ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2009. Fascioliasis: infection with the “neglected” neglected worms. Available at: http://www.who.int/neglected_diseases/integrated_media/integrated_media_fascioliasis/en/index.html. Accessed June 4, 2011.
-
2.
Mas-Coma S, Valero MA, Bargues MD, 2009. Chapter 2: Fasciola, lymnaeids, and human fascioliasis, with a global overview of disease transmission, epidemiology, evolutionary genetics, molecular epidemiology, and control. Adv Parasitol 69: 41– 146.
-
3.
Mas-Coma MS, Esteban JG, Bargues MD, 1999. Epidemiology of human fascioliasis: a review and proposed new classification. Bull World Health Organ 77: 340– 346.
-
4.
Marcos LA, Tagle M, Terashima A, Bussalleu A, Ramirez C, Carrasco C, Valdez L, Huerta-Mercado J, Freedman DO, Vinetz JM, Gotuzzo E, 2008. Natural history, clinicoradiologic correlates, and response to triclabendazole in acute massive fascioliasis. Am J Trop Med Hyg 78: 222– 227.
-
5.
Blancas G, Terashima A, Maguina C, Vera L, Alvarez H, Tello R, 2004. Human fascioliasis and gastrointestinal involvement: review of 277 cases seen between 1970 and 2002 at Hospital Nacional Cayetano Heredia. Rev Gastroenterol Peru 24: 143– 157.
-
6.
Marcos LA, Maco V, Castillo M, Terashima A, Zerpa R, Gotuzzo E, 2005. Case series of fascioliasis seen between 1988 and 2003 at Instituto Especializado de Salud del Niño, Lima-Peru. Rev Gastroenterol Peru 25: 198– 205.
-
7.
Marcos LA, Terashima A, Leguia G, Canales M, Espinoza JR, Gotuzzo E, 2007. Fasciola hepatica infection in Peru: an emerging disease. Rev Gastroenterol Peru 27: 389– 396.
-
8.
Marcos LA, Maco V, Terashima A, Samalvides F, Gotuzzo E, 2002. Clinical characteristics of Fasciola hepatica infection in children. Rev Gastroenterol Peru 22: 228– 233.
-
9.
Madan N, Rusia U, Sikka M, Sharma S, Shankar N, 2011. Developmental and neurophysiologic deficits in iron deficiency children. Indian J Pediatr 78: 58– 64.
-
10.
Marcos LA, Yi P, Machicado A, Andrade R, Samalvides F, Sanchez J, Terashima A, 2007. Hepatic fibrosis and Fasciola hepatica infection in cattle. J Helminthol 81: 381– 386.
-
11.
Marcos LA, Bussalleu A, Terashima A, Espinoza JR, 2009. Detection of antibodies against Fasciola hepatica in cirrhotic patients from Peru. Helminthol 83: 23– 26.
-
12.
Maco-Flores V, Marcos-Raymundo L, Terashima-Iwashita A, Samalvides-Cuba F, Miranda-Sanchez E, Espinoza-Babilon J, Gotuzzo-Herencia E, 2002. Fas-2 ELISA and the rapid sedimentation technique modified by Lumbreras for Fasciola hepatica infection diagnosis. Rev Med Hered 13: 49– 57.
-
13.
Terashima A, Marcos L, Maco V, Canales M, Samalvides F, Tello R, 2009. Highly sensitive in test tube sedimentation technique for the diagnosis of intestinal parasites. Rev Gastroenterol Peru 29: 305– 310.
-
14.
Nestel P, 2002. Adjusting Hemoglobin Values in Program Surveys. For the International Nutritional Anemia Consultative Group. Available at: http://pdf.usaid.gov/pdf_docs/PNACQ927.pdf. Accessed June 2, 2011.
-
15.
Dirren H, Logman MH, Barclay DV, Freire WB, 1994. Altitude correction for hemoglobin. Eur J Clin Nutr 48: 625– 632.
-
16.
