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Systemic Meglumine Antimoniate in Acute Cutaneous Leishmaniasis: Children versus Adults

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  • Research Center for Skin Diseases and Cutaneous Leishmaniasis, Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran; Mashhad University of Medical Sciences, Mashhad, Iran

Some studies showed that children have a lower response to systemic use of pentavalent antimoniate than adults. We aimed to evaluate the response rate to Glucantime therapy in children and compare it with adults. One hundred and twelve patients with acute cutaneous leishmaniais (ACL) were divided into two equal groups of adults (> 15 yrs) and children (≤ 15 yrs). They received meglumine antimoniate; 20 mg/kg/day for 20 days, their improvement rate was evaluated 20 and 45 days after treatment. Perprotocol analysis showed a significantly lower response in the children group 20 and 45 days after initiation of the treatment (P = 0.0001, 95% confidence interval [CI] = 0.190 [0.079–0.456]/P = 0.0051, 95% CI = 0.317 [0.140–0.717], respectively). Moreover, after intention-to-treat analysis, the same results were seen in the younger group 20 and 45 days after treatment (P = 0.0003, 95% CI = 0.228 [0.098–0.528]/P = 0.0132, 95% CI = 0.382 [0.177–0.825], respectively). According to our results, systemic Glucantime has lower efficacy in treating ACL in children than adults.

Author Notes

*Address correspondence to Pouran Layegh, Research Center for Skin Diseases and Cutaneous Leishmaniasis, Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran. E-mails: Layeghpo@mums.ac.ir or Pouran_layegh@yahoo.com

Authors' addresses: Pouran Layegh, Research Center for Skin Diseases and Cutaneous Leishmaniasis, Qaem Hospital, Mashhad University of Medical Sciences, Mashhad, Iran, E-mails: Layeghpo@mums.ac.ir or Pouran_layegh@yahoo.com. Sara Rahsepar, Research Center for Skin Diseases and Cutaneous Leishmaniasis, Qaem Hospital, Mashhad University of Medical Science, Mashhad, Iran, E-mail: rahsepars891@mums.ac.ir. Amir Ali Rahsepar, Qaem Hospital, Mashhad University of Medical Science, Mashhad, Iran, E-mail: rahseparaa841@mums.ac.ir.

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