• 1.

    Gugnani HC, 2000. Histoplasmosis in Africa: a review. Indian J Chest Dis Allied Sci 42: 271277.

  • 2.

    Nethercott JR, Schachter RK, Givan KE, Ryder DE, 1978. Histoplasmosis due to Histoplasma capsulatum var. duboisii in a Canadian immigrant. Arch Dermatol 114: 595598.

    • Search Google Scholar
    • Export Citation
  • 3.

    Loulergue P, Bastides F, Baudouin V, Chandenier J, Mariani-Kurkdjian P, Dupont B, Viard J-P, Dromer F, Lortholary O, 2007. Literature review and case histories of Histoplasma capsulatum var. duboisii infections in HIV-infected patients. Emerg Infect Dis 13: 16471652.

    • Search Google Scholar
    • Export Citation
  • 4.

    Buitrago MJ, Berenguer J, Mellado E, Rodríguez-Tudela JL, Cuenca-Estrella M, 2006. Detection of imported histoplasmosis in serum of HIV-infected patients using a real-time PCR-based assay. Eur J Clin Microbiol Infect Dis 10: 665668.

    • Search Google Scholar
    • Export Citation
  • 5.

    Dubois A, Janssens PG, Brutsaert P, Vanbreuseghem R, 1952. A case of African histoplasmosis; with a mycological note on Histoplasma duboisii n. sp. [in French, Un cas d? histoplasmose africaine. Avec une note mycologique sur Histoplasma duboisii n. sp.]. Ann Soc Belge Med Trop 32: 569584.

    • Search Google Scholar
    • Export Citation
  • 6.

    Gugnani HC, Muotoe-Okafor F, 1997. African histoplasmosis: a review. Rev Iberoam Micol 14: 155159.

  • 7.

    Zarnowski R, Miyazaki M, Dobrzyn A, Ntambi JM, Woods JP, 2007. Typing of Histoplasma capsulatum strains by fatty acid profile analysis. J Med Microbiol 56: 788797.

    • Search Google Scholar
    • Export Citation
  • 8.

    Minta DK, Dembélé M, Lorre G, Diallo DA, Traoré HA, Chabasse D, 2005. African histoplasmosis (Histoplasma capsulatum var. duboisii): a case report from Mali [in French, Histoplasmose Africaine à Histoplasma capsulatum var. duboisii. A propos d? un cas au Mali]. Cahiers Santé 15: 195199.

    • Search Google Scholar
    • Export Citation
  • 9.

    Binford CH, Dooley JR, 1976. African histoplasmosis. Binford CH, Connor DH, eds. Pathology of Tropical and Extraordinary Diseases. Volume 2.: Washington DC: Armed Forces Institute of Pathology, 581583.

    • Search Google Scholar
    • Export Citation
  • 10.

    Mudawi HM, Elamin EM, Baraka OZ, El-Hassan AM, 2008. Addison’s disease due to Histoplasma duboisii infection of the adrenal glands. Saudi Med J 29: 904906.

    • Search Google Scholar
    • Export Citation
  • 11.

    Sanguino JC, Rodrigues B, Baptista A, Quina M, 1996. Focal lesion of African histoplasmosis presenting as a malignant gastric ulcer. Hepatogastroenterology 43: 771775.

    • Search Google Scholar
    • Export Citation
  • 12.

    Pequignot H, Abelanet R, Christoforov B, Drouhet E, Duflo B, Gorin JP, Lapierre J, de Saint-Maur P, Tran-Vinh-Hien, 1972. Peritonitis due to perforation of intestinal histoplasmosis due to Histoplasma duboisii [in French, Péritonite par perforation d?une histoplasmose intestinale à Histoplasma duboisii]. Ann Med Interne (Paris) 123: 981986.

    • Search Google Scholar
    • Export Citation
  • 13.

    Khalil M, Iwatt AR, Gugnani HC, 1989. African histoplasmosis masquerading as carcinoma of the colon: report of a case and review of the literature. Dis Colon Rectum 32: 518520.

    • Search Google Scholar
    • Export Citation
  • 14.

    Bansal RK, Suseelan AV, Gugnani HC, 1977. Orbital cyst due to Histoplasma duboisii. Br J Ophthalmol 61: 7071.

  • 15.