World Health Organization, 2001. Iron Deficiency Anaemia Assessment, Prevention and Control: A Guide for Programme Managers. Available at: http://www.who.int/nutrition/publications/en/ida_assessment_prevention_control.pdf. Accessed June 4, 2011.
-
17.
De Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J, 2007. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 85: 660– 667.
-
18.
World Health Organization, 2011. Application Tools: WHO AnthroPlus Manual. Available at: http://www.who.int/growthref/tools/en/. Accessed June 4, 2011.
-
19.
Zevallos K, Vergara KC, Vergara A, Vidal C, Garcia HH, Evans CA, 2010. Tuberculin skin-test reactions are unaffected by the severity of hyperendemic intestinal helminth infections and co-infections. Am J Trop Med Hyg 83: 319– 325.
-
20.
Maco-Flores V, Marcos-Raymundo LA, Terashima-Iwashita A, Samalvides-Cuba F, Gotuzzo-Herencia E, 2002. Distribution of enteric parasites in the Peruvian Altiplano: a study in 6 communities in Puno, Peru. Rev Gastroenterol Peru 22: 304– 309.
-
21.
Cabrera M, Verastegui M, Cabrera R, 2005. Prevalence of enteric parasites in a highland community of the Victor Fajardo Province, Ayacucho, Peru. Rev Gastroenterol Peru 25: 150– 155.
-
22.
INEI, 2010. Peruvian Poverty Map by Province and District 2009: Focused on Income. Available at: http://www.unfpa.org.pe/publicaciones/publicacionesperu/INEI-Mapa-Pobreza-2009. Accessed June 4, 2011.
-
23.
Ngui R, Ishak S, Chuen CS, Mahmud R, Lim YA, 2011. Prevalence and risk factors of intestinal parasitism in rural and remote west Malaysia. PLoS Negl Trop Dis 5: e974.
-
24.
Quihui I, Valencia ME, Cromptom DW, Phillips S, Hagan P, Morales G, Diaz-Camacho SP, 2006. Role of the employment status and education of mothers in the prevalence of intestinal parasitic infections in Mexican rural schoolchildren. BMC Public Health 6: 225.
-
25.
Marcos LA, Terashima A, Gotuzzo E, 2008. Update on hepatobiliary flukes: fascioliasis, opisthorchiasis, and clonorchiasis. Curr Opin Infect Dis 21: 523– 530.
-
26.
Mas-Coma S, Angles R, Esteban JG, Bargues MD, Buchon P, Franken M, Strauss W, 1999. The northern Bolivian Altiplano: a region highly endemic for human fascioliasis. Trop Med Int Health 4: 454– 467.
-
27.
Marcos L, Romani L, Florencio L, Terashima A, Canales M, Nestares J, Huayanay L, Gotuzzo E, 2007. Hyperendemic and mesoendemic areas for Fasciola hepatica infection near Lima: an emerging illness? Rev Gastroenterol Peru 27: 21– 26.
-
28.
Parkinson M, O'Neill SM, Dalton JP, 2007. Endemic human fascioliosis in the Bolivian Altiplano. Epidemiol Infect 135: 669– 674.
-
29.
Marcos L, Maco V, Samalvides F, Terashima A, Espinoza JR, Gotuzzo E, 2006. Risk factors for Fasciola hepatica infection in children: a case-control study. Trans R Soc Trop Med Hyg 100: 158– 166.
-
30.
Mas-Coma S, Funatsu IR, Bargues MD, 2001. Fasciola hepatica and lymnaeid snails occurring at very high altitude in South America. Parasitology 123: S115– S127.
-
31.
Grantham-McGregor S, Cheung YB, Cueto S, Glewwe P, Richter L, Strupp B; International Child Development Steering Group, 2007. Child development in developing countries 1: developmental potential in the first 5 years for children in developing countries. Lancet 369: 60– 70.
-
32.
Gyorkos TW, Maheu-Giroux M, Casapia M, Joseph SA, Creed-Kanashiro H, 2011. Stunting and helminths infection in early preschool-age children in a resource-poor community in the Amazon lowlands of Peru. Trans R Soc Trop Med Hyg 105: 204– 208.
-
33.
