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Therapeutic Efficacy and Effects of Artemether-Lumefantrine and Artesunate-Amodiaquine Coformulated or Copackaged on Malaria-Associated Anemia in Children with Uncomplicated Plasmodium falciparum Malaria in Southwest Nigeria

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  • Department of Pharmacology and Therapeutics, Institute for Medical Research Training, and Department of Physiology, University of Ibadan, Ibadan, Nigeria
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The therapeutic efficacy and effects of artemether-lumefantrine (AL) and artesunate-amodiaquine co-formulated (AAcf) or co-packaged (AAcp) on malaria-associated anemia (MAA) were evaluated in 285 children < 12 years of age with uncomplicated Plasmodium falciparum malaria randomized to receive one of the three drug combinations. Fever and parasite clearance times were similar in all treatment groups. Mean drug-attributable fall in hematocrit (DAFH), defined as difference between hematocrit values pre- and 3 d post- initiation of treatment, was low (< 4.5%) and rates of recovery from MAA were similar with all treatments. Mean areas under curve (AUCs) of the plot of deficit in hematocrit levels from 30% versus time in anemic children were similar in all groups. All regimens were well tolerated. AL, AAcf and AAcp cleared fever and parasitemia rapidly and had similar rates of resolution of MAA after treatment in malarious Nigerian children.

Author Notes

*Address correspondence to Akintunde Sowunmi, Department of Clinical Pharmacology, University College Hospital, Ibadan, Oyo State, 23401, Nigeria. E-mail: akinsowunmi@hotmail.com

Authors' addresses: Grace O. Gbotosho, Akintunde Sowunmi, Titilope M. Okuboyejo, Christian T. Happi, Onikepe A. Folarin, and Obaro S. Michael, Department of Pharmacology and Therapeutics and Institute for Medical Research and Training, University of Ibadan, Ibadan, Nigeria, E-mails: solagbotosho@yahoo.co.uk, akinsowunmi@hotmail.com, attitte@yahoo.com, christianhappi@hotmail.com, onikepefolarin@yahoo.com, and micobaro@yahoo.com. Elsie O. Adewoye, Department of Physiology, University of Ibadan, Ibadan, Nigeria, E-mail: elolade@yahoo.com.

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