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The Emergence of Rotavirus G12 and the Prevalence of Enteric Viruses in Hospitalized Pediatric Diarrheal Patients in Southern Vietnam

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  • Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam; Center for Infectious Disease Dynamics, Department of Biology, Pennsylvania State University, University Park, Pennsylvania; Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam; Fogarty International Center, National Institutes of Health, Bethesda, Maryland; Dong Thap Provincial Hospital, Dong Thap, Vietnam; Centre for Tropical Diseases, University of Oxford, Oxford, United Kingdom

Diarrhea is a major cause of childhood morbidity and mortality in developing countries, and the majority of infections are of viral etiology. We aimed to compare the etiological prevalence of the major enteric viruses in an urban and a rural setting in southern Vietnam. We simultaneously screened fecal specimens from 362 children in Ho Chi Minh City and Dong Thap province that were hospitalized with acute diarrhea over a 1-month-long period for four viral gastrointestinal pathogens. Rotavirus was the most common pathogen identified, but there was a differential prevalence of rotavirus and norovirus between the urban and rural locations. Furthermore, rotavirus genotyping and phylogenetic analysis again differentiated the genotypes by the sampling location. Our data show a disproportional distribution of enteric viral pathogens in urban and rural locations, and we provide evidence of continual importation of new rotavirus strains into southern Vietnam and report the emergence of rotavirus genotype G12.

Author Notes

*Address correspondence to Stephen Baker, Enteric Infections Group, Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, 190 Ben Ham Tu, District 5, Ho Chi Minh City, Vietnam. E-mail: sbaker@oucru.org

Financial support: This work is supported by The Wellcome Trust, Euston Road, London, United Kingdom. S.B. is supported by an Oak Foundation Fellowship through Oxford University. M.A.R. is supported by a National Science Foundation Graduate Research Fellowship.

Authors' addresses: Phan Vu Tra My, Nguyen Van Minh Hoang, Nguyen Thanh Vinh, James I. Campbell, Jeremy Farrar, and Stephen Baker, Enteric Infections Group, Hospital for Tropical Diseases, Wellcome Trust Major Overseas Programme, Oxford University Clinical Research Unit, Ho Chi Minh City, Vietnam, E-mails: mypvt@oucru.org, hoangnvm@oucru.org, vinhnt@oucru.org, jcampbell@oucru.org, jfarrar@oucru.org, and sbaker@oucru.org. Maia A. Rabaa, Department of Biology, Center for Infectious Disease Dynamics, Pennsylvania State University, University Park, PA, E-mail: maia.rabaa@gmail.com. Ha Vinh, Pediatric Ward B, Hospital for Tropical Diseases, Ho Chi Minh City, Vietnam, E-mail: vinhh@oucru.org. Edward C. Holmes, Fogarty International Center, National Institute of Health, Bethesda, MD, E-mail: ech15@psu.edu. Le Thi Phuong, Nguyen Thi Tham, and Phan Van Be Bay, Infectious Ward, Dong Thap Provincial Hospital, Dong Thap, Vietnam.

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