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Serologic Imprint of Dengue Virus in Urban Haiti: Characterization of Humoral Immunity to Dengue in Infants and Young Children

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  • Department of Pediatrics, and Department of Biostatistics, Vanderbilt University, Nashville, Tennessee; Les Centres GHESKIO, Port-au-Prince, Haiti; Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland; Division of Infectious Diseases and International Medicine, Weill Medical College of Cornell, New York, New York; Division of Infectious Disease and International Health, Dartmouth Medical School, Hanover, New Hampshire

Dengue is endemic to Haiti but not recognized as an important illness in the autochthonous population. To evaluate the prevalence of antibodies to dengue virus (DENV), serum samples from infants and young children 7–36 months of age (n = 166) were assayed by plaque reduction neutralization assays to each DENV serotype. Dengue virus serotype 1 had infected 40% of this study population, followed by serotype 2 (12%), serotype 3 (11%), and serotype 4 (2%). Fifty-three percent of infants and young children less than 12 months of age had already experienced DENV infection, and the seroprevalence of antibody to DENV increased to 65% by 36 months. Heterotypic antibody responses were an important component of the total dengue immunity profile.

Author Notes

*Address correspondence to Meghan Rioth, Vanderbilt University, 2200 Children's Way, Nashville, TN 37232. E-mail: meghan.rioth@vanderbilt.edu

Financial support: The study was supported by an Infectious Disease Society of America summer fellowship to Meghan Rioth, a supplement to the Caribbean, Central, and South America network for HIV epidemiology (CCASAnet), and the Vanderbilt Emphasis Program.

Authors' addresses: Meghan Rioth, Vanderbilt University, Nashville, TN, E-mail: meghan.rioth@vanderbilt.edu. Carole Anne Beauharnais, Francine Noel, and Jean W. Pape, GHESKIO Centers, Port-au-Prince, E-mails: caroleanne26@hotmail.com, fsevere@gheskio.org, and jwpape@gheskio.org. Mine R. Ikizler, Pediatric Infectious Diseases, Nashville, TN, E-mail: mine.ikizler@vanderbilt.edu. Sapna Mehta, E-mail: mehta_sapna@hotmail.com. Yuwei Zhu, Department of Biostatistics, Vanderbilt University, Nashville, TN, E-mail: yuwei.zhu@vanderbilt.edu. Carole A. Long, Malaria Immunology Section, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD, E-mail: clong@niaid.nih.gov. Peter F. Wright, Dartmouth Medical School, Lebanon, NH, E-mail: peter.f.wright@dartmouth.edu.

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