    Weedon D, 2010. Mycoses and algal infections. Weedon’s Skin Pathology. Third edition. Churchill Livingstone Elsevier, 581606.

  • 16.

    McKee PH, Calonje E, Grayson W, 2005. Infectious diseases of the skin. McKee PH, Calonje E, Granter SR, eds. Pathology of the Skin with Clinical Correlations. Volume 1, Third edition. Philadephia, PA: Elsevier Mosby, 837992.

    • Search Google Scholar
    • Export Citation
  • 17.

    Chandler FW, Kaplan W, Ajello L, 1980. Histoplasmosis duboisii. A Colour Atlas and Textbook of the Histopathology of Mycotic Diseases. London: Wolfe Medical Publications Ltd., 6769.

    • Search Google Scholar
    • Export Citation
  • 18.

    Prieto-Granada CN, Lobo AZC, Mihm MC Jr, 2010. Skin infections. Kradin RL, ed. Diagnostic Pathology of Infectious Disease. Saunders Elsevier, 519616.

    • Search Google Scholar
    • Export Citation
  • 19.

    White CL, 2008. Immunohistochemistry applications in pathology. Bancroft JD, Gamble M, eds. Theory and Practice of Histological Techniques. Sixth edition. Churchill Livingstone Elsevier, 493516.

    • Search Google Scholar
    • Export Citation
  • 20.

    Oguachuba HN, Gugnani HC, 1982. African histoplasmosis manifesting as a cutaneous tumour treated with econazole. J Trop Med Hyg 85: 259263.

    • Search Google Scholar
    • Export Citation
  • 21.

    Wheat LJ, Freifeld AG, Kleiman MB, Baddley JW, McKinsey DS, Loyd JE, Kauffman CA, 2007. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis 45: 807825.

    • Search Google Scholar
    • Export Citation
Past two years Past Year Past 30 Days
Abstract Views 0 0 0
Full Text Views 318 153 3
PDF Downloads 104 70 3
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 
 

 

 

 

An Unusual Cutaneous Tumor: African Histoplasmosis following Mudbaths: Case Report and Review

View More View Less
  • 4th Department of Internal Medicine, “Attikon” University Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece; Plastic surgery practice, Rhodes, Greece; Mycology Reference Laboratory, National Centre of Microbiology, Istituto de Salud Carlos III, Madrid, Spain; 2nd Department of Pathology, “Attikon” University Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece
Restricted access

African histoplasmosis, caused by Histoplasma capsulatum var. duboisii, is endemic in Africa. The disease usually involves the skin, subcutaneous tissue, and bones. A case of African histoplasmosis presenting as a cutaneous tumor and non-healing wound in a 66-year-old immunocompetent male residing in Africa, the first ever reported following mudbaths and acupuncture, is hereby reported. Diagnosis was confirmed by means of polymerase chain reaction performed on tissue material. The patient was started on long-term itraconazole therapy and he responded well. African histoplasmosis should be included in the differential diagnosis of non-healing wounds or tumor-like lesions, especially in the context of mudbaths in an endemic area.

Author Notes

*Address correspondence to Sotirios Tsiodras, 4th Department of Internal Medicine, “Attikon” University Hospital, National and Kapodistrian University of Athens School of Medicine, 1 Rimini Street, GR-12462 Haidari, Athens, Greece. E-mail: tsiodras@med.uoa.gr

Authors’ addresses: Sotirios Tsiodras, Miranda Drogari-Apiranthitou, Konstantinos Leventakos, Theodoros Kelesidis, and Georgios Petrikkos, 4th Department of Internal Medicine, “Attikon” University Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece, E-mails: tsiodras@med.uoa.gr, mdrogari@hotmail.com, kostasleventakos@gmail.com, tkelesid@gmail.com, and petrikos@med.uoa.gr. Konstantinos Pilichos, Plastic Surgery Practice, Rhodes, Dodecanese, Greece, E-mail: kpilplast@yahoo.gr. Maria Jose Buitrago Serna, Mycology Reference Laboratory, National Centre of Microbiology, Istituto de Salud Carlos III, Madrid, Spain, E-mail: buitrago@isciii.es. Ioannis Panayiotides, 2nd Department of Pathology, ?Attikon? University Hospital, National and Kapodistrian University of Athens School of Medicine, Athens, Greece, E-mail: ioagpan@gmail.com.

Save