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Humoral Immune Response against P2β from Trypanosoma cruzi in Persons with Chronic Chagas Disease: Its Relationship with Treatment Against Parasites and Myocardial Damage

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  • Centro de Investigaciones Sobre Endemias Nacionales, Laboratorio de Tecnología Inmunológica, Facultad de Bioquímica y Ciencias Biológicas, Universidad Nacional del Litoral, Santa Fe, Argentina; Instituto de Inmunología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Rosario, Argentina

We investigated the relationship between potentially pathogenic antibodies against a Trypanosoma cruzi ribosomal protein (P2β) and the evolution of Chagas disease and the effect of trypanocidal treatment on these variables. Seventy-eight patients with chronic Chagas disease who were followed-up for more than 20 years were divided into three groups: 30 asymptomatic persons undergoing specific treatment (group A), 37 asymptomatic persons not undergoing specific treatment (group B), and 11 patients with chronic chagasic cardiomyopathy (CCC) who were not treated. Five patients in group B showed evolution to myocardial abnormalities. Among persons with CCC, six showed no changes; the remaining persons showed progression of cardiac involvement. Levels of antibodies to P2β in persons in group A decreased from their initial values. This finding was not observed in persons in groups B and C. Comparisons at the end of the follow-up showed lower amounts of antibodies to P2β in groups A and C. These findings support the benefits of specific treatment during chronic infection.

Author Notes

*Address correspondence to Diana L. Fabbro, 25 de Mayo 1524, 3000 Santa Fe, Argentina. E-mail: dfabbro@fbcb.unl.edu.ar

Financial support: The study was supported by the Secretariat for Science and Technology of the Littoral National University.

Authors' addresses: Diana L. Fabbro, Verónica Olivera, Maria Laura Bizai, Susana Denner, Mirtha Streiger, Enrique Arias, Mónica Del Barco, and Diego Mendicino, Facultad de Bioquímica y Ciencias Biológicas, Centro de Investigaciones Sobre Endemias Nacionales, Universidad Nacional del Litoral, Ciudad Universitaria Paraje el Pozo 3000, Santa Fe, Argentina, E-mail: dfabbro@fbcb.unl.edu.ar. Cristina Diez and Iván Mancipar, Facultad de Bioquímica y Ciencias Biológicas, Laboratorio de Tecnología Inmunológica, Universidad Nacional del Litoral, Ciudad Universitaria Paraje el Pozo 3000, Santa Fe, Argentina. Oscar Bottasso, Facultad de Ciencias Médicas, Instituto de Inmunología, Universidad Nacional de Rosario, Santa Fe 3100 2000, Rosario, Argentina.

Reprint requests: Diana L. Fabbro, 25 de Mayo 1524, 3000 Santa Fe, Argentina.

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