ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Barsoum RS, 2004. Parasitic infections in organ transplantation. Exp Clin Transplant 2: 258–267.
-
2.
Nachbaur D, Kropshofer G, Feichtinger H, Allerberger F, Niederwieser D, 1997. Cryptosporidiosis after CD34-selected autologous peripheral blood stem cell transplantation (PBSCT). Treatment with paromomycin, azithromycin and recombinant human interleukin-2. Bone Marrow Transplant 19: 1261–1263.
-
3.
Raina V, Sharma A, Gujral S, Kumar R, 1998. Plasmodium vivax causing pancytopenia after allogeneic blood stem cell transplantation in CML. Bone Marrow Transplant 22: 205–206.
-
4.
Straathof CS, Kortbeek LM, Roerdink H, Sillevis Smitt PA, van den Bent MJ, 2001. A solitary spinal cord toxoplasma lesion after peripheral stem-cell transplantation. J Neurol 248: 814–815.
-
5.
Munoz P, Valerio M, Puga D, Bouza E, 2010. Parasitic infections in solid organ transplant recipients. Infect Dis Clin North Am 24: 461–495.
-
6.
Sra KK, Sracic J, Tyring SK, 2004. Treatment of protozoan infections. Dermatol Ther 17: 513–516.
-
7.
Boelaert M, Aoun K, Liinev J, Goetghebeur E, Van der Stuyft P, 1999. The potential of latent class analysis in diagnostic test validation for canine Leishmania infantum infection. Epidemiol Infect 123: 499–506.
-
8.
Ozcan D, Seckin D, Allahverdiyev AM, Weina PJ, Aydin H, Ozcay F, Haberal M, 2007. Liver transplant recipient with concomitant cutaneous and visceral leishmaniasis. Pediatr Transplant 11: 228–232.
-
9.
Garcia Menendez L, Santamaria Lopez C, Fernandez Eroles AL, Megido Lahera M, Galende del Canto J, Aguilera Sanz C, 1998. Monoclonal component in visceral leishmaniasis: a rare association that can lead to misdiagnosis. Rev Clin Esp 198: 517–520.
-
10.
Dujardin JC, Campino L, Canavate C, Dedet JP, Gradoni L, Soteriadou K, Mazeris A, Ozbel Y, Boelaert M, 2008. Spread of vector-borne diseases and neglect of leishmaniasis, Europe. Emerg Infect Dis 14: 1013–1018.
-
11.
Handman E, Bullen DV, 2002. Interaction of Leishmania with the host macrophage. Trends Parasitol 18: 332–334.
-
12.
Rittig MG, Bogdan C, 2000. Leishmania-host-cell interaction: complexities and alternative views. Parasitol Today 16: 292–297.
-
13.
Rebelatto CK, Aguiar AM, Moretao MP, Senegaglia AC, Hansen P, Barchiki F, Oliveira J, Martins J, Kuligovski C, Mansur F, Christofis A, Amaral VF, Brofman PS, Goldenberg S, Nakao LS, Correa A, 2008. Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue. Exp Biol Med (Maywood) 233: 901–913.
-
14.
Choi YS, Cha SM, Lee YY, Kwon SW, Park CJ, Kim M, 2006. Adipogenic differentiation of adipose tissue derived adult stem cells in nude mouse. Biochem Biophys Res Commun 345: 631–637.
-
15.
Shigemura N, Okumura M, Mizuno S, Imanishi Y, Nakamura T, Sawa Y, 2006. Autologous transplantation of adipose tissue-derived stromal cells ameliorates pulmonary emphysema. Am J Transplant 6: 2592–2600.
-
16.
Mazo M, Planat-Benard V, Abizanda G, Pelacho B, Leobon B, Gavira JJ, Penuelas I, Cemborain A, Penicaud L, Laharrague P, Joffre C, Boisson M, Ecay M, Collantes M, Barba J, Casteilla L, Prosper F, 2008. Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction. Eur J Heart Fail 10: 454–462.
-
17.
