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Efficacy of Artemether-Lumefantrine in Area of High Malaria Endemicity in India and Its Correlation with Blood Concentration of Lumefantrine

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  • National Institute of Malaria Research, Dwarka, Delhi, India; National Institute of Malaria Research, Rourkela, Orissa, India; Dalarna University College, Borlange, Sweden; Global Malaria Programme, World Health Organization, Geneva, Switzerland

This study was conducted to correlate blood concentrations of lumefantrine with treatment outcome for patients with Plasmodium falciparum malaria when the drug was given without specific instructions for administration with food. Patients with P. falciparum malaria in the highly endemic state of Orissa, India, were enrolled during 2008 and followed-up for 28 days after admistration of artemether-lumefantrine for three days according to a World Health Organization protocol. Drug concentration in whole blood was determined by using blood spots placed on filter paper on day 7. The technology is suitable for field studies. One hundred percent of the patients had an adequate clinical and parasitological response. These results confirm the efficacy of artemether-lumefantrine in persons from poor tribal communities when given without specific instructions regarding co-administration with food, despite high inter-individual variability in blood concentrations of lumefantrine.

Author Notes

*Address correspondence to Neena Valecha, National Institute of Malaria Research, Indian Council of Medical Research, Sector 8, Dwarka, New Delhi 110057, India. E-mail: neenavalecha@gmail.com

Authors' addresses: Neena Valecha and Prakriti Srivastava, National Institute of Malaria Research, Indian Council of Medical Research, Sector 8, Dwarka, New Delhi 110077, India, E-mails: neenavalecha@gmail.com and srivastavaprakriti@rediffmail.com. Suman Mohanty, Desert Medicine Research Centre, Indian Council of Medical Research, New Pali Road, Jodhpur, Rajasthan 342005, India, E-mail: ssnimr@gmail.com. Surya Sharma and Prajesh Tyagi, National Institute of Malaria Research, Sector 5, Rourkela, Orissa 769002, India, E-mails: suryaksharma@gmail.com and mrcrkl@dataone.in. Yngve Bergqvist, School of Health and Social Studies, Dalarna University College, S-781 88 Borlänge, Sweden, E-mail: ybq@du.se. Pascal Ringwald, Antimalarial Drug Resistance, Global Malaria Programme, World Health Organization, 20Av. Appia, 1211 Geneva 27, Switzerland, E-mail: ringwaldp@who.int.

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