Modi AA, Feld JJ, 2007. Viral hepatitis and HIV in Africa. AIDS Rev 9: 25ā39.
Kiire CF, 1996. The epidemiology and prophylaxis of Hepatitis B in sub-Saharan Africa: a view from tropical and subtropical Africa. Gut 38 (Suppl 2): S5āS12.
Opaleye OO, Zakariyahu TO, Tijani BA, Bakarey AS, 2010. HBV, HCV co-infection among blood donors in Nigeria. Indian J Pathol Microbiol 53: 182ā183.
Diarra A, Kouriba B, Baby M, Murphy E, Lefrere JJ, 2009. HIV, HCV, HBV and syphilis rate of positive donations among blood donations in Mali: lower rates among volunteer blood donors. Transfus Clin Biol 16: 444ā447.
Bwogi J, Braka F, Makumbi I, Mishra V, Bakamutumaho B, Nanyunja M, Opio A, Downing R, Biryahwaho B, Lewis R, 2009. Hepatitis B infection is highly endemic in Uganda: findings from a national serosurvey. Afr Health Sci 9: 98ā108.
Tagny C, Diarra A, Yahaya R, Hakizimana M, Nguessan A, Mbensa G, NĆ©biĆ© Y, Dahourou H, Mbanya D, Shiboski C, Murphy E, LefrĆØre J, 2009. Characteristics of blood donors and donated blood in sub-Saharan Francophone Africa. Transfusion 49: 1592ā1599.
Burnett R, Francois G, Kew M, Leroux-Roels G, Meheus A, Hoosen AA, Mphahlele MJ, 2005. Hepatitis B virus and human immunodeficiency virus co-infection in sub-Saharan Africa: a call for further investigation. Liver Int 25: 201ā213.
Nacro B, Dao B, Dahourour H, 2001. HBs antigen in children with suspicion of HIV infection. J Trop Pediatr 47: 303ā304.
Combe P, La Ruche G, Bonard D, Ouassa T, Faye-Kette H, Sylla-Koko F, Dabis F, 2001. Hepatitis B and C infections, human immunodeficiency virus and other sexually transmitted infections among women of childbearing age in Cote d'Ivoire, West Africa. Trans R Soc Trop Med Hyg 95: 493ā496.
Sutcliffe S, Taha TE, Kumwenda NI, Taylor E, Liomba GN, 2002. HIV-1 prevalence and herpes simplex virus 2, hepatitis C virus, and hepatitis B virus infections among male workers at a sugar estate in Malawi. J Acquir Immune Defic Syndr 95: 493ā496.
Adewole OO, Anteyi E, Ajuwon Z, Wada I, Elegba F, Ahmed P, Betiku Y, Okpe A, Eze S, Ogbeche T, Erhabor GE, 2009. Hepatitis B and C virus co-infection in Nigerian patients with HIV infection. J Infect Dev Ctries 3: 369ā375.
Nagu TJ, Bakari M, Matee M, 2008. Hepatitis A, B and C viral co-infections among HIV-infected adults presenting for care and treatment at Muhimbili National Hospital in Dar es Salaam, Tanzania. BMC Public Health 19: 416.
Kew MC, Kassianides C, Berger EL, Song E, Dusheiko GM, 1987. Prevalence of chronic hepatitis virus infection in pregnant women living in Soweto. J Med Virol 22: 263ā268.
Vos GH, Rose EF, Marimuthu T, 1984. Hepatitis B antigen and antibodies in rural and urban southern African blacks. S Afr J Med 57: 868ā870.
Lodenyo H, Schoup B, Ally R, Kairu S, Segal I, 2000. Hepatitis B and C virus infections and liver function in AIDS patients at Chris Hani Baragwanath Hospital, Johannesburg. East Afr Med J 77: 13ā15.