Allahverdiyev AM, Koc RC, Ates SC, Bagirova M, Elcicek S, Oztel ON, 2011. Leishmania tropica: the effect of darkness and light on biological activities in vitro. Exp Parasitol [Epub ahead of print].
-
18.
Merlen T, Sereno D, Brajon N, Rostand F, Lemesre JL, 1999. Leishmania spp.: completely defined medium without serum and macromolecules (CDM/LP) for the continuous in vitro cultivation of infective promastigote forms. Am J Trop Med Hyg 60: 41–50.
-
19.
Ma Y, Li Q, Zhao DQ, Wang SF, Li WZ, Min J, Gu Y, 2007. Isolation, cultivation of adipose-derived mesenchymal stem cells and its chondrogenic ability. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 23: 463–465.
-
20.
Ogawa R, Mizuno H, Watanabe A, Migita M, Hyakusoku H, Shimada T, 2004. Adipogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice-including relationship of sex differences. Biochem Biophys Res Commun 319: 511–517.
-
21.
Kroeze RJ, Knippenberg M, Helder MN, 2011. Osteogenic differentiation strategies for adipose-derived mesenchymal stem cells. Methods Mol Biol 702: 233–248.
-
22.
Mitchell JB, McIntosh K, Zvonic S, Garrett S, Floyd ZE, Kloster A, Di Halvorsen Y, Storms RW, Goh B, Kilroy G, Wu X, Gimble JM, 2006. Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers. Stem Cells 24: 376–385.
-
23.
Campos MB, De Castro Gomes CM, de Souza AA, Lainson R, Corbett CE, Silveira FT, 2008. In vitro infectivity of species of Leishmania (Viannia) responsible for American cutaneous leishmaniasis. Parasitol Res 103: 771–776.
-
24.
Chulay JD, Bryceson AD, 1983. Quantitation of amastigotes of Leishmania donovani in smears of splenic aspirates from patients with visceral leishmaniasis. Am J Trop Med Hyg 32: 475–479.
-
25.
Allahverdiyev AM, Bagirova M, Uzun S, Alabaz D, Aksaray N, Kocabas E, Koksal F, 2005. The value of a new microculture method for diagnosis of visceral leishmaniasis by using bone marrow and peripheral blood. Am J Trop Med Hyg 73: 276–280.
-
26.
Allahverdiyev AM, Uzun S, Bagirova M, Durdu M, Memisoglu HR, 2004. A sensitive new microculture method for diagnosis of cutaneous leishmaniasis. Am J Trop Med Hyg 70: 294–297.
-
27.
Serin MS, Daglioglu K, Bagirova M, Allahverdiyev A, Uzun S, Vural Z, Kayar B, Tezcan S, Yetkin M, Aslan G, Emekdas G, Koksal F, 2005. Rapid diagnosis and genotyping of Leishmania isolates from cutaneous and visceral leishmaniasis by microcapillary cultivation and polymerase chain reaction-restriction fragment length polymorphism of miniexon region. Diagn Microbiol Infect Dis 53: 209–214.
-
28.
Marques MJ, Volpini AC, Genaro O, Mayrink W, Romanha AJ, 2001. Simple form of clinical sample preservation and Leishmania DNA extraction from human lesions for diagnosis of American cutaneous leishmaniasis via polymerase chain reaction. Am J Trop Med Hyg 65: 902–906.
-
29.
Marfurt J, Nasereddin A, Niederwieser I, Jaffe CL, Beck HP, Felger I, 2003. Identification and differentiation of Leishmania species in clinical samples by PCR amplification of the miniexon sequence and subsequent restriction fragment length polymorphism analysis. J Clin Microbiol 41: 3147–3153.
-
30.
Bogdan C, Donhauser N, Doring R, Rollinghoff M, Diefenbach A, Rittig MG, 2000. Fibroblasts as host cells in latent leishmaniosis. J Exp Med 191: 2121–2130.
-
31.
Oren R, Schnur LF, Ben Yehuda D, Mayner V, Okon E, Rachmilewitz EA, 1991. Visceral leishmaniasis: a difficult diagnosis and unusual causative agent. J Infect Dis 164: 746–749.
-
32.
