Incidence of Bacteremic Melioidosis in Eastern and Northeastern Thailand

Saithip Bhengsri International Emerging Infections Program (IEIP), Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Nakhon Phanom Hospital, Thailand Ministry of Public Health, Nakhon Phanom Province, Thailand; Crown Prince Hospital, Thailand Ministry of Public Health, Sa Kaeo, Thailand; National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand

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Henry C. Baggett International Emerging Infections Program (IEIP), Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Nakhon Phanom Hospital, Thailand Ministry of Public Health, Nakhon Phanom Province, Thailand; Crown Prince Hospital, Thailand Ministry of Public Health, Sa Kaeo, Thailand; National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand

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Possawat Jorakate International Emerging Infections Program (IEIP), Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Nakhon Phanom Hospital, Thailand Ministry of Public Health, Nakhon Phanom Province, Thailand; Crown Prince Hospital, Thailand Ministry of Public Health, Sa Kaeo, Thailand; National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand

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Anek Kaewpan International Emerging Infections Program (IEIP), Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Nakhon Phanom Hospital, Thailand Ministry of Public Health, Nakhon Phanom Province, Thailand; Crown Prince Hospital, Thailand Ministry of Public Health, Sa Kaeo, Thailand; National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand

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Prabda Prapasiri International Emerging Infections Program (IEIP), Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Nakhon Phanom Hospital, Thailand Ministry of Public Health, Nakhon Phanom Province, Thailand; Crown Prince Hospital, Thailand Ministry of Public Health, Sa Kaeo, Thailand; National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand

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Sathapana Naorat International Emerging Infections Program (IEIP), Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Nakhon Phanom Hospital, Thailand Ministry of Public Health, Nakhon Phanom Province, Thailand; Crown Prince Hospital, Thailand Ministry of Public Health, Sa Kaeo, Thailand; National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand

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Somsak Thamthitiwat International Emerging Infections Program (IEIP), Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Nakhon Phanom Hospital, Thailand Ministry of Public Health, Nakhon Phanom Province, Thailand; Crown Prince Hospital, Thailand Ministry of Public Health, Sa Kaeo, Thailand; National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand

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Kittisak Tanwisaid International Emerging Infections Program (IEIP), Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Nakhon Phanom Hospital, Thailand Ministry of Public Health, Nakhon Phanom Province, Thailand; Crown Prince Hospital, Thailand Ministry of Public Health, Sa Kaeo, Thailand; National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand

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Somrak Chantra International Emerging Infections Program (IEIP), Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Nakhon Phanom Hospital, Thailand Ministry of Public Health, Nakhon Phanom Province, Thailand; Crown Prince Hospital, Thailand Ministry of Public Health, Sa Kaeo, Thailand; National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand

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Prasert Salika International Emerging Infections Program (IEIP), Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Nakhon Phanom Hospital, Thailand Ministry of Public Health, Nakhon Phanom Province, Thailand; Crown Prince Hospital, Thailand Ministry of Public Health, Sa Kaeo, Thailand; National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand

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Surang Dejsirilert International Emerging Infections Program (IEIP), Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Nakhon Phanom Hospital, Thailand Ministry of Public Health, Nakhon Phanom Province, Thailand; Crown Prince Hospital, Thailand Ministry of Public Health, Sa Kaeo, Thailand; National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand

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Leonard F. Peruski International Emerging Infections Program (IEIP), Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Nakhon Phanom Hospital, Thailand Ministry of Public Health, Nakhon Phanom Province, Thailand; Crown Prince Hospital, Thailand Ministry of Public Health, Sa Kaeo, Thailand; National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand

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Susan A. Maloney International Emerging Infections Program (IEIP), Thailand Ministry of Public Health – U.S. Centers for Disease Control and Prevention Collaboration, Nonthaburi, Thailand; Nakhon Phanom Hospital, Thailand Ministry of Public Health, Nakhon Phanom Province, Thailand; Crown Prince Hospital, Thailand Ministry of Public Health, Sa Kaeo, Thailand; National Institute of Health, Thailand Ministry of Public Health, Nonthaburi, Thailand

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DOI:
https://doi.org/10.4269/ajtmh.2011.11-0070
Volume/Issue:
Volume 85: Issue 1
Page(s):
117–120
Restricted access
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Burkholderia pseudomallei, the causative agent of melioidosis, is endemic in northeastern Thailand. Population-based disease burden estimates are lacking and limited data on melioidosis exist from other regions of the country. Using active, population-based surveillance, we measured the incidence of bacteremic melioidosis in the provinces of Sa Kaeo (eastern Thailand) and Nakhon Phanom (northeastern Thailand) during 2006–2008. The average annual incidence in Sa Kaeo and Nakhon Phanom per 100,000 persons was 4.9 (95% confidence interval [CI] = 3.9–6.1) and 14.9 (95% CI = 13.3–16.6). The respective population mortality rates were 1.9 (95% CI = 1.3–2.8) and 4.4 (95% CI = 3.6–5.3) per 100,000. The case-fatality proportion was 36% among those with known outcome. Our findings document a high incidence and case fatality proportion of bacteremic melioidosis in Thailand, including a region not traditionally considered highly endemic, and have potential implications for clinical management and health policy.

Author Notes

*Address correspondence to Saithip Bhengsri, International Emerging Infections Program (IEIP), Thailand Ministry of Public Health (MOPH) – U.S. Centers for Disease Control and Prevention Collaboration, 3rd Floor, Building 7, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand, 11000. E-mail: saithipb@th.cdc.gov

Disclosure: These data were presented as an oral presentation at the 57th American Society of Tropical Medicine and Hygiene Annual Meeting, New Orleans, LA. Scientific Session No. 75, Bacteriology III, Presentation No. 418.

Authors' addresses: Saithip Bhengsri, Henry C. Baggett, Possawat Jorakate, Anek Kaewpan, Prabda Prapasiri, Sathapana Naorat, Somsak Thamthitiwat, Prasert Salika, Leonard F. Peruski, and Susan A. Maloney, International Emerging Infections Program, Thailand MOPH-US CDC Collaboration, Department of Disease Control, Ministry of Public Health, Nonthaburi, Thailand, E-mails: SaithipB@th.cdc.gov, KipB@th.cdc.gov, PossawatJ@th.cdc.gov, AnekK@th.cdc.gov, PrabdaP@th.cdc.gov, SathapanaN@th.cdc.gov, SomsakT@th.cdc.gov, PrasertS@th.cdc.gov, LeonardP@th.cdc.gov, and SusanM@th.cdc.gov. Kittisak Tanwisaid, Nakhon Phanom Hospital, Nakhon Phanom, Thailand, E-mail: Kittisak97@gmail.com. Somrak Chantra, Sa Kaeo Crown Prince Hospital, Sa Kaeo, Thailand, E-mail: SomrakC@hotmail.com. Surang Dejsirilert, National Institute of Health, Department of Medical Science, Ministry of Public Health, Nonthaburi, Thailand, E-mail: Surang_dej@yahoo.com.

Copyright:
©The American Society of Tropical Medicine and Hygiene 2011
Received:
02 Feb 2011
|
Accepted:
02 Apr 2011
|
Published Online:
01 Jul 2011
Cover The American Journal of Tropical Medicine and Hygiene
The American Journal of Tropical Medicine and Hygiene
Print ISSN:
0002-9637
Online ISSN:
1476-1645
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