Firnhaber CS, Reyneke A, Schulze D, Malope B, Maskew M, Macphail P, Sanne I, Biscerglie A, 2008. The prevalence of hepatitis B co-infection in a South African urban government HIV clinic. S Afr Med J 98: 541ā544.
Wester W, Bussmann H, Moyo S, Avalos A, Gaolathe T, Ndwapi N, Essex M, MacGregor RR, Marlink R, 2006. Serological evidence of HIV-associated infection among HIV-1āinfected adults in Botswana. Clin Infect Dis 14: 1612ā1615.
Tedla Z, Nyirenda S, Peeler C, Agizew T, Sibanda T, Motsamai O, Vernon A, Wells CD, Samandari T, 2010. Isoniazid-associated hepatitis and antiretroviral drugs during tuberculosis prophylaxis in HIV-infected adults in Botswana. Am J Respir Crit Care Med 182: 278ā285.
Byskov AJS, Wouters M, Sathekge TJ, Swanepoel R, 1989. An outbreak of suspected water-borne epidemic non-A non-B hepatitis in northern Botswana with a high prevalence of hepatitis B carriers and hepatitis delta markers among patients. Trans R Soc Trop Med Hyg 83: 110ā116.
Mulwa JKM, 1994. Hepatitis B situation in Botswana. J Prev Med Hyg 35: 67.
Nurse GT, Tanaka N, MacNab G, Jenkins T, 1973. Non-venereal syphilis and Australia antigen among the G/Wi and G-Ana San of the Central Kalahari Reserve, Botswana. Cent Afr J Med 19: 10.
Dibisceglie AM, Kew MC, Dusheiko GM, Berger EL, Song E, Paterson AC, Hodkinson HJ, 1986. Prevalence of hepatitis B virus infection among black children in Soweto. Br Med J (Clin Res Ed) 292: 1440ā1442.
Madhava V, Burgess C, Drucker E, 2002. Epidemiology of chronic hepatitis C virus infection in sub-Saharan Africa. Lancet Infect Dis 2: 293ā302.
Kallestrup P, Zinyama R, Gomo E, 2003. Low prevalence of HCV antibodies in HIV-endemic area of Zimbabwe support sexual transmission as the major route of HIV transmission in Africa. AIDS 17: 1400ā1402.
Patel P, Davis S, Tolle M, Anabwani G, 2010. The Family Medical Clinic (FMC) at the Botswana-Baylor Children's Clinical Centre of Excellence (BBCCCOE) in Gaborone, BotswanaāA model of care. Proceedings of the 19th International AIDS Conference, July 18ā23, 2010; Vienna, Austria.
Aberg J, Kaplan J, Libman H, Emmanuel P, Anderson J, Stone V, Oleske J, Currier J, Gallant J, 2009. IDSA guidelines: primary care guidelines for the management of persons infected with human immunodeficiency virus: 2009 update by the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis 49: 659.
Department of Health and Human Services, 2009. Panel on Antiretroviral Guidelines for Adults and Adolescents: Guidelines for the Use of Antiretroviral Agents in HIV-1āInfected Adults and Adolescents. Available at: http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf. Accessed September 6, 2010.
European AIDS Clinical Society, 2010. Guidelines Clinical Management and Treatment of Chronic Hepatitis B and Hepatitis C Coinfection in HIV-Infected Adults. Available at: http://www.europeanaidsclinicalsociety.org/guidelinespdf/1_Treatment_of_HIV_Infected_Adults.pdf. Accessed September 6, 2010.
Ministry of Health Department of HIV/AIDS Prevention and Care, 2008. Botswana National HIV/AIDS Treatment Guidelines, 2008 Version. Available at: http://www.aidstarone.com/botswana_national_hivaids_treatment_guidelines_2008_version. Accessed September 6, 2010.
World Health Organization, 2008. Essential Prevention and Care Interventions for Adults and Adolescents Living with HIV in Resource-Limited Settings. Available at: http://www.who.int/hiv/pub/toolkits/Essential%20Prevention%20and%20Care%20interventioni%20Jan%2008.pdf. Accessed September 6, 2010.
