Consecutive Cutaneous and Visceral Leishmaniasis Manifestations Involving a Novel Leishmania Species in Two HIV Patients in Thailand

Sarunyou Chusri Division of Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand; Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

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Thanaporn Hortiwakul Division of Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand; Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

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Khachornsakdi Silpapojakul Division of Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand; Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

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Padet Siriyasatien Division of Infectious Diseases, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand; Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand

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Leishmaniasis is an emerging disease in Thailand. Herein, we report on two human immunodeficiency virus (HIV)-infected patients with leishmaniasis who presented with overlapping manifestations between cutaneous and visceral leishmaniasis. Sequencing analysis of the internal transcribed spacer 1 (ITS1) of the ribosomal RNA gene showed that the species was identical to a new species recently described in Thailand. The detection of DNA of this Leishmania species in saliva may have important implications for transmission and epidemiological studies.

Author Notes

*Address correspondence to Sarunyou Chusri, Division of Infectious Disease, Department of Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand. E-mail: sarunyouchusri@hotmail.com

Authors' addresses: Sarunyou Chusri, Thanaporn Hortiwakul, and Khachornsakdi Silpapojakul, Division of Infectious Disease, Department of Internal Medicine, Faculty of Medicine, Prince of Songkla University, Songkhla, Thailand, E-mails: sarunyouchusri@hotmail.com, hratri@medicine.psu.ac.th, and skhachor@medicine.psu.ac.th. Padet Siriyasatien, Department of Parasitology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand, E-mail: padetcu@gmail.com.

  • 1.

    Cupolillo E, Grimaldi G Jr, Momen H, 1994. A general classification of New World Leishmania using numerical zymotaxonomy. Am J Trop Med Hyg 50: 296311.

    • Search Google Scholar
    • Export Citation
  • 2.

    World Health Organization, 1990. Control of the Leishmaniasis. Technical Report Series 793. Geneva: WHO, 2125.

  • 3.

    Murray HW, Berman JD, Davies CR, Saravia NG, 2005. Advances in leishmaniasis. Lancet 366: 15611577.

  • 4.

    Alvar J, Aparicio P, Aseffa A, Den Boer M, Cañavate C, Dedet JP, Gradoni L, Ter Horst R, López-Vélez R, Moreno J, 2008. The relationship between leishmaniasis and AIDS: the second 10 years. Clin Microbiol Rev 21: 334359.

    • Search Google Scholar
    • Export Citation
  • 5.

    Viriyavejakul P, Viravan C, Riganti M, Punpoowong B, 1997. Imported cutaneous leishmaniasis in Thailand. Southeast Asian J Trop Med Public Health 28: 558562.

    • Search Google Scholar
    • Export Citation
  • 6.

    Thisyakorn U, Jongwutiwes S, Vanichsetakul P, Lertsapcharoen P, 1999. Visceral leishmaniasis: the first indigenous case report in Thailand. Trans R Soc Trop Med Hyg 93: 2324.

    • Search Google Scholar
    • Export Citation
  • 7.

    Sukmee T, Siripattanapipong S, Mungthin M, Worapong J, Rangsin R, Samung Y, Kongkaew W, Bumrungsana K, Chanachai K, Apiwathanasorn C, Rujirojindakul P, Wattanasri S, Ungchusak K, Leelayoova S, 2008. A suspected new species of Leishmania, the causative agent of visceral leishmaniasis in a Thai patient. Int J Parasitol 38: 617622.

    • Search Google Scholar
    • Export Citation
  • 8.

    Suankratay C, Suwanpimolkul G, Wilde H, Siriyasatien P, 2010. Case report: autochthonous visceral leishmaniasis in a human immunodeficiency virus (HIV)-infected patient: the first in Thailand and review of the literature. Am J Trop Med Hyg 82: 48.

    • Search Google Scholar
    • Export Citation
  • 9.

    Maharom P, Siripattanapipong S, Mungthin M, Naaglor T, Sukkawee R, Pudkorn R, Wattana W, Wanachiwanawin D, Areechokchai D, Leelayoova S, 2008. Visceral leishmaniasis caused by Leishmania infantum in Thailand. Southeast Asian J Trop Med Public Health 39: 988990.

    • Search Google Scholar
    • Export Citation
  • 10.

    Bureau of Epidemiology, Department of Disease Control, Ministry of Public Health, Thailand, 2010. Annual reports of opportunistic infection in thai HIV infected-patient (Thai). Available at: http://www.boe.moph.go.th/files/report/20110401_19956923.pdf. Accessed November 1, 2011.

    • Search Google Scholar
    • Export Citation
  • 11.

    Ridley DS, Ridley MJ, 1983. The evolution of the lesion in cutaneous leishmaniasis. J Pathol 141: 8396.

  • 12.

    Weigle KA, Davalos MD, Heredia P, 1987. Diagnosis of cutaneous and mucocutaneous leishmaniasis in Colombia: a comparison of seven methods. Am J Trop Med Hyg 36: 489496.

    • Search Google Scholar
    • Export Citation
  • 13.

    Albrecht H, Sobottka I, Emminger C, 1996. Visceral leishmaniasis emerging as an important opportunistic infection in HIV-infected persons living in areas nonendemic for Leishmania donovani. Arch Pathol Lab Med 120: 189198.

    • Search Google Scholar
    • Export Citation
  • 14.

