Reversible Posterior Leukoencephalopathy in a Venomous Snake (Bothrops asper) Bite Victim

Miguel E. Delgado Intensive Care Unit, Hospital de Infectología Daniel Rodríguez Maridueña, Ministerio de Salud Pública, Guayaquil, Ecuador; Department of Neurological Sciences, Hospital-Clínica Kennedy, Guayaquil, Ecuador

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Oscar H. Del Brutto Intensive Care Unit, Hospital de Infectología Daniel Rodríguez Maridueña, Ministerio de Salud Pública, Guayaquil, Ecuador; Department of Neurological Sciences, Hospital-Clínica Kennedy, Guayaquil, Ecuador

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An 18-year-old man developed posterior reversible leukoencephalopaty after being bitten by a venomous snake (Bothrops asper). It is possible that this previously unrecognized neurological complication of snake bite envenoming occurred as the result of endothelial dysfunction induced by the venom of the offending snake. This pathogenetic mechanism has also been implicated as the cause of cerebral infarctions in snake bite victims. Alternatively, the leukoencephalopathy might have been a complication of antivenom therapy.

Author Notes

*Address correspondence to Oscar H. Del Brutto, Air Center 3542, PO Box 522970, Miami, FL 33152-2970. E-mail: odbp@gye.satnet.net

Authors' addresses: Miguel E. Delgado, Intensive Care Unit, Hospital de Infectología Daniel Rodríguez Maridueña, Ministerio de Salud Pública, Guayaquil, Ecuador, E-mail: drmiguel_delgado@yahoo.com. Oscar H. Del Brutto, Department of Neurological Sciences, Hospital-Clínica Kennedy, Guayaquil, Ecuador, E-mail: odbp@gye.satnet.net.

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