Tolle MA, 2009. A package of primary health care services for comprehensive family-centred HIV/AIDS care and treatment programs in low-income settings. Trop Med Int Health 14: 663ā672.
Department of Health Republic of South Africa, 2010. The South African Antiretroviral Treatment Guidelines 2010. Available at: http://www.sanac.org.za/documents/2010%20ART%20Guideline-Short.pdf. Accessed August 10, 2010.
Firnhaber CS, Ive P, 2009. Hepatitis B and HIV co-infection in South Africa: just treat it. Southern African Journal of HIV Medicine 10: 10ā14.
World Health Organization, 2010. Antiretroviral Therapy for HIV Infection in Adults and Adolescents: Recommendations for a Public Health Approach, 2010 revision. Available at: http://whqlibdoc.who.int/publications/2010/9789241599764_eng.pdf. Accessed September 6, 2010.
Thio CL, Locarnini S, 2007. Treatment of HIV/HBV coinfection: clinical and virologic issues. AIDS Rev 9: 40ā53.
Nuesch R, Ananworanich J, Srasuebkul P, Klinbuayam W, Mahanontharit A, Jupimai T, Ruxrungtham K, Hirshcel B, 2008. Interruptions of tenofovir/emtricitabine-based antiretroviral therapy in patients with HIV/hepatitis B virus co-infection. AIDS 22: 152ā154.
Baleta A, 2010. Botswana reduces mother-to-child transmission of HIV. Lancet 375: 1954.
Read JS, Cannon MJ, Stanberry LR, Schuval S, 2008. Prevention of mother-to-child transmission of viral infections. Curr Probl Pediatr Adolesc Health Care 38: 274ā297.
Puoti M, Torti C, Bruno R, Filice G, Carosi G, 2006. Natural history of chronic hepatitis B in co-infected patients. J Hepatol 44 (Suppl 1): S65āS70.
Wang Z, Zhang J, Yang H, Li X, Wen S, Guo Y, Sun J, Hou J, 2003. Quantitative analysis of HBV DNA level and HBeAg titer in Hepatitis B surface antigen positive mothers and their babies: HBeAg passage through the placenta and the rate of decay in babies. J Med Virol 71: 360ā366.
SangarĆ© L, SombiĆ© R, CombassĆ©rĆ© AW, Kouanda A, Kania D, Zerbo O, LankoandĆ© J, 2009. Antenatal transmission of hepatitis B virus in an area of HIV moderate prevalence, Burkina Faso. Bull Soc Pathol Exot 102: 226ā229.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 25 | 25 | 4 |
Full Text Views | 737 | 326 | 1 |
PDF Downloads | 120 | 44 | 0 |
The objective of this study was to assess the prevalence of hepatitis B and hepatitis C coinfections in human immunodeficiency virus (HIV) -infected adults at an HIV center in Gaborone, Botswana. A retrospective review was performed of charts of currently active HIV-infected adult patients in the Family Model Clinic (FMC) of the Botswana-Baylor Children's Clinical Center of Excellence (BCOE) in Gaborone, Botswana, for the results of serum hepatitis B surface antigen (HBsAg) and antihepatitis C IgG tests performed between January 1, 2005 and December 15, 2009. Of 308 active FMC patients, 266 underwent HBsAg serology testing within the period of study. The HBsAg coinfection prevalence was 5.3% (14/266); 2 of 252 patients had at least one positive antihepatitis C IgG serology, a 0.8% prevalence. Hepatitis B coinfection is relatively common in HIV-infected adults at our center in Botswana, whereas hepatitis C coinfection is rare. In this setting, where the diagnosis of hepatitis B coinfection with HIV has implications for choice of first-line antiretroviral therapy and prevention of perinatal hepatitis B transmission, broader sampling to establish the true population prevalence of hepatitis B coinfection and the desirability of adding screening to HIV management should be considered. These findings provide little justification for adding hepatitis C coinfection screening to the management of HIV infection in Botswana.
