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-
1.
Gottesman G, Vanunu D, Maayan MC, Lang R, Uziel Y, Sagi H, Wolach B, 1996. Childhood brucellosis in Israel. Pediatr Infect Dis J 15: 610–615.
-
2.
Omar FZ, Zuberi S, Minns RA, 1997. Neurobrucellosis in childhood: six new cases and a review of the literature. Dev Med Child Neurol 39: 762–765.
-
3.
Mantur BG, Akki AS, Mangalgi SS, Patil SV, Gobbur RH, Peerapur BV, 2004. Childhood brucellosis–a microbiological, epidemiological and clinical study. J Trop Pediatr 50: 153–157.
-
4.
Colmenero JD, Reguera JM, Martos F, Sanchez-De-Mora D, Delgado M, Causse M, Martin-Farfan A, Juarez C, 1996. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 75: 195–211.
-
5.
Lubani MM, Dudin KI, Araj GF, Manandhar DS, Rashid FY, 1989. Neurobrucellosis in children. Pediatr Infect Dis J 8: 79–82.
-
6.
Habeeb YK, Al-Najdi AK, Sadek SA, Al-Onaizi E, 1998. Pediatric neurobrucellosis: case report and literature review. J Infect 37: 59–62.
-
7.
Shakir RA, Al-Din AS, Araj GF, Lulu AR, Mousa AR, Saadah MA, 1987. Clinical categories of neurobrucellosis. A report on 19 cases. Brain 110: 213–223.
-
8.
Romero C, Gamazo C, Pardo M, Lopez-Goni I, 1995. Specific detection of Brucella DNA by PCR. J Clin Microbiol 33: 615–617.
-
9.
Araj GF, 2010. Update on laboratory diagnosis of human brucellosis. Int J Antimicrob Agents 36: (Suppl 1) S12–S17.
-
10.
Bouza E, Garcia de la Torre M, Parras F, Guerrero A, Rodriguez-Creixems M, Gobernado J, 1987. Brucellar meningitis. Rev Infect Dis 9: 810–822.
-
11.
Pascual J, Combarros O, Polo JM, Berciano J, 1988. Localized CNS brucellosis: report of 7 cases. Acta Neurol Scand 78: 282–289.
-
12.
Colmenero JD, Queipo-Ortuno MI, Reguera JM, Baeza G, Salazar JA, Morata P, 2005. Real time polymerase chain reaction: a new powerful tool for the diagnosis of neurobrucellosis. J Neurol Neurosurg Psychiatry 76: 1025–1027.
-
13.
Miguel PS, Fernandez G, Vasallo FJ, Hortas M, Lorenzo JR, Rodriguez I, Ortiz-Rey JA, Anton I, 2006. Neurobrucellosis mimicking cerebral tumor: case report and literature review. Clin Neurol Neurosurg 108: 404–406.
-
14.
American Academy of Pediatrics, 2009. Brucellosis. Pickering LK, Baker CJ, Kimberlin DW, Long SS, eds. Red Book: 2009 Report of the Committee of Infectious Diseases. 28th edition. Elk Grove Village, IL: American Academy of Pediatrics, 237–239.
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Unusual Presentations of Pediatric Neurobrucellosis
Isolda Budnik
Isolda Budnik
Pediatric Infectious Disease Unit, Department of Radiology, Pediatrics Department, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Inbal Fuchs
Inbal Fuchs
Pediatric Infectious Disease Unit, Department of Radiology, Pediatrics Department, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Ilan Shelef
Ilan Shelef
Pediatric Infectious Disease Unit, Department of Radiology, Pediatrics Department, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Hana Krymko
Hana Krymko
Pediatric Infectious Disease Unit, Department of Radiology, Pediatrics Department, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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David Greenberg
David Greenberg
Pediatric Infectious Disease Unit, Department of Radiology, Pediatrics Department, Soroka University Medical Center and the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel
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Neurobrucellosis is an uncommon complication of pediatric brucellosis. Acute meningitis and encephalitis are the most common clinical manifestations, however symptoms may be protean and diagnosis requires a high index of suspicion in patients from endemic areas. Diagnosis is often based on neurological symptoms, serology, and suggestive brain imaging because cerebrospinal fluid culture yields are low. Two cases of pediatric neurobrucellosis with unusual clinical and radiologic findings are presented.
