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Serum Aspergillus Galactomannan for the Management of Disseminated Histoplasmosis in AIDS

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  • Service des Maladies Infectieuses et Tropicales, Centre d’Infectiologie Necker – Pasteur, Paris, France; Service de Microbiologie, Hôpital Necker-Enfants Malades, Paris, France; Université Paris-Descartes, Paris, France; Institut Pasteur, Centre National de Référence Mycoses Invasives et Antifongiques, CNRS URA3012, Paris, France

Disseminated histoplasmosis is an emerging infection in patients with cellular immune deficiency in non-endemic countries, caused by the migration from endemic regions and the development of travels. Diagnosis can be challenging in this context because rapid diagnostic tools such as Histoplasma antigen detection or appropriate molecular tools are generally unavailable, serology is often negative in immunosuppressed patients, and isolation of the fungus from cultures often takes several weeks. Here, we report the contribution of galactomannan serum detection for the management of an HIV-infected patient with disseminated histoplasmosis.

Author Notes

*Address correspondence to Olivier Lortholary, Service des Maladies Infectieuses et Tropicales, Hôpital Necker – Enfants Malades, 149 rue de Sèvres, 75743 PARIS Cedex 15, France. E-mail: olivier.lortholary@pasteur.fr

Authors' addresses: Sébastien Rivière, Service des Maladies Infectieuses et Tropicales, Hôpital Necker – Enfants Malades, Paris, France; present address: Service de Médecine Interne, hôpital Saint-Antoine, Paris, France, E-mail: sebastien.riviere@sat.aphp.fr. Blandine Denis, Fanny Lanternier, and Marc Lecuit, Service des Maladies Infectieuses et Tropicales, Hôpital Necker – Enfants Malades, Paris, France, E-mails: blandine.denis@nck.aphp.fr, fanny.lanternier@nck.aphp.fr, and marc.lecuit@nck.aphp.fr. Marie-Elisabeth Bougnoux, Service de Microbiologie, Hôpital Necker – Enfants Malades, 149 rue de Sèvres, 75743 PARIS Cedex 15, E-mail: marie-elisabeth.bougnoux@nck.aphp.fr. Olivier Lortholary, Institut Pasteur, Centre National de Référence Mycologie et Antifongiques, Unité de Mycologie Moléculaire, Paris, France; and Service des Maladies Infectieuses et Tropicales, Hôpital Necker – Enfants Malades, Paris, France, E-mail: olivier.lortholary@pasteur.fr.

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