Casapia M, Joseph SA, Nunez C, Rahme E, Gyorkos TW, 2006. Parasite risk factors for stunting in grade 5 students in a community of extreme poverty in Peru. Int J Parasitol 36: 741– 747.
-
34.
King CH, 2010. Health metrics for helminth infections. Adv Parasitol 73: 51– 69.
-
35.
El-Shazly AM, El-Nahas HA, Abdel-Mageed AA, El Beshbishi SN, Azab MS, El Hasan MA, Arafa WA, Morsy TA, 2005. Human fascioliasis and aneamia in Dakahlia governorate, Egypt. J Egypt Soc Parasitol 35: 421– 432.
| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 1341 | 1184 | 433 |
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Burden of Fasciola hepatica Infection among Children from Paucartambo in Cusco, Peru
Martha Lopez
Martha Lopez
Laboratorio Clinico Ser Salud, Cusco, Peru; Infectious Diseases Division, University of Texas Medical Branch, Galveston, Texas; Tropical Medicine Institute, Universidad Peruana Cayetano Heredia, Lima, Peru
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A. Clinton White Jr
A. Clinton White Jr
Laboratorio Clinico Ser Salud, Cusco, Peru; Infectious Diseases Division, University of Texas Medical Branch, Galveston, Texas; Tropical Medicine Institute, Universidad Peruana Cayetano Heredia, Lima, Peru
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Miguel M. Cabada
Miguel M. Cabada
Laboratorio Clinico Ser Salud, Cusco, Peru; Infectious Diseases Division, University of Texas Medical Branch, Galveston, Texas; Tropical Medicine Institute, Universidad Peruana Cayetano Heredia, Lima, Peru
Search for other papers by Miguel M. Cabada in
Current site
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PubMed
Search for other papers by Miguel M. Cabada in
Current site
Google Scholar
PubMed
There is a high prevalence of fascioliasis in the Peruvian highlands, but most cases remain undiagnosed. The burden of disease caused by chronic subclinical infection is largely unknown. We studied school-age children from a district in Paucartambo Province in Cusco, Peru to evaluate the burden of disease caused by subclinical fascioliasis. Parasite eggs and/or larvae were identified in 46.2% of subjects, including Fasciola hepatica in 10.3% of subjects. Fascioliasis was independently associated with anemia (adjusted odds ratio = 3.01 [1.10–8.23]). Subclinical fascioliasis was common among children and strongly associated with anemia. Anemia should be recognized as an important component of the burden of disease from fascioliasis.
Author Notes
Financial support: No funding was received to performed this study
Authors' addresses: Martha Lopez, Laboratorio Clinico Ser Salud, Cusco, Peru, E-mail: martlop2000@gmail.com. A. Clinton White Jr., Infectious Diseases Division, University of Texas Medical Branch, Galveston, TX, E-mail: acwhite@utmb.edu. Miguel M. Cabada, Instituto de Medicina Tropical Alexander von Humboldt, Lima, Peru, and Infectious Diseases Division, University of Texas Medical Branch, Galveston, TX, E-mail: micabada@utmb.edu.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
World Health Organization, 2009. Fascioliasis: infection with the “neglected” neglected worms. Available at: http://www.who.int/neglected_diseases/integrated_media/integrated_media_fascioliasis/en/index.html. Accessed June 4, 2011.
-
2.
Mas-Coma S, Valero MA, Bargues MD, 2009. Chapter 2: Fasciola, lymnaeids, and human fascioliasis, with a global overview of disease transmission, epidemiology, evolutionary genetics, molecular epidemiology, and control. Adv Parasitol 69: 41– 146.
-
3.
Mas-Coma MS, Esteban JG, Bargues MD, 1999. Epidemiology of human fascioliasis: a review and proposed new classification. Bull World Health Organ 77: 340– 346.
-
4.
Marcos LA, Tagle M, Terashima A, Bussalleu A, Ramirez C, Carrasco C, Valdez L, Huerta-Mercado J, Freedman DO, Vinetz JM, Gotuzzo E, 2008. Natural history, clinicoradiologic correlates, and response to triclabendazole in acute massive fascioliasis. Am J Trop Med Hyg 78: 222– 227.