Authors' addresses: Premal Patel, Michael Tolle, Vincent Mabikwa, and Gabriel Anabwani, Botswana-Baylor Children's Clinical Centre of Excellence, Gaborone, Botswana, E-mails: premal33@gmail.com, tolle@bcm.edu, vmabikwa@baylorbotswana.org.bw and ganabwani@baylorbotswana.org.bw. Stephanie Davis, Johns Hopkins School of Public Health, Baltimore, MD, E-mail: sd135626@gmail.com.
Reprint requests: Michael Tolle, Botswana-Baylor Children's Clinical Centre of Excellence, Hospital Way, Plot 1836, Gaborone, Botswana, E-mail: tolle@bcm.edu.
Modi AA, Feld JJ, 2007. Viral hepatitis and HIV in Africa. AIDS Rev 9: 25ā39.
Kiire CF, 1996. The epidemiology and prophylaxis of Hepatitis B in sub-Saharan Africa: a view from tropical and subtropical Africa. Gut 38 (Suppl 2): S5āS12.
Opaleye OO, Zakariyahu TO, Tijani BA, Bakarey AS, 2010. HBV, HCV co-infection among blood donors in Nigeria. Indian J Pathol Microbiol 53: 182ā183.
Diarra A, Kouriba B, Baby M, Murphy E, Lefrere JJ, 2009. HIV, HCV, HBV and syphilis rate of positive donations among blood donations in Mali: lower rates among volunteer blood donors. Transfus Clin Biol 16: 444ā447.
Bwogi J, Braka F, Makumbi I, Mishra V, Bakamutumaho B, Nanyunja M, Opio A, Downing R, Biryahwaho B, Lewis R, 2009. Hepatitis B infection is highly endemic in Uganda: findings from a national serosurvey. Afr Health Sci 9: 98ā108.
Tagny C, Diarra A, Yahaya R, Hakizimana M, Nguessan A, Mbensa G, NĆ©biĆ© Y, Dahourou H, Mbanya D, Shiboski C, Murphy E, LefrĆØre J, 2009. Characteristics of blood donors and donated blood in sub-Saharan Francophone Africa. Transfusion 49: 1592ā1599.
Burnett R, Francois G, Kew M, Leroux-Roels G, Meheus A, Hoosen AA, Mphahlele MJ, 2005. Hepatitis B virus and human immunodeficiency virus co-infection in sub-Saharan Africa: a call for further investigation. Liver Int 25: 201ā213.
Nacro B, Dao B, Dahourour H, 2001. HBs antigen in children with suspicion of HIV infection. J Trop Pediatr 47: 303ā304.
Combe P, La Ruche G, Bonard D, Ouassa T, Faye-Kette H, Sylla-Koko F, Dabis F, 2001. Hepatitis B and C infections, human immunodeficiency virus and other sexually transmitted infections among women of childbearing age in Cote d'Ivoire, West Africa. Trans R Soc Trop Med Hyg 95: 493ā496.
Sutcliffe S, Taha TE, Kumwenda NI, Taylor E, Liomba GN, 2002. HIV-1 prevalence and herpes simplex virus 2, hepatitis C virus, and hepatitis B virus infections among male workers at a sugar estate in Malawi. J Acquir Immune Defic Syndr 95: 493ā496.
Adewole OO, Anteyi E, Ajuwon Z, Wada I, Elegba F, Ahmed P, Betiku Y, Okpe A, Eze S, Ogbeche T, Erhabor GE, 2009. Hepatitis B and C virus co-infection in Nigerian patients with HIV infection. J Infect Dev Ctries 3: 369ā375.
Nagu TJ, Bakari M, Matee M, 2008. Hepatitis A, B and C viral co-infections among HIV-infected adults presenting for care and treatment at Muhimbili National Hospital in Dar es Salaam, Tanzania. BMC Public Health 19: 416.