    Hofman V, Marty P, Perrin C, 2000. The histological spectrum of visceral leishmaniasis caused by Leishmania infantum MON-1 in acquired immune deficiency syndrome. Hum Pathol 31: 7584.

    • Search Google Scholar
    • Export Citation
  • 15.

    Mimori T, Sasaki J, Nakata M, Gomez EA, Uezato H, Nonaka S, 1998. Rapid identification of Leishmania species from formalin-fixed biopsy samples by polymorphism-specific polymerase chain reaction. Gene 210: 179186.

    • Search Google Scholar
    • Export Citation
  • 16.

    Pirmez C, da Silva Trajano V, Paes-Oliveira Neto MP, da-Cruz AM, Gonçalves-da-Costa SC, Catanho M, 1999. Use of PCR in diagnosis of human American tegumentary leishmaniasis in Rio de Janeiro, Brazil. J Clin Microbiol 37: 18191823.

    • Search Google Scholar
    • Export Citation
  • 17.

    Forkner CE, Zia LS, 1934. Viable Leishmania donovani in nasal and oral secretions of patients with kala-azar and the bearing of this finding on the transmission of the disease. J Exp Med 59: 491499.

    • Search Google Scholar
    • Export Citation
  • 18.

    Romero GA, Sampaio RN, Macedo V de O, Marsden PD, 1999. Sensitivity of a vacuum aspiratory culture technique for diagnosis of localized cutaneous leishmaniasis in an endemic area of Leishmania (Viannia) braziliensis. Mem Inst Oswaldo Cruz 94: 505508.

    • Search Google Scholar
    • Export Citation
  • 19.

    Galaï Y, Chabchoub N, Ben-Abid M, Ben-Abda I, Ben-Alaya-Bouafif N, Amri F, Aoun K, Bouratbine A, 2011. Diagnosis of Mediterranean visceral leishmaniasis by detection of Leishmania antibodies and Leishmania DNA in oral fluid samples collected using an Oracol device. J Clin Microbiol 49: 31503153.

    • Search Google Scholar
    • Export Citation
  • 20.

    Spanakos G, Piperaki ET, Menounos PG, Tegos N, Flemetakis A, Vakalis NC, 2008. Detection and species identification of Old World Leishmania in clinical samples using a PCR-based method. Trans R Soc Trop Med Hyg 102: 4653.

    • Search Google Scholar
    • Export Citation
  • 21.

    Magill AJ, Grogl M, Johnson SC, Gasser RA Jr, 1994. Visceral infection due to Leishmania tropica in a veteran of operation Desert Storm who presented 2 years after leaving Saudi Arabia. Clin Infect Dis 19: 805806.

    • Search Google Scholar
    • Export Citation
  • 22.

    Guerin PJ, Olliaro P, Sundar S, Boelaert M, Croft SL, Desjeux P, 2002. Visceral leishmaniasis: current status of control, diagnosis, and treatment, and a proposed research and development agenda. Lancet Infect Dis 2: 494501.

    • Search Google Scholar
    • Export Citation
  • 23.

    Rodriguez-Bonfante C, Bonfante-Garrido R, Grimaldi G Jr, Momen H, Cupolillo E, 2003. Genotypically distinct Leishmania colombiensis isolates from Venezuela cause both cutaneous and visceral leishmaniasis in humans. Infect Genet Evol 3: 119124.

    • Search Google Scholar
    • Export Citation
  • 24.

    Dowlati Y, 1996. Cutaneous leishmaniasis: clinical aspects. Clin Dermatol 14: 425431.

  • 25.

    Weigle K, Saravia NG, 1996. Natural history, clinical evaluation, and the host-parasite interaction in New World cutaneous leishmaniasis. Clin Dermatol 14: 433450.

    • Search Google Scholar
    • Export Citation
  • 26.

    Marovich M, Lira R, Shepard M, Fuchs G, Kruetzer R, Nutmann T, Neva F, 2001. Leishmaniasis recidivans recurrence after 43 years: a clinical and immunologic report after successful treatment. Clin Infect Dis 33: 10761079.

    • Search Google Scholar
    • Export Citation
  • 27.

    Mebrahtu YB, Hendricks LD, Oster CN, Lawyer PG, Perkins PV, Pamba H, 1993. Leishmania donovani parasites in the nasal secretions, tonsillopharyngeal mucosa, and urine centrifugates of visceral leishmaniasis patients in Kenya. Am J Trop Med Hyg 48: 530535.

    • Search Google Scholar
    • Export Citation
  • 28.

    Shorft HE, Smith ROA, D'Silva HAH, Swaminath CS, 1923. Leishmania donovani in human faeces in Indian kala-azar. Indian J Med Res 17: 644646.

    • Search Google Scholar
    • Export Citation
  • 29.

    Shortt HE, Swaminath CS, 1937. The viability of Leishmania donovani excreted in the nasal mucus in Indian kala-azar. Indian J Med Res 25: 341343.

    • Search Google Scholar
    • Export Citation
  • 30.

    Corvalan FH, Sampaio RNR, Brustoloni YM, Andreotti R, Lima MSC Jr, 2011. DNA identification of Leishmania (Viannia) braziliensis in human saliva from a patient with American cutaneous leishmaniasis. J Venom Anim Toxins Trop Dis 17: 98102.

    • Search Google Scholar
    • Export Citation
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