Efficacy of a Single Oral Dose of Oxfendazole against Fasciola hepatica in Naturally Infected Sheep

Luis A. Gomez-Puerta School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru; Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru

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Cesar Gavidia School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru; Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru

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Maria T. Lopez-Urbina School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru; Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru

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Hector H. Garcia School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru; Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru

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Armando E. Gonzalez School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru; Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru

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for The Cysticercosis Working Group in Peru School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru; Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru

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The efficacy of a single oral dose of 30 mg/kg of oxfendazole against Fasciola hepatica was evaluated in a controlled study in naturally infected sheep. Sheep were diagnosed by stool microscopy after sedimentation, and positive animals were randomized to oxfendazole (N = 20) or no treatment (N = 20). A new stool exam was performed 10 days after treatment. All stool microscopies were performed masked to the treatment group. No side effects were noticed. All sheep in the control group remained infected with similar counts of eggs per gram of stools. None of the animals in the treatment group showed Fasciola eggs in stools after 10 days of treatment. A single dose of oxfendazole is highly effective against F. hepatica, providing a new drug alternative for the control of fascioliasis or integrated zoonosis control.

Author Notes

*Address correspondence to Luis A. Gomez-Puerta, School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Av. Circunvalación 2800, Lima 41, Peru. E-mail: lucho92@yahoo.com

Financial support: This work was supported by Fogarty/NIH (grants D43TW008273 and D43TW001140). HG is supported by a Wellcome Trust International Senior Research Fellowship.

Authors’ addresses: Luis A. Gomez-Puerta, Cesar Gavidia, Maria T. Lopez-Urbina, and Armando E. Gonzalez, School of Veterinary Medicine, Universidad Nacional Mayor de San Marcos, Lima, Peru, E-mails: lucho92@yahoo.com, cgavidia@jhsph.edu,mtlu@terra.com.pe, and agonzale@jhsph.edu. Hector H. Garcia, Department of Microbiology, School of Sciences, Universidad Peruana Cayetano Heredia, Lima, Peru, E-mail: hgarcia@jhsph.edu.

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