Cousin B, Munoz O, Andre M, Fontanilles AM, Dani C, Cousin JL, Laharrague P, Casteilla L, Penicaud L, 1999. A role for preadipocytes as macrophage-like cells. FASEB J 13: 305–312.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1540 | 1333 | 25 |
| Full Text Views | 379 | 14 | 2 |
| PDF Downloads | 119 | 14 | 1 |
Adipose Tissue-Derived Mesenchymal Stem Cells as a New Host Cell in Latent Leishmaniasis
Adil M. Allahverdiyev
Adil M. Allahverdiyev
Department of Bioengineering, Yildiz Technical University, Istanbul, Turkey; Department of Bioengineering, Firat University, Elazig, Turkey
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Melahat Bagirova
Melahat Bagirova
Department of Bioengineering, Yildiz Technical University, Istanbul, Turkey; Department of Bioengineering, Firat University, Elazig, Turkey
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Serhat Elcicek
Serhat Elcicek
Department of Bioengineering, Yildiz Technical University, Istanbul, Turkey; Department of Bioengineering, Firat University, Elazig, Turkey
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Rabia Cakir Koc
Rabia Cakir Koc
Department of Bioengineering, Yildiz Technical University, Istanbul, Turkey; Department of Bioengineering, Firat University, Elazig, Turkey
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Serap Yesilkir Baydar
Serap Yesilkir Baydar
Department of Bioengineering, Yildiz Technical University, Istanbul, Turkey; Department of Bioengineering, Firat University, Elazig, Turkey
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Necati Findikli
Necati Findikli
Department of Bioengineering, Yildiz Technical University, Istanbul, Turkey; Department of Bioengineering, Firat University, Elazig, Turkey
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Olga N. Oztel
Olga N. Oztel
Department of Bioengineering, Yildiz Technical University, Istanbul, Turkey; Department of Bioengineering, Firat University, Elazig, Turkey
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Some protozoan infections such as Toxoplasma, Cryptosporidium, and Plasmodium can be transmitted through stem cell transplantations. To our knowledge, so far, there is no study about transmission of Leishmania parasites in stem cell transplantation and interactions between parasites and stem cells in vitro. Therefore, the aim of this study was to investigate the interaction between different species of Leishmania parasites and adipose tissue-derived mesenchymal stem cells (ADMSCs). ADMSCs have been isolated, cultured, characterized, and infected with different species of Leishmania parasites (L. donovani, L. major, L. tropica, and L. infantum). Infectivity was examined by Giemsa staining, microculture, and polymerase chain reaction methods. As a result, infectivity of ADMSCs by Leishmania parasites has been determined for the first time in this study. According to our findings, it is very important that donors are screened for Leishmania parasites before stem cell transplantations in regions where leishmaniasis is endemic.
Author Notes
Authors' addresses: Adil M. Allahverdiyev, Melahat Bagirova, Rabia Cakir Koc, Serap Yesilkir Baydar, Necati Findikli, and Olga N. Oztel, Department of Bioengineering, Yildiz Technical University, Istanbul, Turkey, E-mails: adilmoglu@gmail.com, dr.melahatb@gmail.com, rabiacakir@gmail.com, serapoloji@gmail.com, necatif@gmail.com, and onoztel@gmail.com. Serhat Elcicek, Department of Bioengineering, Firat University, Elazig, Turkey, E-mail: serhatelcicek@gmail.com.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Barsoum RS, 2004. Parasitic infections in organ transplantation. Exp Clin Transplant 2: 258–267.
-
2.
Nachbaur D, Kropshofer G, Feichtinger H, Allerberger F, Niederwieser D, 1997. Cryptosporidiosis after CD34-selected autologous peripheral blood stem cell transplantation (PBSCT). Treatment with paromomycin, azithromycin and recombinant human interleukin-2. Bone Marrow Transplant 19: 1261–1263.
-
3.
Raina V, Sharma A, Gujral S, Kumar R, 1998. Plasmodium vivax causing pancytopenia after allogeneic blood stem cell transplantation in CML. Bone Marrow Transplant 22: 205–206.
-
4.
