Ivermectin Mass Drug Administration to Humans Disrupts Malaria Parasite Transmission in Senegalese Villages

Kevin C. Kobylinski Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Department of Statistics, Colorado State University, Fort Collins, Colorado; Ministère de la Santé et de la Prévention Médicale, Dakar, Senegal

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Massamba Sylla Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Department of Statistics, Colorado State University, Fort Collins, Colorado; Ministère de la Santé et de la Prévention Médicale, Dakar, Senegal

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Phillip L. Chapman Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Department of Statistics, Colorado State University, Fort Collins, Colorado; Ministère de la Santé et de la Prévention Médicale, Dakar, Senegal

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Moussa D. Sarr Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Department of Statistics, Colorado State University, Fort Collins, Colorado; Ministère de la Santé et de la Prévention Médicale, Dakar, Senegal

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Brian D. Foy Arthropod-borne and Infectious Diseases Laboratory, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, Colorado; Department of Statistics, Colorado State University, Fort Collins, Colorado; Ministère de la Santé et de la Prévention Médicale, Dakar, Senegal

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Ivermectin mass drug administration (MDA) to humans is used to control onchocerciasis and lymphatic filariasis. Recent field studies have shown an added killing effect of ivermectin MDA against malaria vectors. We report that ivermectin MDA reduced the proportion of Plasmodium falciparum infectious Anopheles gambiae sensu stricto (s.s.) in treated villages in southeastern Senegal. Ivermectin MDA is a different delivery method and has a different mode of action from current malaria control agents. It could be a powerful and synergistic new tool to reduce malaria transmission in regions with epidemic or seasonal malaria transmission, and the prevalence and intensity of neglected tropical diseases.

Author Notes

*Address correspondence to Kevin C. Kobylinski, Massamba Sylla, and Brian D. Foy, Department of Microbiology, Immunology and Pathology, 1692 Campus delivery, Fort Collins, CO 80523-1692. E-mails: kobylinskikevin@yahoo.com, massamba.sylla@colostate.edu, and brian.foy@colostate.edu
†These authors contributed equally to this work.

Financial support: This work was supported by the NIH grant R21 AI079528, Grand Challenges Explorations grant 51995 from the Bill and Melinda Gates Foundation, and CRC grant 1686174 from Colorado State University.

Authors' addresses: Kevin C. Kobylinski, Massamba Sylla, and Brian D. Foy, Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, E-mails: kobylinskikevin@yahoo.com, massamba.sylla@colostate.edu, and brian.foy@colostate.edu. Phillip L. Chapman, Department of Statistics, Fort Collins, CO, E-mail: pchapman@stat.colostate.edu. Moussa D. Sarr, Ministère de la Santé et de la Prévention Médicale, Dakar, Senegal, E-mail: mdiensarr@yahoo.fr.

Reprint requests: Brian D. Foy Department of Microbiology, Immunology and Pathology, 1692 Campus delivery, Fort Collins, CO 80523-1692, E-mail: brian.foy@colostate.edu.

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