-
5.
Blancas G, Terashima A, Maguina C, Vera L, Alvarez H, Tello R, 2004. Human fascioliasis and gastrointestinal involvement: review of 277 cases seen between 1970 and 2002 at Hospital Nacional Cayetano Heredia. Rev Gastroenterol Peru 24: 143– 157.
-
6.
Marcos LA, Maco V, Castillo M, Terashima A, Zerpa R, Gotuzzo E, 2005. Case series of fascioliasis seen between 1988 and 2003 at Instituto Especializado de Salud del Niño, Lima-Peru. Rev Gastroenterol Peru 25: 198– 205.
-
7.
Marcos LA, Terashima A, Leguia G, Canales M, Espinoza JR, Gotuzzo E, 2007. Fasciola hepatica infection in Peru: an emerging disease. Rev Gastroenterol Peru 27: 389– 396.
-
8.
Marcos LA, Maco V, Terashima A, Samalvides F, Gotuzzo E, 2002. Clinical characteristics of Fasciola hepatica infection in children. Rev Gastroenterol Peru 22: 228– 233.
-
9.
Madan N, Rusia U, Sikka M, Sharma S, Shankar N, 2011. Developmental and neurophysiologic deficits in iron deficiency children. Indian J Pediatr 78: 58– 64.
-
10.
Marcos LA, Yi P, Machicado A, Andrade R, Samalvides F, Sanchez J, Terashima A, 2007. Hepatic fibrosis and Fasciola hepatica infection in cattle. J Helminthol 81: 381– 386.
-
11.
Marcos LA, Bussalleu A, Terashima A, Espinoza JR, 2009. Detection of antibodies against Fasciola hepatica in cirrhotic patients from Peru. Helminthol 83: 23– 26.
-
12.
Maco-Flores V, Marcos-Raymundo L, Terashima-Iwashita A, Samalvides-Cuba F, Miranda-Sanchez E, Espinoza-Babilon J, Gotuzzo-Herencia E, 2002. Fas-2 ELISA and the rapid sedimentation technique modified by Lumbreras for Fasciola hepatica infection diagnosis. Rev Med Hered 13: 49– 57.
-
13.
Terashima A, Marcos L, Maco V, Canales M, Samalvides F, Tello R, 2009. Highly sensitive in test tube sedimentation technique for the diagnosis of intestinal parasites. Rev Gastroenterol Peru 29: 305– 310.
-
14.
Nestel P, 2002. Adjusting Hemoglobin Values in Program Surveys. For the International Nutritional Anemia Consultative Group. Available at: http://pdf.usaid.gov/pdf_docs/PNACQ927.pdf. Accessed June 2, 2011.
-
15.
Dirren H, Logman MH, Barclay DV, Freire WB, 1994. Altitude correction for hemoglobin. Eur J Clin Nutr 48: 625– 632.
-
16.
World Health Organization, 2001. Iron Deficiency Anaemia Assessment, Prevention and Control: A Guide for Programme Managers. Available at: http://www.who.int/nutrition/publications/en/ida_assessment_prevention_control.pdf. Accessed June 4, 2011.
-
17.
De Onis M, Onyango AW, Borghi E, Siyam A, Nishida C, Siekmann J, 2007. Development of a WHO growth reference for school-aged children and adolescents. Bull World Health Organ 85: 660– 667.
-
18.
World Health Organization, 2011. Application Tools: WHO AnthroPlus Manual. Available at: http://www.who.int/growthref/tools/en/. Accessed June 4, 2011.
-
19.
Zevallos K, Vergara KC, Vergara A, Vidal C, Garcia HH, Evans CA, 2010. Tuberculin skin-test reactions are unaffected by the severity of hyperendemic intestinal helminth infections and co-infections. Am J Trop Med Hyg 83: 319– 325.
-
20.