Straathof CS, Kortbeek LM, Roerdink H, Sillevis Smitt PA, van den Bent MJ, 2001. A solitary spinal cord toxoplasma lesion after peripheral stem-cell transplantation. J Neurol 248: 814–815.
-
5.
Munoz P, Valerio M, Puga D, Bouza E, 2010. Parasitic infections in solid organ transplant recipients. Infect Dis Clin North Am 24: 461–495.
-
6.
Sra KK, Sracic J, Tyring SK, 2004. Treatment of protozoan infections. Dermatol Ther 17: 513–516.
-
7.
Boelaert M, Aoun K, Liinev J, Goetghebeur E, Van der Stuyft P, 1999. The potential of latent class analysis in diagnostic test validation for canine Leishmania infantum infection. Epidemiol Infect 123: 499–506.
-
8.
Ozcan D, Seckin D, Allahverdiyev AM, Weina PJ, Aydin H, Ozcay F, Haberal M, 2007. Liver transplant recipient with concomitant cutaneous and visceral leishmaniasis. Pediatr Transplant 11: 228–232.
-
9.
Garcia Menendez L, Santamaria Lopez C, Fernandez Eroles AL, Megido Lahera M, Galende del Canto J, Aguilera Sanz C, 1998. Monoclonal component in visceral leishmaniasis: a rare association that can lead to misdiagnosis. Rev Clin Esp 198: 517–520.
-
10.
Dujardin JC, Campino L, Canavate C, Dedet JP, Gradoni L, Soteriadou K, Mazeris A, Ozbel Y, Boelaert M, 2008. Spread of vector-borne diseases and neglect of leishmaniasis, Europe. Emerg Infect Dis 14: 1013–1018.
-
11.
Handman E, Bullen DV, 2002. Interaction of Leishmania with the host macrophage. Trends Parasitol 18: 332–334.
-
12.
Rittig MG, Bogdan C, 2000. Leishmania-host-cell interaction: complexities and alternative views. Parasitol Today 16: 292–297.
-
13.
Rebelatto CK, Aguiar AM, Moretao MP, Senegaglia AC, Hansen P, Barchiki F, Oliveira J, Martins J, Kuligovski C, Mansur F, Christofis A, Amaral VF, Brofman PS, Goldenberg S, Nakao LS, Correa A, 2008. Dissimilar differentiation of mesenchymal stem cells from bone marrow, umbilical cord blood, and adipose tissue. Exp Biol Med (Maywood) 233: 901–913.
-
14.
Choi YS, Cha SM, Lee YY, Kwon SW, Park CJ, Kim M, 2006. Adipogenic differentiation of adipose tissue derived adult stem cells in nude mouse. Biochem Biophys Res Commun 345: 631–637.
-
15.
Shigemura N, Okumura M, Mizuno S, Imanishi Y, Nakamura T, Sawa Y, 2006. Autologous transplantation of adipose tissue-derived stromal cells ameliorates pulmonary emphysema. Am J Transplant 6: 2592–2600.
-
16.
Mazo M, Planat-Benard V, Abizanda G, Pelacho B, Leobon B, Gavira JJ, Penuelas I, Cemborain A, Penicaud L, Laharrague P, Joffre C, Boisson M, Ecay M, Collantes M, Barba J, Casteilla L, Prosper F, 2008. Transplantation of adipose derived stromal cells is associated with functional improvement in a rat model of chronic myocardial infarction. Eur J Heart Fail 10: 454–462.
-
17.
Allahverdiyev AM, Koc RC, Ates SC, Bagirova M, Elcicek S, Oztel ON, 2011. Leishmania tropica: the effect of darkness and light on biological activities in vitro. Exp Parasitol [Epub ahead of print].
-
18.
Merlen T, Sereno D, Brajon N, Rostand F, Lemesre JL, 1999. Leishmania spp.: completely defined medium without serum and macromolecules (CDM/LP) for the continuous in vitro cultivation of infective promastigote forms. Am J Trop Med Hyg 60: 41–50.
-
19.
