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There is a high prevalence of fascioliasis in the Peruvian highlands, but most cases remain undiagnosed. The burden of disease caused by chronic subclinical infection is largely unknown. We studied school-age children from a district in Paucartambo Province in Cusco, Peru to evaluate the burden of disease caused by subclinical fascioliasis. Parasite eggs and/or larvae were identified in 46.2% of subjects, including Fasciola hepatica in 10.3% of subjects. Fascioliasis was independently associated with anemia (adjusted odds ratio = 3.01 [1.10–8.23]). Subclinical fascioliasis was common among children and strongly associated with anemia. Anemia should be recognized as an important component of the burden of disease from fascioliasis.
Financial support: No funding was received to performed this study
Authors' addresses: Martha Lopez, Laboratorio Clinico Ser Salud, Cusco, Peru, E-mail: firstname.lastname@example.org. A. Clinton White Jr., Infectious Diseases Division, University of Texas Medical Branch, Galveston, TX, E-mail: email@example.com. Miguel M. Cabada, Instituto de Medicina Tropical Alexander von Humboldt, Lima, Peru, and Infectious Diseases Division, University of Texas Medical Branch, Galveston, TX, E-mail: firstname.lastname@example.org.