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Effect of Filarial Infection on Serum Inflammatory and Atherogenic Biomarkers in Coronary Artery Disease (CURES-121)

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  • Laboratory of Molecular Immunology, AU-KBC Research Centre, Anna University, Chennai, India; Madras Diabetes Research Foundation, Chennai, India; Dr. Mohan's Diabetes Specialties Centre, Chennai, India; National Institutes of Health-International Center for Excellence in Research, Chennai, India

Helminth infections can potentially confer protection against metabolic disorders, possibly through immunomodulation. In this study, the baseline prevalence of lymphatic filariasis (LF) among subjects without (N = 236) and with (N = 217) coronary artery disease (CAD) was examined as part of the Chennai Urban Rural Epidemiological Study (CURES). The prevalence of LF was not significantly different between CAD and CAD+ subjects. The LF antigen load and antibody levels indicated comparable levels of infection and exposure between the groups. Within the CAD group, LF+ and LF subjects had no significant difference in the intimal medial thickness and high-sensitivity C-reactive protein values. However, LF infection was associated with augmented levels of tumor necrosis factor-α and interleukin-6 among CAD+ subjects. The LF infection had no effect on serum adipocytokine profile. In conclusion, unlike type-2 diabetes, there is no association between the prevalence of LF and CAD and also no evidence of protective immunomodulation of LF infection on CAD in the Asian Indian population.

Author Notes

*Address correspondence to Vivekanandhan Aravindhan, Laboratory of Molecular Immunology, AU-KBC Research Centre, Anna University, Chennai-600044, India. E-mails: cvaravindhan@yahoo.co.uk or cvaravindhan@gmail.com

Financial support: This work received partial support from the Intramural Research Program of the Division of Intramural Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, through the NIAID/TRC ICER program and KB Chandrasekhar Research Foundation, India.

Authors' addresses: Vivekanandhan Aravindhan, Anna University-KB Chandrasekhar Research Centre, MIT Campus of Anna University, Chrompet, Chennai, India, E-mail: cvaravindhan@gmail.com. Vishwanathan Mohan, Jayagopi Surendar, Mardana Muralidhara Rao, and Mohan Deepa, Madras Diabetes Research Foundation, Chennai, India, E-mails: drmohans@vsnl.net, surendarj85@gmail.com, raoinfoster@gmail.com, and deepa.mohan1@gmail.com. Rajamanickam Anuradha, Tuberculosis Research Center-National Institutes of Health-International Center for Excellence in Research, Chetpet, Chennai, India, E-mail: anuvenil@gmail.com. Subash Babu, Tuberculosis Research Center, Chennai, India; National Institutes of Health-International Center for Excellence in Research, Chetpet, Chennai, India; and SAIC Frederick, Inc., NCI Frederick, Frederick, MD, E-mail: sbabu@mail.nih.gov.

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