mycology Unit, and French National Center for Metropolitan Malaria, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Pierre et Marie Curie, Paris, France; Pasteur Institute, Paris, France; General Intensive Care Unit, Raymond Poincaré Hospital, Garches, France

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Stéphane JauréguiberryInfectious and Tropical Diseases Unit, Parasitology and Mycology Unit, and French National Center for Metropolitan Malaria, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris, France; Université Pierre et Marie Curie, Paris, France; Pasteur Institute, Paris, France; General Intensive Care Unit, Raymond Poincaré Hospital, Garches, France

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We report a case of severe malaria in a patient with underlying myasthenia gravis who was successfully treated with artesunate. The outcome was favorable. Artesunate seems to be a good option for patients with underlying myasthenia gravis disease because they benefit from a better toxicity profile than quinine.

Author Notes

* Address correspondence to Nathalie Dournon, Service des Maladies Infectieuses et Tropicales, Groupe Hospitalier Pitié-Salpêtrière, Assistance Publique-Hôpitaux, 47-83 Boulevard de l'Hôpital, F-75651, Paris, Cedex 13, France. E-mail: na_dournon@hotmail.com

Authors' addresses: Nathalie Dournon, Eric Caumes, and Stéphane Jauréguiberry, Infectious and Tropical Diseases Unit, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris 75013, France, E-mails: na_dournon@hotmail.com, eric.caumes@psl.aphp.fr, and stephane.jaureguiberry@psl.aphp.fr. Pierre Buffet, Parasitology and Mycology Unit, and French National Center for Metropolitan Malaria, Pitié-Salpêtrière Hospital, Assistance Publique-Hôpitaux de Paris, Paris 75013, France; Université Pierre et Marie Curie, Unite Mixte de Recherche 945, Paris 6, France; and Pasteur Institute, Paris 75015, E-mail: pabuffet@gmail.com. Bernard Clair, General Intensive Care Unit, Raymond Poincaré Hospital, Assistance Publique-Hôpitaux, Garches, France, E-mail: bernard.clair@rpc.aphp.fr.

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