Author Notes
Authors' addresses: Isolda Budnik and David Greenberg, Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, Israel, E-mails: isolbudnik@gmail.com and dudi@bgu.ac.il. Inbal Fuchs, Pediatric Infectious Disease Unit, Soroka University Medical Center, Beer-Sheva, Israel, E-mail: fuksen@bgu.ac.il. Ilan Shelef, The Department of Radiology, Soroka University Medical Center, Beer-Sheva, Israel, E-mail: IlanS@clalit.org.il. Hana Krymko, The Pediatrics Department, Soroka University Medical Center, Beer-Sheva, Israel, E-mail: HanaKr@clalit.org.il.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Gottesman G, Vanunu D, Maayan MC, Lang R, Uziel Y, Sagi H, Wolach B, 1996. Childhood brucellosis in Israel. Pediatr Infect Dis J 15: 610–615.
-
2.
Omar FZ, Zuberi S, Minns RA, 1997. Neurobrucellosis in childhood: six new cases and a review of the literature. Dev Med Child Neurol 39: 762–765.
-
3.
Mantur BG, Akki AS, Mangalgi SS, Patil SV, Gobbur RH, Peerapur BV, 2004. Childhood brucellosis–a microbiological, epidemiological and clinical study. J Trop Pediatr 50: 153–157.
-
4.
Colmenero JD, Reguera JM, Martos F, Sanchez-De-Mora D, Delgado M, Causse M, Martin-Farfan A, Juarez C, 1996. Complications associated with Brucella melitensis infection: a study of 530 cases. Medicine (Baltimore) 75: 195–211.
-
5.
Lubani MM, Dudin KI, Araj GF, Manandhar DS, Rashid FY, 1989. Neurobrucellosis in children. Pediatr Infect Dis J 8: 79–82.
-
6.
Habeeb YK, Al-Najdi AK, Sadek SA, Al-Onaizi E, 1998. Pediatric neurobrucellosis: case report and literature review. J Infect 37: 59–62.
-
7.
Shakir RA, Al-Din AS, Araj GF, Lulu AR, Mousa AR, Saadah MA, 1987. Clinical categories of neurobrucellosis. A report on 19 cases. Brain 110: 213–223.
-
8.
Romero C, Gamazo C, Pardo M, Lopez-Goni I, 1995. Specific detection of Brucella DNA by PCR. J Clin Microbiol 33: 615–617.
-
9.
Araj GF, 2010. Update on laboratory diagnosis of human brucellosis. Int J Antimicrob Agents 36: (Suppl 1) S12–S17.
-
10.
Bouza E, Garcia de la Torre M, Parras F, Guerrero A, Rodriguez-Creixems M, Gobernado J, 1987. Brucellar meningitis. Rev Infect Dis 9: 810–822.
-
11.
Pascual J, Combarros O, Polo JM, Berciano J, 1988. Localized CNS brucellosis: report of 7 cases. Acta Neurol Scand 78: 282–289.
-
12.
Colmenero JD, Queipo-Ortuno MI, Reguera JM, Baeza G, Salazar JA, Morata P, 2005. Real time polymerase chain reaction: a new powerful tool for the diagnosis of neurobrucellosis. J Neurol Neurosurg Psychiatry 76: 1025–1027.
-
13.
Miguel PS, Fernandez G, Vasallo FJ, Hortas M, Lorenzo JR, Rodriguez I, Ortiz-Rey JA, Anton I, 2006. Neurobrucellosis mimicking cerebral tumor: case report and literature review. Clin Neurol Neurosurg 108: 404–406.
-
14.
American Academy of Pediatrics, 2009. Brucellosis. Pickering LK, Baker CJ, Kimberlin DW, Long SS, eds. Red Book: 2009 Report of the Committee of Infectious Diseases. 28th edition. Elk Grove Village, IL: American Academy of Pediatrics, 237–239.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1450 | 1359 | 19 |
| Full Text Views | 319 | 1 | 0 |
| PDF Downloads | 111 | 2 | 0 |