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| Past two years | Past Year | Past 30 Days | |
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| Abstract Views | 1618 | 1440 | 620 |
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Challenges in Recognition and Diagnosis of Yaws in Children in Papua New Guinea
Oriol Mitjà
Oriol Mitjà
Department of Medicine, and Department of Microbiology, Lihir Medical Centre, International SOS, Lihir Island, Papua New Guinea; Barcelona Centre for International Health Research, Hospital Clínic, University of Barcelona, Barcelona, Spain
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Russell Hays
Russell Hays
Department of Medicine, and Department of Microbiology, Lihir Medical Centre, International SOS, Lihir Island, Papua New Guinea; Barcelona Centre for International Health Research, Hospital Clínic, University of Barcelona, Barcelona, Spain
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Francis Lelngei
Francis Lelngei
Department of Medicine, and Department of Microbiology, Lihir Medical Centre, International SOS, Lihir Island, Papua New Guinea; Barcelona Centre for International Health Research, Hospital Clínic, University of Barcelona, Barcelona, Spain
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Nedley Laban
Nedley Laban
Department of Medicine, and Department of Microbiology, Lihir Medical Centre, International SOS, Lihir Island, Papua New Guinea; Barcelona Centre for International Health Research, Hospital Clínic, University of Barcelona, Barcelona, Spain
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Anthony Ipai
Anthony Ipai
Department of Medicine, and Department of Microbiology, Lihir Medical Centre, International SOS, Lihir Island, Papua New Guinea; Barcelona Centre for International Health Research, Hospital Clínic, University of Barcelona, Barcelona, Spain
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Slim Pakarui
Slim Pakarui
Department of Medicine, and Department of Microbiology, Lihir Medical Centre, International SOS, Lihir Island, Papua New Guinea; Barcelona Centre for International Health Research, Hospital Clínic, University of Barcelona, Barcelona, Spain
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Quique Bassat
Quique Bassat
Department of Medicine, and Department of Microbiology, Lihir Medical Centre, International SOS, Lihir Island, Papua New Guinea; Barcelona Centre for International Health Research, Hospital Clínic, University of Barcelona, Barcelona, Spain
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A global resurgence of yaws in developing countries highlights the need for reliable diagnostic criteria for this neglected infection. We conducted a clinical and serologic survey of 233 children less than 15 years of age who had clinically suspected yaws. A total of 138 (59%) cases were confirmed serologically, and 10 of 12 primary stage cases showed positive results for Treponema pallidum by a polymerase chain reaction assay that has not yet been validated for identification of yaws. A high proportion of cases (46%) were in the secondary stage; 92% of them had osteoarticular involvement, and only 24% had a Venereal Disease Research Laboratory titer greater than 1:32.
Author Notes
Financial support: This study was supported by the International SOS (Australasia) Pty. Ltd. and Newcrest Mining.
Disclosure: None of the authors has any conflicts of interest.
Authors' addresses: Oriol Mitjà, Russell Hays, Francis Lelngei, Nedley Laban, Anthony Ipai, and Slim Pakarui, Department of Medicine, Lihir Medical Centre, Lihir Island, New Ireland Province, Papua New Guinea, E-mails: oriolmitja@hotmail.com, rhays@ozemail.com.au, francis.lelngei@newcrest.au.com, nedley.laban@newcrest.au.com, anthony.ipai@newcrest.au.com, and slim.pakarui@newcrest.au.com. Quique Bassat, Barcelona Centre for International Health Research, Hospital Clinic, Barcelona, Spain, E-mail: quique.bassat@cresib.cat.
ProCite
RefWorks
Reference Manager
BibTeX
Zotero
EndNote
-
1.
Engelkens HJ, Vuzevski VD, Stolz E, 1999. Nonvenereal treponematoses in tropical countries. Clin Dermatol 17: 143–152.
-
2.
Meheus A, 2005. Non-venereal treponematoses. Medicine 33: 82–84.
-
3.
Asiedu K, Amouzou B, Dhariwal A, Karam M, Lobo D, Patnaik S, 2008. Yaws eradication: past efforts and future perspectives. Bull World Health Organ 86: 499–499A.
-
4.
Rinaldi A, 2008. Yaws: a second (and maybe last?) chance for eradication. PLoS Negl Trop Dis 2: e275.
-
5.
Perine PL, Hopkins DR, Niemel PLA, Feeley JC, 1984. Handbook of Endemic Treponematoses. Geneva: World Health Organization.
-
6.
Gerstl S, Kiwila G, Dhorda M, Lonlas S, Myatt M, Ilunga BK, Lemasson D, Szumilin E, Guerin PJ, Ferradini L, 2009. Prevalence study of yaws in the Democratic Republic of Congo using the lot quality assurance sampling method. PLoS ONE 4: e6338.
-
7.
Fegan D, Glennon MJ, Thami Y, Pakoa G, 2010. Resurgence of yaws in Tanna, Vanuatu: time for a new approach? Trop Doct 40: 68–69.
-
8.
Manning LA, Ogle GD, 2002. Yaws in the periurban settlements of Port Moresby, Papua New Guinea. P N G Med J 45: 206–212.
-
9.
Reid MS, 1985. Yaws in Papua New Guinea: extent of the problem and status of control programs. Rev Infect Dis 7: 254–259.
-
10.
Engelkens HJH, Vuzevski VD, Judanarso J, van Lier JBH, van der Stek J, van der Sluis JJ, Stolz E, 1990. Early yaws: a light microscopic study. Genitourin Med 66: 264–266.
-
11.
Landersdorfer CB, Bulitta JB, Kinzig M, Holzgrabe U, Sörgel F, 2009. Penetration of antibacterials into bone: pharmacokinetic, pharmacodynamic and bioanalytical considerations. Clin Pharmacokinet 48: 89–124.
-
12.
Singh AE, Romanowski B, 1999. Syphilis: review with emphasis on clinical, epidemiologic, and some biologic features. Clin Microbiol Rev 12: 187–209.
-
13.
McMillan A, Young H, 2008. Qualitative and quantitative aspects of the serological diagnosis of early syphilis. Int J STD AIDS 19: 620–624.
-
14.
Palmer H, Higgins S, Herring A, Kingston M, 2003. Use of PCR in the diagnosis of early syphilis in the United Kingdom. Sex Transm Infect 79: 479–483.
-
15.
Heymans R, van der Helm JJ, de Vries H, Fennema HS, Coutinho RA, Bruisten SM, 2010. Clinical value of Treponema pallidum real-time PCR for diagnosis of syphilis. J Clin Microbiol 48: 497–502.
| Past two years | Past Year | Past 30 Days | |
|---|---|---|---|
| Abstract Views | 1618 | 1440 | 620 |
| Full Text Views | 391 | 8 | 0 |
| PDF Downloads | 117 | 9 | 0 |