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Molecular Characterization and Phylogenetic Analysis of Dengue Viruses Imported into Taiwan during 2008–2010

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  • Research and Diagnostic Center, Centers for Disease Control, Department of Health, Taipei, Taiwan, Republic of China

We present our surveillance results on imported dengue cases in Taiwan during 2008–2010. A total of 734 imported dengue patients were identified. The travelers were arriving from 18 countries, including Southeast Asia, the Indian subcontinent, South Pacific islands, and Latin America. Gene sequences from 358 dengue virus (DENV) isolates were used to perform phylogenetic analyses, thus, providing an updated view of the geographic distribution and dynamic transmission of DENV strains circulating in these countries. Our results suggest that the DENV-1 genotype I and DENV-2 Cosmopolitan genotype comprise the predominant DENV strains circulating in Southeast Asian countries. The DENV-3 Genotype III strain was found to be newly emerging in several Southeast Asian countries, however, the Asian genotype 2 and the Asian/American genotype of DENV-2 strains appeared to be less prevalent in Southeast Asia. Furthermore, imported dengue viruses are representative of the overall patterns of serotype/genotype frequencies of dengue outbreaks that occurred in Taiwan.

Author Notes

*Address correspondence to Pei-Yun Shu, Research and Diagnostic Center, Centers for Disease Control, Department of Health, 161, Kun-Yang Street, Taipei, Taiwan, R.O.C. E-mail: pyshu@cdc.gov.tw

Financial support: This work was supported by grants DOH98-DC-2010 and DOH99-DC-2024 from Centers for Disease Control, Department of Health, Taiwan, Republic of China.

Authors' addresses: Jyh-Hsiung Huang, Chien-Ling Su, Cheng-Fen Yang, Tsai-Ling Liao, Tung-Chien Hsu, Shu-Fen Chang, Chien-Chou Lin, and Pei-Yun Shu, Research and Diagnostic Center, Centers for Disease Control, Department of Health, Taipei, Taiwan, R.O.C., E-mails: jhhuang@cdc.gov.tw, sue@cdc.gov.tw, joyceyyang@cdc.gov.tw, tll@cdc.gov.tw, tchsu@cdc.gov.tw, vivi@cdc.tw, jjlin@cdc.gov.tw, and pyshu@cdc.gov.tw.

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