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Quality of Life among Adults with Confirmed Dengue in Brazil

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  • Institute of Tropical Pathology and Public Health, Federal University of Goias, Goias, Brazil; Tropical Medicine Department, Federal University of Pernambuco, Recife, Pernambuco, Brazil; Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Recife, Pernambuco, Brazil; Schneider Institutes for Health Policy, Heller School, Brandeis University, Waltham, Massachusetts

The main objective of this study was to measure the quality of life (QoL) during a dengue episode. We conducted a facility-based survey in central Brazil in 2005 and recruited 372 laboratory-confirmed dengue patients greater than 12 years of age in hospital and ambulatory settings. We administered the World Health Organization QoL instrument approximately 15 days after the onset of symptoms. We used principal component analysis with varimax rotation to identify domains related to QoL. The median age of interviewees was 36 years. Most (85%) reported their general health status as very good or good before the dengue episode. Although ambulatory patients were mainly classified as having dengue fever, 44.8% of hospitalized patients had dengue hemorrhagic fever or intermediate dengue. Principal component analysis identified five principal components related to cognition, sleep and energy, mobility, self-care, pain, and discomfort, which explained 73% of the variability of the data matrix. Hospitalized patients had significantly lower mean scores for dimensions cognition, self-care, and pain than ambulatory patients. This investigation documented the generally poor QoL during a dengue episode caused by the large number of domains affected and significant differences between health care settings.

Author Notes

*Address correspondence to Celina Maria Turchi Martelli, Tropical Medicine Department, Federal University of Pernambuco, Rua Professor Moraes Rego, Hospital das Clinicas, CEP 50670-901, Recife, Pernambuco, Brazil. E-mail: celina@pq.cnpq.br

Financial support: This study was supported by the Pediatric Dengue Vaccine Initiative and the institutions of the authors. Celina Maria Turchi Martelli, Wayner Vieira Souza, and Marilia Dalva Turchi received research scholarships (CNPq nos. 306489/2010-4, 305947/2006-0, and 306928/2010-8, respectively) and are research members of the National Institute of Science and Technology for Health Technology Assessment. Joao Borges Peres Jr. received a CNPq scholarship from the National Institute for Health Technology Assessment.

Authors' addresses: Celina Maria Turchi Martelli, Tropical Medicine Department, Federal University of Pernambuco, Rua Professor Moraes Rego, s/n. Hospital das Clinicas, Federal University of Goias, Cidade Universitária, Recife, Pernambuco, 50670-901 Brazil and Institute of Tropical Pathology and Public Health, Federal University of Goias, Rua 235 Esq. c/ 1a Avenida, s/n, Setor, Universitario, Goiania, Goias 74605-050 Brazil, E-mail: celina@pq.cnpq.br. Nazareth Elias Nascimento, Joao Bosco Siqueira Jr., Marilia Dalva Turchi, Adriana Oliveira Guilarde, and Joao Borges Peres Jr., Institute of Tropical Pathology and Public Health, Federal University of Goias, Rua 235 Esq. c/ 1a Avenida, s/n, Setor Universitario, Goiania, Goias 74605-050, Brazil. Jose A. Suaya and Donald S. Shepard, Schneider Institutes for Health Policy, The Heller School, Brandeis University, Waltham, MA. Wayner Vieira Souza, Aggeu Magalhães Research Center, Oswaldo Cruz Foundation, Av. Professor Moraes Rego, s/n - Campus da Federal University of Pernambuco, Cidade Universitária. Recife, Pernambuco 50.670-420, Brazil.

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