Kew MC, Kassianides C, Berger EL, Song E, Dusheiko GM, 1987. Prevalence of chronic hepatitis virus infection in pregnant women living in Soweto. J Med Virol 22: 263ā268.
Vos GH, Rose EF, Marimuthu T, 1984. Hepatitis B antigen and antibodies in rural and urban southern African blacks. S Afr J Med 57: 868ā870.
Lodenyo H, Schoup B, Ally R, Kairu S, Segal I, 2000. Hepatitis B and C virus infections and liver function in AIDS patients at Chris Hani Baragwanath Hospital, Johannesburg. East Afr Med J 77: 13ā15.
Firnhaber CS, Reyneke A, Schulze D, Malope B, Maskew M, Macphail P, Sanne I, Biscerglie A, 2008. The prevalence of hepatitis B co-infection in a South African urban government HIV clinic. S Afr Med J 98: 541ā544.
Wester W, Bussmann H, Moyo S, Avalos A, Gaolathe T, Ndwapi N, Essex M, MacGregor RR, Marlink R, 2006. Serological evidence of HIV-associated infection among HIV-1āinfected adults in Botswana. Clin Infect Dis 14: 1612ā1615.
Tedla Z, Nyirenda S, Peeler C, Agizew T, Sibanda T, Motsamai O, Vernon A, Wells CD, Samandari T, 2010. Isoniazid-associated hepatitis and antiretroviral drugs during tuberculosis prophylaxis in HIV-infected adults in Botswana. Am J Respir Crit Care Med 182: 278ā285.
Byskov AJS, Wouters M, Sathekge TJ, Swanepoel R, 1989. An outbreak of suspected water-borne epidemic non-A non-B hepatitis in northern Botswana with a high prevalence of hepatitis B carriers and hepatitis delta markers among patients. Trans R Soc Trop Med Hyg 83: 110ā116.
Mulwa JKM, 1994. Hepatitis B situation in Botswana. J Prev Med Hyg 35: 67.
Nurse GT, Tanaka N, MacNab G, Jenkins T, 1973. Non-venereal syphilis and Australia antigen among the G/Wi and G-Ana San of the Central Kalahari Reserve, Botswana. Cent Afr J Med 19: 10.
Dibisceglie AM, Kew MC, Dusheiko GM, Berger EL, Song E, Paterson AC, Hodkinson HJ, 1986. Prevalence of hepatitis B virus infection among black children in Soweto. Br Med J (Clin Res Ed) 292: 1440ā1442.
Madhava V, Burgess C, Drucker E, 2002. Epidemiology of chronic hepatitis C virus infection in sub-Saharan Africa. Lancet Infect Dis 2: 293ā302.
Kallestrup P, Zinyama R, Gomo E, 2003. Low prevalence of HCV antibodies in HIV-endemic area of Zimbabwe support sexual transmission as the major route of HIV transmission in Africa. AIDS 17: 1400ā1402.
Patel P, Davis S, Tolle M, Anabwani G, 2010. The Family Medical Clinic (FMC) at the Botswana-Baylor Children's Clinical Centre of Excellence (BBCCCOE) in Gaborone, BotswanaāA model of care. Proceedings of the 19th International AIDS Conference, July 18ā23, 2010; Vienna, Austria.
Aberg J, Kaplan J, Libman H, Emmanuel P, Anderson J, Stone V, Oleske J, Currier J, Gallant J, 2009. IDSA guidelines: primary care guidelines for the management of persons infected with human immunodeficiency virus: 2009 update by the HIV Medicine Association of the Infectious Diseases Society of America. Clin Infect Dis 49: 659.