Ma Y, Li Q, Zhao DQ, Wang SF, Li WZ, Min J, Gu Y, 2007. Isolation, cultivation of adipose-derived mesenchymal stem cells and its chondrogenic ability. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi 23: 463–465.
-
20.
Ogawa R, Mizuno H, Watanabe A, Migita M, Hyakusoku H, Shimada T, 2004. Adipogenic differentiation by adipose-derived stem cells harvested from GFP transgenic mice-including relationship of sex differences. Biochem Biophys Res Commun 319: 511–517.
-
21.
Kroeze RJ, Knippenberg M, Helder MN, 2011. Osteogenic differentiation strategies for adipose-derived mesenchymal stem cells. Methods Mol Biol 702: 233–248.
-
22.
Mitchell JB, McIntosh K, Zvonic S, Garrett S, Floyd ZE, Kloster A, Di Halvorsen Y, Storms RW, Goh B, Kilroy G, Wu X, Gimble JM, 2006. Immunophenotype of human adipose-derived cells: temporal changes in stromal-associated and stem cell-associated markers. Stem Cells 24: 376–385.
-
23.
Campos MB, De Castro Gomes CM, de Souza AA, Lainson R, Corbett CE, Silveira FT, 2008. In vitro infectivity of species of Leishmania (Viannia) responsible for American cutaneous leishmaniasis. Parasitol Res 103: 771–776.
-
24.
Chulay JD, Bryceson AD, 1983. Quantitation of amastigotes of Leishmania donovani in smears of splenic aspirates from patients with visceral leishmaniasis. Am J Trop Med Hyg 32: 475–479.
-
25.
Allahverdiyev AM, Bagirova M, Uzun S, Alabaz D, Aksaray N, Kocabas E, Koksal F, 2005. The value of a new microculture method for diagnosis of visceral leishmaniasis by using bone marrow and peripheral blood. Am J Trop Med Hyg 73: 276–280.
-
26.
Allahverdiyev AM, Uzun S, Bagirova M, Durdu M, Memisoglu HR, 2004. A sensitive new microculture method for diagnosis of cutaneous leishmaniasis. Am J Trop Med Hyg 70: 294–297.
-
27.
Serin MS, Daglioglu K, Bagirova M, Allahverdiyev A, Uzun S, Vural Z, Kayar B, Tezcan S, Yetkin M, Aslan G, Emekdas G, Koksal F, 2005. Rapid diagnosis and genotyping of Leishmania isolates from cutaneous and visceral leishmaniasis by microcapillary cultivation and polymerase chain reaction-restriction fragment length polymorphism of miniexon region. Diagn Microbiol Infect Dis 53: 209–214.
-
28.
Marques MJ, Volpini AC, Genaro O, Mayrink W, Romanha AJ, 2001. Simple form of clinical sample preservation and Leishmania DNA extraction from human lesions for diagnosis of American cutaneous leishmaniasis via polymerase chain reaction. Am J Trop Med Hyg 65: 902–906.
-
29.
Marfurt J, Nasereddin A, Niederwieser I, Jaffe CL, Beck HP, Felger I, 2003. Identification and differentiation of Leishmania species in clinical samples by PCR amplification of the miniexon sequence and subsequent restriction fragment length polymorphism analysis. J Clin Microbiol 41: 3147–3153.
-
30.
Bogdan C, Donhauser N, Doring R, Rollinghoff M, Diefenbach A, Rittig MG, 2000. Fibroblasts as host cells in latent leishmaniosis. J Exp Med 191: 2121–2130.
-
31.
Oren R, Schnur LF, Ben Yehuda D, Mayner V, Okon E, Rachmilewitz EA, 1991. Visceral leishmaniasis: a difficult diagnosis and unusual causative agent. J Infect Dis 164: 746–749.
-
32.
Cousin B, Munoz O, Andre M, Fontanilles AM, Dani C, Cousin JL, Laharrague P, Casteilla L, Penicaud L, 1999. A role for preadipocytes as macrophage-like cells. FASEB J 13: 305–312.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1540 | 1333 | 25 |
| Full Text Views | 379 | 14 | 2 |
| PDF Downloads | 119 | 14 | 1 |