Maco-Flores V, Marcos-Raymundo LA, Terashima-Iwashita A, Samalvides-Cuba F, Gotuzzo-Herencia E, 2002. Distribution of enteric parasites in the Peruvian Altiplano: a study in 6 communities in Puno, Peru. Rev Gastroenterol Peru 22: 304– 309.
-
21.
Cabrera M, Verastegui M, Cabrera R, 2005. Prevalence of enteric parasites in a highland community of the Victor Fajardo Province, Ayacucho, Peru. Rev Gastroenterol Peru 25: 150– 155.
-
22.
INEI, 2010. Peruvian Poverty Map by Province and District 2009: Focused on Income. Available at: http://www.unfpa.org.pe/publicaciones/publicacionesperu/INEI-Mapa-Pobreza-2009. Accessed June 4, 2011.
-
23.
Ngui R, Ishak S, Chuen CS, Mahmud R, Lim YA, 2011. Prevalence and risk factors of intestinal parasitism in rural and remote west Malaysia. PLoS Negl Trop Dis 5: e974.
-
24.
Quihui I, Valencia ME, Cromptom DW, Phillips S, Hagan P, Morales G, Diaz-Camacho SP, 2006. Role of the employment status and education of mothers in the prevalence of intestinal parasitic infections in Mexican rural schoolchildren. BMC Public Health 6: 225.
-
25.
Marcos LA, Terashima A, Gotuzzo E, 2008. Update on hepatobiliary flukes: fascioliasis, opisthorchiasis, and clonorchiasis. Curr Opin Infect Dis 21: 523– 530.
-
26.
Mas-Coma S, Angles R, Esteban JG, Bargues MD, Buchon P, Franken M, Strauss W, 1999. The northern Bolivian Altiplano: a region highly endemic for human fascioliasis. Trop Med Int Health 4: 454– 467.
-
27.
Marcos L, Romani L, Florencio L, Terashima A, Canales M, Nestares J, Huayanay L, Gotuzzo E, 2007. Hyperendemic and mesoendemic areas for Fasciola hepatica infection near Lima: an emerging illness? Rev Gastroenterol Peru 27: 21– 26.
-
28.
Parkinson M, O'Neill SM, Dalton JP, 2007. Endemic human fascioliosis in the Bolivian Altiplano. Epidemiol Infect 135: 669– 674.
-
29.
Marcos L, Maco V, Samalvides F, Terashima A, Espinoza JR, Gotuzzo E, 2006. Risk factors for Fasciola hepatica infection in children: a case-control study. Trans R Soc Trop Med Hyg 100: 158– 166.
-
30.
Mas-Coma S, Funatsu IR, Bargues MD, 2001. Fasciola hepatica and lymnaeid snails occurring at very high altitude in South America. Parasitology 123: S115– S127.
-
31.
Grantham-McGregor S, Cheung YB, Cueto S, Glewwe P, Richter L, Strupp B; International Child Development Steering Group, 2007. Child development in developing countries 1: developmental potential in the first 5 years for children in developing countries. Lancet 369: 60– 70.
-
32.
Gyorkos TW, Maheu-Giroux M, Casapia M, Joseph SA, Creed-Kanashiro H, 2011. Stunting and helminths infection in early preschool-age children in a resource-poor community in the Amazon lowlands of Peru. Trans R Soc Trop Med Hyg 105: 204– 208.
-
33.
Casapia M, Joseph SA, Nunez C, Rahme E, Gyorkos TW, 2006. Parasite risk factors for stunting in grade 5 students in a community of extreme poverty in Peru. Int J Parasitol 36: 741– 747.
-
34.
King CH, 2010. Health metrics for helminth infections. Adv Parasitol 73: 51– 69.
-
35.
El-Shazly AM, El-Nahas HA, Abdel-Mageed AA, El Beshbishi SN, Azab MS, El Hasan MA, Arafa WA, Morsy TA, 2005. Human fascioliasis and aneamia in Dakahlia governorate, Egypt. J Egypt Soc Parasitol 35: 421– 432.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1341 | 1184 | 433 |
| Full Text Views | 700 | 4 | 0 |
| PDF Downloads | 222 | 5 | 0 |