Department of Health and Human Services, 2009. Panel on Antiretroviral Guidelines for Adults and Adolescents: Guidelines for the Use of Antiretroviral Agents in HIV-1āInfected Adults and Adolescents. Available at: http://www.aidsinfo.nih.gov/ContentFiles/AdultandAdolescentGL.pdf. Accessed September 6, 2010.
European AIDS Clinical Society, 2010. Guidelines Clinical Management and Treatment of Chronic Hepatitis B and Hepatitis C Coinfection in HIV-Infected Adults. Available at: http://www.europeanaidsclinicalsociety.org/guidelinespdf/1_Treatment_of_HIV_Infected_Adults.pdf. Accessed September 6, 2010.
Ministry of Health Department of HIV/AIDS Prevention and Care, 2008. Botswana National HIV/AIDS Treatment Guidelines, 2008 Version. Available at: http://www.aidstarone.com/botswana_national_hivaids_treatment_guidelines_2008_version. Accessed September 6, 2010.
World Health Organization, 2008. Essential Prevention and Care Interventions for Adults and Adolescents Living with HIV in Resource-Limited Settings. Available at: http://www.who.int/hiv/pub/toolkits/Essential%20Prevention%20and%20Care%20interventioni%20Jan%2008.pdf. Accessed September 6, 2010.
Tolle MA, 2009. A package of primary health care services for comprehensive family-centred HIV/AIDS care and treatment programs in low-income settings. Trop Med Int Health 14: 663ā672.
Department of Health Republic of South Africa, 2010. The South African Antiretroviral Treatment Guidelines 2010. Available at: http://www.sanac.org.za/documents/2010%20ART%20Guideline-Short.pdf. Accessed August 10, 2010.
Firnhaber CS, Ive P, 2009. Hepatitis B and HIV co-infection in South Africa: just treat it. Southern African Journal of HIV Medicine 10: 10ā14.
World Health Organization, 2010. Antiretroviral Therapy for HIV Infection in Adults and Adolescents: Recommendations for a Public Health Approach, 2010 revision. Available at: http://whqlibdoc.who.int/publications/2010/9789241599764_eng.pdf. Accessed September 6, 2010.
Thio CL, Locarnini S, 2007. Treatment of HIV/HBV coinfection: clinical and virologic issues. AIDS Rev 9: 40ā53.
Nuesch R, Ananworanich J, Srasuebkul P, Klinbuayam W, Mahanontharit A, Jupimai T, Ruxrungtham K, Hirshcel B, 2008. Interruptions of tenofovir/emtricitabine-based antiretroviral therapy in patients with HIV/hepatitis B virus co-infection. AIDS 22: 152ā154.
Baleta A, 2010. Botswana reduces mother-to-child transmission of HIV. Lancet 375: 1954.
Read JS, Cannon MJ, Stanberry LR, Schuval S, 2008. Prevention of mother-to-child transmission of viral infections. Curr Probl Pediatr Adolesc Health Care 38: 274ā297.
Puoti M, Torti C, Bruno R, Filice G, Carosi G, 2006. Natural history of chronic hepatitis B in co-infected patients. J Hepatol 44 (Suppl 1): S65āS70.
Wang Z, Zhang J, Yang H, Li X, Wen S, Guo Y, Sun J, Hou J, 2003. Quantitative analysis of HBV DNA level and HBeAg titer in Hepatitis B surface antigen positive mothers and their babies: HBeAg passage through the placenta and the rate of decay in babies. J Med Virol 71: 360ā366.
SangarĆ© L, SombiĆ© R, CombassĆ©rĆ© AW, Kouanda A, Kania D, Zerbo O, LankoandĆ© J, 2009. Antenatal transmission of hepatitis B virus in an area of HIV moderate prevalence, Burkina Faso. Bull Soc Pathol Exot 102: 226ā229.
Past two years | Past Year | Past 30 Days | |
---|---|---|---|
Abstract Views | 25 | 25 | 4 |
Full Text Views | 737 | 326 | 1 |
PDF Downloads | 120 | 44 | 0 |