The Appropriate Indicator Should be Used to Assess Treatment Failure in STH Infections

Antonio Montresor
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Dirk Engels
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Lester Chitsulo
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Albis Gabrielli
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Marco Albonico
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Lorenzo Savioli
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Patrick Lammie
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Author Notes

  • 1.

    Humphries D , Mosites E , Otchere J , Twum WA , Woo L , Jones-Sanpei H , Harrison LM , Bungiro RD , Benham-Pyle B , Bimi L , Edoh D , Bosompem K , Wilson M , Cappello M , 2011. Epidemiology of hookworm infection in Kintampo North Municipality, Ghana: patterns of malaria coinfection, anemia, and albendazole treatment failure. Am J Trop Med Hyg 84: 792–800.

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  • 2.

    Montresor A , 2011. Cure rate is not a valid indicator for assessing drug efficacy and impact of preventive chemotherapy interventions against schistosomiasis and soil-transmitted helminthiasis. Trans R Soc Trop Med Hyg 105: 361–363.

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  • 3.

    Vercruysse J , Behnke JM , Albonico M , Ame SM , Angebault C , Bethony JM , Guillard B , Nguyen TV , Kang G , Kattula D , Kotze AC , McCarthy JS , Mekonnen Z , Montresor A , Periago MV , Sumo L , Tchuenté LA , Zeynudin A , Levecke B , 2011. Assessment of the anthelmintic efficacy of albendazole in school children in seven countries where soil-transmitted helminths are endemic. PLoS Negl Trop Dis 5: e948.

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  • 4.

    WHO , 2002. Helminth Control in School-Age Children: A Guide for Managers of Control Programmes. Geneva: World Health Organization.

  • 5.

    Anderson RM , May RM , 1991. Infectious Diseases of Humans: Dynamics and Control. Oxford, UK: Oxford University Press.

  • 6.

    Crompton DW , Savioli L , 2006. Handbook of Helminthiasis for Public Health. Boca Raton, FL: CRC Press: Taylor & Francis Group.

  • 7.

    Keiser J , Utzinger J , 2008. Efficacy of current drugs against soil-transmitted helminth infections: systematic review and meta-analysis. JAMA 299: 1937–1948.

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  • 8.

    Flohr C , Tuyen LN , Lewis S , Quinnell R , Minh TT , Liem HT , Campbell J , Pritchard D , Hien TT , Farrar J , Williams H , Britton J , 2007. Low efficacy of mebendazole against hookworm in Vietnam: two randomized controlled trials. Am J Trop Med Hyg 76: 732–736.

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