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Priming Effect of Dengue and Yellow Fever Vaccination on the Immunogenicity, Infectivity, and Safety of a Tetravalent Dengue Vaccine in Humans

Ming QiaoMicrobiology and Infectious Diseases, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Infectious Diseases Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Sanofi Pasteur, Lyon, France; Sanofi Pasteur, Thailand

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David ShawMicrobiology and Infectious Diseases, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Infectious Diseases Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Sanofi Pasteur, Lyon, France; Sanofi Pasteur, Thailand

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Remi ForratMicrobiology and Infectious Diseases, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Infectious Diseases Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Sanofi Pasteur, Lyon, France; Sanofi Pasteur, Thailand

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Anh Wartel-TramMicrobiology and Infectious Diseases, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Infectious Diseases Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Sanofi Pasteur, Lyon, France; Sanofi Pasteur, Thailand

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Jean LangMicrobiology and Infectious Diseases, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia; Infectious Diseases Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia; Sanofi Pasteur, Lyon, France; Sanofi Pasteur, Thailand

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A dengue vaccine effective against all four serotypes is urgently needed. However, safety and immunogenicity could be affected by prior exposure to flaviviruses. This open, controlled, phase IIa study was conducted in 35 healthy adults who had received monovalent, live attenuated Vero cell-derived dengue vaccine against dengue virus 1 (VDV1) or 2 (VDV2) or yellow fever (YF) vaccine 1 year before or who were flavivirus-naïve. All participants received one subcutaneous injection of tetravalent dengue vaccine (TDV) and were followed for 180 days. Previous vaccination did not increase reactogenicity, laboratory abnormalities, or incidence of vaccine viremia, but it did increase the neutralizing antibody response to dengue virus that persisted at day 180. There was no increase in YF antibodies in participants previously immunized with YF vaccine. Prior exposure to YF or monovalent dengue vaccines had no adverse effects on the safety or incidence of viremia associated with this TDV, but it increased immunogenicity.

Author Notes

*Address correspondence to Ming Qiao, Microbiology and Infectious Diseases, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia. E-mail: ming.qiao@health.sa.gov.au

Financial support: This study was supported by a grant from Sanofi Pasteur. Editorial assistance for the preparation of this manuscript was funded by Sanofi Pasteur.

Authors' addresses: Ming Qiao, Microbiology and Infectious Diseases, Institute of Medical and Veterinary Science, Adelaide, South Australia, Australia, E-mail: ming.qiao@health.sa.gov.au. David Shaw, Infectious Diseases Unit, Royal Adelaide Hospital, Adelaide, South Australia, Australia, E-mail: david.shaw@health.sa.gov.au. Remi Forrat and Jean Lang, Sanofi Pasteur, Lyon, France, E-mails: remi.forrat@sanofipasteur.com and jean.lang@sanofipasteur.com. Anh Wartel-Tram, Sanofi Pasteur, Thailand, E-mail: wartel-tram.anh@sanofipasteur.com.

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